- Adaptation Displacement: Besides being oblivious to the original books by Hugh Lofting, many 90s kids have no knowledge of the Rex Harrison adaptation from 1967.
- Awesome Music: Louis Armstrong's rendition of "Talk to the Animals".
- Hilarious in Hindsight: Considering how Eddie Murphy would later end up playing a certain animated animal chatterbox that gets on people's nerves, seeing him at the receiving end of talking animals is definitely this.
- Tear Jerker:
- When young John loses his pet dog after his father hires a minister to perform an exorcism on John. She only attacked the minister because she thought he was threatening John. John's father sends her to the pound the next day over the misunderstanding.
- The dogs in the dog pound.
- Maya explaining to Archer that she liked the idea that John could talk to animals. Because she thinks people see her as a freak too, and thought it would be nice if she and her dad had something in common.
Dr. Dolittle 2
- "Funny Aneurysm" Moment: Hearing Steve Irwin getting his arm bitten off by a crocodile (off-screen) might be uncomfortable to watch now that he's actually dead.
- Tear Jerker: When John sees the cleared portion of the forest the animals want to save. Made worse when a squirrel who obviously used to live there comes up. It's actually rather subdued.
Squirrel: It's gone. Everything's... gone.