Funny Moments: The "panel innocently asking questions" format, combined with contestants like "A. Harem" (August 4, 1953), typically meant Hilarity Ensues. Game Show Moments Gone Bananas showed clips of "A. Mattress" (October 1, 1952) and "A. Maid" (March 17, 1953), which went pretty much in the same direction.
Moment of Awesome: Any contestant who stumped the (especially four-member) panel through the latter running out of questions. Overlapped with Funny Moments on occasion, when the panel went into desperation mode and started asking off-the-wall questions when their "stock" began getting low. Inversely, panelists who got the right answer through said off-the-wall questions.
Replacement Scrappy: The hosts of Season 4, having to follow Lewis. Bob & Ray are generally singled out, partly since they were between longtime TV stalwart James and the very capable Fadiman.
They Changed It, Now It Sucks: The "Celebrity Relatives" segment, which didn't really fit the show's premise. (It was eventually tossed out after six months, though.)