The Woobie / True Blood

• Eddie, and it doesn't hurt that he's easily the most cuddly and harmless vampire we've yet seen on the show. Then sadly things went downhill.
• There's plenty on the human side of things as well. Sam had no idea what was happening to him when he started shapeshifting as a child, and his adoptive family abandoned him because of it. The flashback to Sam coming home as a child to find his house deserted and all of his family's things gone except for his is one of the most heartbreaking moments in the show.
• Tara: Abusive religious wack-a-doodle for a mom? Check. Amazing boyfriend who gets shot in the head after one season? Check. Thinking you have someone who actually cares about your well-being when you were really part of a plot to summon the god Dionysus by a screwed up Maenad who wants to kill everyone in Bon Temps? Check! Being kidnapped, held hostage, terrorized and fucking raped by a psycho yandere vampire? Check!! Oh, and to top it all off, you find out that your childhood friend/crush is the one responsible for the death of the man you loved? Forget Woobie, goddamn it. This is a cruel case of Kick the Dog.
• The sadness of Russell Edgington after Talbot's death is heartbreaking. Even if he is, you know, Russell Edgington.
• Terry Bellefleur. The man is positively gushing with Woobie qualities; his PTSD makes him gentle as a lamb; and when he reveals in Season 3 that he nursed an injured armadillo back to health, named him Felix, and now lets him sleep under his bed, you can't tell me your heart didn't melt.
• Jessica not only is turned against her will, she constantly has issues with her maker, her boyfriend Hoyt has a bigoted old hag for a mother, and on top of that her new job is almost ruined by Arlene's constant antagonizing of her. To make matters worse, Bill's behavior during the show towards Jessica is constantly neglectful as best and even later turns abusive towards her in the later seasons. This post here outlines some of the biggest problems in their relationship. Even Hoyt turns nasty towards Jessica later on and almost considers murdering her simply because she fell out of love with him. Poor girl really can't catch a break.
• Jason qualifies as well. In the first season, his girlfriend and Gran (whom he both loves) are murdered. He's blamed for these deaths by the police, despite not committing them (and even turns himself over when he believes he did). Later on, he falls for Crystal Norris, who betrays him, allows him to be kidnapped, takes part in biting him to turn him into a werepanther. If that weren't bad enough, Crystal and two dozen other women take turns raping him. It's especially Harsher in Hindsight since Jason kept his promise to Crystal to look after the werepanther community as best he could, and she still hurt him in the most horrific way possible. Don't forget he was also orphaned as a young kid, believed he was at fault for his parents dying, got beat up regularly as a kid for defending Sookie, and believed that she was dead for over a year and was left grieving for her.
• Eric after being mind-wiped by Marnie. His helpless Puppy-Dog Eyes and total awkwardness around Sookie almost makes you forget his total bastardry just an episode prior. Almost.