* HilariousInHindsight: The very same episode [[VerySpecialEpisode that tells us homophobia is wrong]] has a plot which ends with Doogie being informed by his girlfriend that "[his] charm lies in ''not'' being one of the guys."
** Also Doogie attempting to drink scotch and smoke a cigar, but getting ill. Years and years later on ''Series/HowIMetYourMother'', he's playing Barney Stinson, who smokes cigars and is a functional alcoholic.
* MemeticMutation: To this day, any person who is established and successful in a career at a much younger age than is typical is referred to as a "Doogie Howser-type".
* RetroactiveRecognition: That reporter from ''Love Means Constantly Having to Say You're Sorry''? That's ''[[VideoGame/MetalGearSolid Otacon]].''