Alternative Character Interpretation: Was Totenkopf the actual mastermind of his ultimate plan? Did his machines turn against him before he died? Did they murder him? Was he sane to begin? Considering how little is shown about him and his plan, those questions have no answer.
Big-Lipped Alligator Moment: The miniaturized elephant in the kidnapped scientist's laboratory is never brought up afterwards, as despite the clonation stuff in his island, Totenkopf is never implied to be interested in mini-size lifeforms, and the purpose of that experiment remains unexplained.