Accidental Aesop: You can go far and achieve your goals through drug-dealing and blackmail.
Anvilicious: Malcolm all but jumps on his soapbox and preaches near the end of the film.
Esoteric Happy Ending: It's implied that Malcolm gets accepted to Harvard, which is great, but it also means leaving his True Companion best friends, breaking up his band, and ditching the girl he just started dating.
Shameik Moore and Tony Revolori playing best friends in this movie can be this with two actors starring in their own Spider-Man movie with Moore voicing Miles Morales in Spider-Man: Into the Spider-Verse and Revolori playing Flash Thompson in the Marvel Cinematic Universe movies.
Kiersey Clemmons and Zoe Kravitz being in this movie counts as well, as Clemmons played Iris West in the DC Extended Universe and Kravitz is playing Catwoman in The Batman (2022).
Epileptic Trees: It's commonly agreed that Edsel Dope is "Xer0" for Static-X, despite Dope offering no comment.
Signature Song: Definitely, without a doubt, "Die MF Die". It has been used in everything from AMVs to interrogation music played for prisoners at Guantanamo Bay.