- Blooper: The letter Sir Lancelot gives to Dr. Sparrow is folded into four at first, yet later is folded into three.
- Completely Different Title:
- Belgium/France/Russia: Doctor on the Loose.
- Brazil/Portugal: Don't Say, Doctor.
- Denmark: Little Doctor in Trouble.
- Germany: Help, the Doctor is Coming!.
- Finland: Doctor's Green Stubble.
- Italy: Doctor on the Move.
- Netherlands: Doctor in Freedom.
- Spain: A Phenomenal Doctor.
- Sweden: The Doctor is Loose.
- Turkey: Novice Doctor at Work.
- Creator Backlash:
- Dirk Bogarde hated the film, and only returned to the series as he was under contract. He also thought the film would struggle without Kenneth More returning as Grimsdyke.
- Richard Gordon wasn't impressed by the saucier dialogue and situations in this film compared to Doctor in the House (1954).
- Deleted Scene: A line where it is mentioned that Nurse McPherson can "make the patient without disturbing the bed" was cut from the script.
- DVD Commentary: With British comedy historian Robert Ross talking to Muriel Pavlow (Nurse Joy Gibson) and Donald Sinden (Dr. Tony Benskin).
- Fake Irish: O'Malley was played by John Chandos, a Scottish actor.
- Posthumous Credit: Ernest Jay died before the film was released.
- Referenced by...: A sign advertising the film can be spotted in the Made-for-TV Movie Night in the City.
- Uncredited Role:
- Carol Richmond as Eva.
- Barbara Roscoe as Alice.
- Donald Pickering as Cyril.
- Abe Barker as Old Ives.
- Molly Urquhart as Mrs. Ives.
- Cyril Chamberlain as a police constable.
- Author of the Doctor novels, Richard Gordon, as an anesthetist.
- We don't find out who plays Charlie Whittle, Seamus, or Muffin.
- Written by Cast Member: The screenplay was written by Nicholas Phipps, who also plays Mr. Waylands.
- You Look Familiar:
- Shirley Eaton and Maureen Pryor play different roles to the ones they had played in Doctor in the House (1954).
- Michael Medwin, Martin Benson, and Abe Barker play different roles to the ones they had played in Doctor at Sea.
- Geoffrey Keen, George Coulouris, and Cyril Chamberlain return for their third unique roles in the series.
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