- Creator Backlash: Quino is fond of the strip, but he stopped producing it after finding increasingly difficult to come up with gags and punchlines.
- Hey, It's That Voice!: In the original Spanish version of the animated movie, Mafalda is voiced by the same voice actress who voiced Candy White and Hajime Amamori in the Argentinian Spanish dubs of those series.
- Merchandise-Driven: Mafalda was created by Quino on commission to come up with a mascot as part of a merchandising campaign for a home appliances firm. The basic idea was to regularly publish strips in the press showing the appliances along with the characters. The campaign was canceled before it started, leaving Quino with the core characters which were recycled in the now famous comic strip.
- Unintentional Period Piece: For The Sixties. Most strips don't show it, but enough of them make enough references to place them in that time period.