Squick: When celebrating their entry into the World Records, the fat residents of Springfield shake their guts, with appropriate sounds and jiggling.
Lenny's toothless smile he gives to the camera at the end of the episode
Homer licking blood and vapor rub off the Kwick-E-Mart floor.
Tear Jerker: The death of Ron Taylor, voice of Bleeding Gums Murphy, who this episode was dedicated to.
Unintentionally Unsympathetic: Marge for insisting Homer dump the sugar cargo, even if by that point it was absolutely clear that the ban did far more harm than good. Homer could also qualify for doing as she wanted.