Genius Bonus: There are a lot of historical references in the strip, as might be expected when you have Benjamin Franklin as a primary character. One which actually gets missed a lot, though, is that Ben previously helped two people. The first, listed earlier on, was Abraham Lincoln - another is not expressly named until much later, but turns out to be Edward Murrow, a philanthropist and war reporter who made his name in 1930 and later would be an incredibly powerful reporter during the Red Scare.
Jerk Sue: The girl is getting close. Lessee: filthy rich, tells everyone to piss off like the author wishes she could, master martial artist, has an unique spirit advisor friend despite being an anonymous loner, helps the Fed get over 5 years of brainwashing, whips a cyborg's arse like an ornery mule, is currently developing empathic/precognitive powers that let her dodge bullets, can fly with the help of the ghosts and has a cool car. If this were a D&D campaign, the DM would be trying to convince her to put some advantages back. The only things stopping her from dominating the story is that she's a) still relatively grounded; b) her Fed is even more overpowered; c) they're alone against the government.
d) It's been suggested more than once that Ben's intervention is the only thing that's kept her out of jail for her antics.
Averted more recently, when she said she feels she never earned any of her powers except martial arts, and is dialing back on using them and instead becoming a doctor.