Richie's desperation to "cure" himself of AIDS before finally getting tested, which involves taking vitamin pills, eating disgusting foods, and at one point even considering drinking battery acid. After receiving the diagnosis he acknowledges that it's a death sentence, and as that realisation dawns on him he crosses the Despair Event Horizon.
Richie's breakdown in the car that he will never do anything. His future and all of his hopes and dreams have been taken away from him.
Colin's descent into dementia as a result of HIV given to him by his landlady’s son.
Colin's AIDS diagnosis, made worse by the fact he feels that he needs to apologise to his mother and deny being "dirty".
Richie's confession that he infected people after knowing he might have the virus, and asking Jill if she now hates him.
