Disowned Adaptation: The family members of Bill Tyne and Dale Murphy didn't like the movie, and sued the studio.
Name's the Same: For some unknown amount of time one of the "goofs" listed on the IMDB called the boat the Andrea Doria instead of the Andrea Gail. An understandable mistake as they are both doomed ocean-going craft that start with "Andrea" and later sank.
Separated-at-Birth Casting: Michael Ironside so greatly resembled the real-life character he portrayed (Bob Brown, owner of the Andrea Gail and her sister boat, the Hannah Boden) that, during the film's production, he was visited by a man who was looking to finish paying off a debt he'd long owed to Brown. The man in question didn't know that the real Bob Brown had passed away in 1998, over a year before the film's production started.
Throw It In!: During the funeral scene towards the end, the microphone picked up Mary Elizabeth Mastrantonio's heartbeat while she was making her speech. The director liked the effect and left it in.
Nicolas Cage was originally attached to play Bobby Shatford, but backed out due to other commitments.
Mary Elizabeth Mastrantonio was reluctant to sign on, vowing never to do another film involving water after The Abyss's nightmarish production. As all her scenes were land-based, she was persuaded to come on board.