These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
"Take Your Keiki to Work Day" has Marie ramble on at one point about how Geena Davis once visited her restaurant, and then express joy at the sight of Davis finding work again. Peter even acknowledges in a text box on the bottom of the screen that the gig Marie referred to, Commander In Chief, didn't revitalize Geena Davis' career as well as initially hoped (she won an Emmy for the role, whereupon ABC promptly stuck it to the show).
"The Angry Beefer" ends with a Flash Forward revealing that eventually, Blip TV went offline. Consequently, all the videos at TGWTPRH disappeared, except for the few that the website's fans downloaded and re-uploaded. After Blip's May 2014 announcement that a purchase by Maker Studios will result in some That Guy with the Glasses personas losing their shows' pages, this could possibly come true...
Magnum Opus: Peter claimed that readers from 2003 called "Freewheeling" his best comic, although he has released a few more contenders since then.
They Just Didn't Care: Michelle Rodriguez looks less realistic in comics from 2013 onward. This seems especially obvious in "Love Stinks (Yeah Yeah)", in which she looks normal on page 1, and crude on page 12.