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- The ending of Issue 2 can count, with Dib secluding himself in his room once again in order to hide from ridicule after Zim transmits that embarrassing video to everyone in the galaxy. Dib being wrapped up in his blankets with bloodshot eyes and looking like he's about to break doesn't help.
- Also in this issue, Gir has his legs blown off and is paralyzed, yet Zim and Dib both abandon him.
- Then there's also Zim being trapped on the Gargantis Array after Dib denied him a ride, especially after Zim even referred to Earth specifically as his home. Though to be fair, Zim did have it coming.
- Issue 5. At first, Membrane appears to be keeping up with the streak of being a decent parent to his kids... until it's revealed that he built that alternative world machine for Gaz with complete knowledge that she was going to use it to torture Dib AND participated in the kidnapping sequence.
- Taking a look at this issue from Dib's perspective makes the situation, while still the epitome of Black Comedy, freakin heart wrenching. Yes, Dib should have known by now that not only does Gaz have absolutely zero interest in his hobbies but is, in all accounts, an extremely vicious-minded individual with an extremely short fuse if interrupted. Problem is..even if Dib acknowledges and accepts that he has absolutely no one outside of her or Membrane to turn to given his circumstances. Apparently, he'll risk abandonment, ridicule, and horrific punishment trying to find support from his own family before trucking on completely alone.
- Gaz also makes herself out to be kind of a hypocrite here too. She claims that Dib was selfish for trying to get her involved with his interests, but at the same time not only is she never willing to spare him any time of her own vocation but her obsession with video games is at such a violent level that even Dib's obsession with the paranormal can't compare. And another thing, even when Dib chooses (after the fact) to try and do things that she enjoys, she STILL finds some reason to hurt him (beating Dib up because he happens to win a game fairly). In conclusion, Jhonen was absolutely right about this issue making issue 2 look tame to Dib.
- In Issue 12, Dib travels to an alternate future where Zim rules the world and eliminates the human race. Membrane's hologram message laments that the only members of their kind he was able to save were his family...except for "poor insane Dib" because Dib still wanted to fight Zim even if he had to do it alone. Even with that logic, it's obvious Membrane made no attempt to rescue his son for his own good, try to look for Dib if he was captured, or even try to assist Dib at a time where it was obvious Zim was the enemy and winning.
- In Issue 21, the main 4 cast members get their bodies switched. When Dib (In GIR's body) and Zim (In Gaz's body) realize that Gaz (In Zim's body) tricked them into getting her famous, Dib feels utterly betrayed.Dib: She played us. My own sister totally played us.
- In Issue 43, Dib is so happy that he's managed to beat Zim for the position of leader of the Plim, and starts talking about how he's going to help them improve their society and place in the galaxy... and then the Irkens show up and take over the planet. Worse, this only happens because Dib took down the anti-technology field surrounding the planet.
- A bit of Sympathy for the Devil for Zib in Issue 49. First, when it's revealed that (in contrast to his earlier claims to the main timeline Dib) defeating his Zim didn't gain him any recognition or respect, he looks so depressed. Then, at the end of the issue, he's left completely alone in the abandoned Zimvoid forever, with his last words being to beg the others not to leave him there. Of course, all this is downplayed by the fact that he destroyed his own reality and is now risking doing the same to others.
- Although over 2000 versions of Zim wound up in the Zimvoid, the Zim we know and love was the only one whose GIR wasn't killed on entry. Every other version of Zim lost his GIR in what one Zim describes as "an endless string of GIRs, trapped in a march of infinite death." Although he claims not to have missed GIR at all, it's clear that Palindrome is excited to finally have a GIR around.
- "Dookie Loop Horror" , which serves as the Series Finale.
- Just the simple fact that there is no way for the time loop to be stopped, meaning that everyone who is part of the IZ universe is trapped in the same day forever with only Zim and Dib being consciously aware of it. And that it how the story of Invader Zim ends. note
- Dib tries his very hardest to put an end to the time loop to ultimately no avail. Even when Dib destroys Gir thinking it would stop the time pig from reappearing he just respawns like nothing happened and the cycle begins again. Zim, who has already tried to end the loop himself many times over, has long given up and knows that Dib is doomed to fail.
- Given that Zim already knew getting rid of Gir wasn't going to do anything it implies that he at least once sacrificed Gir. This hits particularly hard since Zim has shown signs of being attached to his little robot side kick.
- The Hope Spot that Zim gives Dib when he claims he can fix the time loop but instead just puts a label on a button that makes a sound effect. All Dib could do is watch as the time poop gets released again and tell Zim that he hates him.
- Zim showing Dib a scrap book he made of all the times he defeated Dib when Zim was more active during the loops. Dib's soul is practically leaving his body when he sees this, especially the part where Gir baked him into a pie.
- It's implied by the last panel that Gir baked Dib into a pie yet again. Eternal reset button or not, the series just couldn't end with giving Dib a break (and, at least until the next loop, Dib can even be considered to be dead). Zim's not even happy that this happened again.
- It's also not a far fetch to view Zim taking up multiple hobbies as him resigning to his fate or coping with the circumstances.
- For Tak fans, it's shown in her panel that she's being arrested and therefore hasn't been able to become an accomplished invader and now never will. Worse is that this issue takes place after Enter The Florpus where it was said Tak escaped Moo-Ping 10 offscreen (it was deleted from the original story), meaning that she was actually caught once again.
