Promethean a very niche appeal at best, with its premise of "you're an Artificial Human whom all of reality rejects, so your only goal in life is to Become a Real Boy" and punishing rules in support of it.
Second Edition softens these rules a bit, or rather it gives options to keep them from driving every player to hack at her wrists with a sharp spork.
Complete Monster: Most evil Prometheans are motivated by years of torment they have received at the hands of regular mortals. Not so Oleg Wormwood, Ukrainian mobster, Zeka (Russian for "prisoner"), and would-be bringer of the Apocalypse. Created at the time of the Chernobyl disaster, Oleg witnessed the meltdown, and, despite having a relatively good life by Promethean standards, desired to replicate it across the face of the world. Joining the Ukrainian, and then Russian branches of The Mafiya, Oleg killed numerous men (and gave large numbers of prostitutes cancer) in the process of making a name for himself, all while building up the connections and resources he would need to achieve his dream. He has purchased plutonium for terrorist causes, stirred up trouble between India and Pakistan, and otherwise done everything he can to manipulate the world's leaders into creating the nuclear holocaust that he so desperately craves. Emotionally hollow, and incapable of remorse, Oleg has no desire to ever be human, viewing mortals as nothing but tools to aid him in triggering The End of the World as We Know It.
Crowning Moment of Awesome: In the second edition framing fiction for the Tammuz, a mine boss describes how Clay, a Tammuz working for him without his understanding of Clay's supernatural nature, rescued the entire shift he was with when all the generators went down and the air pumps stopped working. He did this by climbing the elevator cable with his bare hands and with one of his shift-mates slung over his shoulders. Not just once, but repeatedly, going back and forth with one passenger at a time, until he'd lifted every last one of them to safety.
I Am Not Shazam: Frankenstein is the name of the Linage's demiurge, not the monster he created. Said monster prefers if you call him Mr. Verney, please.
Paranoia Fuel: Pandorans in Dormancy often resemble the sorts of inanimate things that you might mistake for monsters out of the corner of your eye.
The backstory for the sample Torch-Born. Even if you do everything right, and with the best of intentions, you can still end up creating a monster. Knowing how it's going to turn out doesn't make reading about the unfortunate Frankenstein's plans to raise his son any easier.
Pandorans can reach Woobie, Destroyer of Worlds status. One sample Pandoran, after feasting on a Promethean, gained a brief moment of lucid sentience, and realized that while Prometheans have a chance to become human and be freed of their curse, Pandorans do not have that option. It then wept the fact that they are cursed with the Horror Hunger as monsters, forever.
Almost the entire Promethean race could qualify; they seek humanity, but never quite fit in with it, feeling out of sync with it at best and inspiring fear and hatred with their very presence at the worst. They suffer and learn, all for the reward of a soul, but even that may not guarantee them happiness in the end.
Special mention: An Galateid attained her humanity and was reborn while retaining her memories as a Promethean; her husband, whom she had met on the first day of her human life, dies in front of her eyes and she then uses her knowledge of the Prometheans to rebirth him. Albeit he now exists without the memories of their love, the text indicates she's starting to act like a Stalker with a Crush and that he's not likely to regain his humanity any time soon.