Most Annoying Sound: Turning off the voice acting during lengthy bouts of alchemy is highly recommended, lest you start wanting to strangle Annie.
Surprise Difficulty: The game sure looks cute, doesn't it? And it has that E10 rating, right? How hard could it be? Well... make absolutely sure you pick two companions before leaving town to investigate the initial gathering sites. And make damn sure you save before checking out new ones you hear about. That's all we'll say about that.
Tear Jerker: When you find out exactly whyGillian is so obsessed with herbal health drinks, Kilbert has Fragarach and avoids the weapon store owner, and Fitz has so much trouble relating to people and why she finds Annie so remarkable.
Really, most of the character backstories and end-caps to their in-game plots are like this. The only ones who don't do it much are Beaux and, uh, Hans.