"Funny Aneurysm" Moment: "What a country: heat, humidity, terrorism. Still, it's better that New York in the summertime." This joke became much darker after 9/11.
Ed's line suggesting Adrian kill himself rather than deal with his roommate becomes less funny after Robin Williams committed suicide.
In the same scene, Adrian says while impersonating Elvis Presley, "Why don't they get a rope and hang me?!" Yikes.
Harsher in Hindsight: Roger Ebert's 1988 review of this film speculates about how both Williams and his character use comedy to conceal their real selves, who seem to be extremely insecure and lacking in self-esteem underneath.
Memetic Mutation: "What a Wonderful World" would soon be used in nature films every way they could.