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* The writer of ''Webcomic/QuestionableContent'' is evidently aware of the trope, or at least the term, though it tends to be invoked by name rather than appearing within the plot. [[http://www.questionablecontent.net/view.php?comic=1388 The notes on this strip]] [[LampshadeHanging refer to this trope]], as does [[http://questionablecontent.net/view.php?comic=2869 the art in this strip.]]
* Ethan from ''Webcomic/CtrlAltDel'', as well as Gabe and Tycho from ''Webcomic/PennyArcade'', tend to treat their respective hobbies (Videogames and/or tabletop gaming) as SeriousBusiness, although this is probably just the authors poking fun at the "hardcore gaming" mentality.
** Additionally, [[http://penny-arcade.com/comic/2007/10/29/the-regimen/ Ping]] [[http://penny-arcade.com/comic/2007/2/16/the-onyx-obelisk/ pong]] [[http://penny-arcade.com/comic/2007/4/23/victory/ is]] [[http://penny-arcade.com/crizawl/ VERY]] SeriousBusiness.
*** ''[[http://www.penny-arcade.com/comic/2008/06/25 Now]] [[http://www.penny-arcade.com/comic/2008/6/27 a]] [[http://www.penny-arcade.com/comic/2008/6/30 major]] [[http://www.penny-arcade.com/comic/2008/7/2 motion]] [[http://www.penny-arcade.com/comic/2008/7/4 picture]] [[http://www.penny-arcade.com/comic/2008/7/7 by]] [[http://www.penny-arcade.com/comic/2008/7/9 PAX]]''.
* ''ComicStrip/ThePerryBibleFellowship'': Skub is [[http://pbfcomics.com/?cid=PBF020-Skub.gif serious business.]]
* In ''{{Triangle and Robert}}'', cooking and food is serious business. Cuisine magic powers the comic's most fearsome warriors, several of the characters have some sort of mystical cooking skill, most of them are descended from ancient lineages of battle-cooks, and it is eventually revealed that the entire universe is made out of pudding.
* ''{{PS238}}'':
-->"You have wronged innocents, Charles. I formally challenge you to a game of [[http://en.wikipedia.org/wiki/Four_square four-square]]. The loser will be given over to the lords of this realm to do with as they please!"
* Mal of ''Webcomic/HeadTrip'' warns her siblings in the tone and posture of a [[DrillSergeantNasty drill sergeant]] (even using the words "troops," "soldiers," and "mission") not to talk or make any sound whatsoever while watching the final season of ''[[Series/BattlestarGalacticaReimagined Battlestar Galactica]]''. She is dumbfounded to find that they don't in fact give a rat's behind about the show.
* Emeril [=LeGoinegasque=], a supporting character in ''{{Achewood}}'', is the president of a club dedicated to the made-up hobby of Trashspotting, driving around on garbage day and building up extensively detailed personality profiles of people they've never even met based on what they throw out. He lives and breathes trashspotting, his character blog (yes, ''Achewood'' characters get their own blogs) was all about his trashspotting exploits, and he even had a trashspotting forum for a while. To him and his club, if to nobody else on Earth, other peoples' garbage is serious business.
** Emeril's trashpotting even acts as a ChekhovsSkill in one arc, where Philippe goes missing -- he manages to figure out where he's going based off a sole discarded can of baked beans.
* In a ''WebComic/TheAdventuresOfDrMcNinja'' story, tennis was created to make sure there is always a champion to battle an ancient death machine in a game of tennis every year so it does not destroy the world. The U.S. government loses a team of Navy [=SEALs=] to the tennis temple's security system everytime they have to replace the current tennis champion. Also, they have to get through robot commando temple guards to even get to the temple.
** The entire concept is so ridiculous that the doctor, well-experienced at this sort of craziness, loses control and starts laughing hysterically.
** [[SerialEscalation Half the reason for reading it is waiting to see what he'll come up with next.]]
* In ''Webcomic/SluggyFreelance'' holidays are SeriousBusiness. Bun-Bun actually tries to take over the world by becoming the patron figure of Christmas, Halloween, Thanksgiving, etc.
* Science fiction and fantasy, and the fandom that has built up around them, are ''very'' SeriousBusiness in ''{{Fans}}''.
* Darth Maul and Marluxia have come to blows over smoothie flavors in ''AnsemRetort''.
-->'''Maul:''' [while using Force Lightning on Marluxia] Say it, bitch! MANGO STRAWBERRY!
* ''Webcomic/{{Collar 6}}'' features a BDSM society that keeps superpowered enforcers on retainer. Apparently the Judiaticizes are authorized to ''kill'' people.
** It's [[JustifiedTrope justified]] in that it's not just the enforcers who have powers. Think about this for a moment: people who enjoy hurting others and/or hurting themselves, in possession of superpowers based on whether they are sadists or masochists (or both). And not just enjoying a little, either. People who literally GET OFF from either the pain they themselves feel, or the pain that others feel. Without someone to keep them in line, how is that NOT supervillains just waiting to happen?
* In ''ProblemSleuth'', if something is [[RunningGag "Incredibly Silly"]], you can pretty much be sure it's also [[RunningGag "SERIOUS BUSINESS"]].
** In ''Webcomic/{{Homestuck}}'', the log header in John's dad's PDA declares ties to be Serious Business.
** A magazine named "Serious Jester" is for those who really ''mean'' it.
* ''SomethingPositive'' features the Teddy Bear Liberation Front. Plenty of people in RealLife find the idea of plushie fetishism weird or disturbing, but as fetishes go, it's pretty harmless. The TBLF think it's so disgusting they kill and torture people who make, sell, or use "yiffable" plushies.
* In [[http://the-qlc.com/loserz/go/413 this strip]] of ''Webcomic/{{Loserz}}'', Makkaroni with cheese are SeriousBusiness!
* In {{Nectar Of The Gods}}, bartenders are the general focus of the Webcomic, in the {{Tournament Arc}} bartending and mixing cocktails is very {{Serious Business}}! Where just drinking a specific type of drink can either fix a person's emotional problems in an instant or drive to induced suicide.
* In ''LasLindas'', Rachael feels this way about the fights in the arena. [[http://laslindas.katbox.net/?p=964 She cuts herself off before she can use this trope by name]].
* As a [[MediumAwareness self-aware cartoon character]], Karen from ''Webcomic/SketchComedy'' treats the hazards of CerebusSyndrome as Serious Business. Her anxiety is [[http://thesketchy.com/ic/2011/01/14/cerebus-syndrome played for laughs]].
* In ''{{Sinfest}}'',
** [[http://www.sinfest.net/archive_page.php?comicID=3289 fashion is serious -- with fashion police.]]
** [[http://www.sinfest.net/archive_page.php?comicID=2751 And Percy declares that Pooch can't handle the serious business of his sitting in a shoe.]]
* In [[TheRant the commentary]] of [[http://www.egscomics.com/sketchbook/?date=2010-05-18 this]] ''Webcomic/ElGoonishShive'' sketchbook strip, Dan claims that having his characters' hairstyles in flashbacks maintain continuity and be logical is serious business.
** The storyline ''Squirrel Prophet'' --which takes place in a trading-card game tournament while far more plot-important things happen at the same time-- has a sort of RunningGag where several characters think something along the lines of "focus on the card games!" [[StrangeMindsThinkAlike independently.]]
* ''WebComic/{{Precocious}}'':
** [[http://www.precociouscomic.com/archive/comic/2009/08/12 The bake sale is science!!]]
** Also, in the intro arc, a simple competition about who the better supervillain is turns into the famous "Gender Wars".
** And the arc where Mr. Et discovers that Quincy killed his WoW character...not pretty.
** [[http://www.precociouscomic.com/archive/comic/2011/04/07 '"Go Fish" is not a contact sport!']]
* Parodied with ''Manga/UltimateMopDaisukeDX'', the ShowWithinAShow from ''Webcomic/AnimeNewsNina'' about competitve janitoring.
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