- Holy Shit Quotient: The final boss. Especially when he explodes into a skull on an extending spine.
- JonTron: I've never seen a game go from a perfect 0 to a perfect 10 so quickly.
- Nightmare Fuel: The final fight against Mr. Big's giant noggin. And then his giant skull. Then some giant roaches that come out his giant skull. For such an aggressively anti-drug plot, this boss fight seems to have been the direct result of someone ingesting many, many different types of mood-altering substances. Which is why its "anti-drug" message has a very tongue-in-cheek flavor.
- What Do You Mean, It Wasn't Made on Drugs?: Irony of ironies...Between the giant skull final boss, a pornographer clown, and the sheer audacity of solving drug crimes with rocket launchers (and the glittering shrapnel from blown-up enemies), it's safe to say that this trope is in effect.