These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Lowest Common Denominator: The comic seems to have a very specific target audience: People who play poker. If you don't really play the game that much, you probably won't get any of the jokes. Except for the toilet humor.