Moe Couplet: Rose and Otto. They have both so emotionally damaged that most people cannot really relate to them, but that makes their connection to each other all the deeper. They crack jokes, comfort each other, and are completely honest at all times. In his words, "Your pain touches my own".
The Woobie: Rose and Otto again. Xavier counts too, since he had to live without his best friend and later lover for long periods of time, eventually losing her altogether. And by the time he finally found her again, he was over seventy and she was still sixteen.