The Guild of Calamitous Intent, a trade union of Contractually Genre Blind supervillains, spans across worlds, and includes the following amongst its ranks:
- Dr. Drakken
- Señor Senior Sr.
- Bowser, King of the Koopas
- Dr. Evil
- The Riddler
- Team Rocket
- The Green Grocer
- Sideshow Bob
- Meltdown
- The Order of the Neo-Solar Temple
- The Evil League of Evil, come on, this is a gimme.
- The Brotherhood of Nod
- The Blue Meanies and their associates
- Evil Harry Dread (who calls it The Secret Society of Evil Madmen)
- The headquarters from Shadowman 9: In the Cradle of Destiny bear more than a passing resemblance to Grandville.
- Mr. McMahon
- Dr. Albert Wily
- Gideon Gordon Graves is a member, however the League of Ramona Flower's Evil Ex-Boyfriends was not officially inducted as it was decided to be classified as an "Extracurricular Activity"; and thus budgeted accordingly. He funded most of it himself.
- General William Howe
- No Heart, Shreeky and Beastly
- Dr. Ivo Robotnik, aka Dr. Eggman
- Dr. Insano
- Evil Emperor Zurg is an associate member.
- Gaston.
- The comic version of the Fraternity, though it's more of a splinter cell.
- F.O.W.L. and The Fearsome Five.
- Dr. Claw and MAD
- The '87 version of Shredder, The Foot Clan and Krang.
- And also the 2012 version of the Kraang.
