- The Other Darrin: Julianne Grossman replaces Glenn Close as Irani Rael in this episode, while Fred Tatasciore takes over for Vin Diesel as Groot.
- Role Reprise:
- Peter Serafinowicz returns to voice Garthan Saal, nine years after last playing him in Guardians of the Galaxy. Meanwhile, Jude Law returns as Yon-Rogg four years after last playing him in Captain Marvel.
- Despite being The Other Darrin to Vin Diesel, Fred Tatasciore voiced Groot in Guardians of the Galaxy – Mission: BREAKOUT!.
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