Kain's Empire

In the world of Legacy of Kain, vampires evolve over time. As fledglings they resemble your traditional pale skinned human variety, but eventually they gain talons and hooves which replace their hands and feet, and those who live a millennium, like the titular character, Kain, develop draconic skin and features, but other types of mutations can also occur.

Example of:
Our Vampires Are Different