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Tear Jerker: Dead Space 2
Heavy Spoilers for Severed: Gabe's death in Severed. His leg is blown off and his final moments before death are fighting off a horde of Necromorphs and making damn sure his wife gets to safety before he finally dies. His final words are "I love you."
Lexine's reaction is heartbreaking.
The opening video with Nicole, while not this, adds a really huge emotional kick in the groin. Not only was her being on the Ishimura in the first place Isaac's doing (he'd encouraged her to go on the voyage because she hadn't been sure she wanted to go) and as they're talking, the video begins to cut out...and anyone who played the first game knows that communications from the Ishimura went offline a short time before the Necromorphs began slaughtering the entire ship.
At the beginning of Chapter 13 you Ellie gets on a gunship, Isaac walks over and activates it while she's on it. Before and after he does this you can tell he doesn't want to. When Ellie realized what was happening, her words, in a teary form (yes, it sounded like she was going to cry) where "...You bastard..."
Ellie: No. No! No, don't you dare, don't you dare launch this ship! ISAAC!
Immediately after that, Isaac slumps down to the ground, and Nicole is there. They have a heartfelt conversation about how he simply can't let her go, and then:
Nicole: Isaac. Touch me. Isaac: (pauses, then reluctantly stands up) ...I don't think that's a good idea. Nicole: Isaac, please. Make us whole. Isaac: (looks away) I can't.
The ending, at first. You just see Isaac, alone and miserable, just waiting to die. I was so glad to see Ellie suddenly come down to rescue him just to save him from that.
There's an Audio Log of a woman screaming at her husband in grief-stricken rage for convincing her to come with him to the Sprawl, because she had to kill her own Necromorph-ized daughter.
We do get some idea of Ellie's backstory and her reasoning for wanting to fight her way through the disaster on her own, as well as why she's so enraged at Isaac's attempted Heroic Sacrifice; she's already seen most of her crew and friends die earlier on, and the last survivor of that group performed his own Heroic Sacrifice to help her escape.