- On Neon Genesis Evangelion, Shinji’s and Asuka’s Masochism Tango is disturbingly similar to that of George and Martha: Asuka is disgusted by Shinji’s lack of assertion, Martha is frustrated with George’s, attempts by either at appeasement only aggravates them further, and both of their frustrations have to do with sexual performance and assertion—Shinji won’t cross the ‘Wall of Jericho’ and notoriously settles for masturbating by her bed when she’s comatose while George is implied to be unable to perform, and both are Ambiguously Gay. Both Shinji and George ultimately both snap and lash out destructively, complete with an attempt to strangle Asuka/Martha.
- In Brothers, William Goldman's sequel to Marathon Man, when Melissa spots Babe following her, she decides to make him jealous by chatting up a younger man. When Babe catches up to her and he and Melissa start arguing, the man tells them their relationship is out of Who's Afraid of Virginia Woolf and they need to work on it while there's still time.
- The Office (US) episode "Dinner Party" was inspired by Who's Afraid of Virginia Woolf? as it shows Jim, Pam, Andy and Angela coming over for dinner at Michael and Jan's house, and having to witness the two throwing passive-aggressive jabs at each other until they spiral into Cringe Comedy madness.
Music
- Murder by Death's song titled "I'm Afraid of Who's Afraid of Virginia Woolf" takes its name from the play's title.
- Life Is Strange: Before the Storm has it mentioned that a report on the book was one of the few times Chloe did her homework after her father's death. The book itself is also seen being read by several characters throughout the game, including Rachel in the closing montage as she waits for Chloe to finish dying her hair the iconic blue colour it is in the original game.
Webcomics
- Fiona's parents in Kevin & Kell are named George and Martha after the characters in this play.
- American Dad!: The subplot of "Camp Refoogee", in which Roger and Francine roleplay as an ustable couple, is a spoof of the play.
- The Simpsons:
- In "The War of the Simpsons", Homer and Marge meet a bickering couple, who argue in a manner similar to George and Martha, at a couples retreat.
- In "Brother from the Same Planet", Homer's overdramatic confrontation with Bart about his "big brother" is based on Richard Burton's performance in the film.
- The episode "Heartbreak Hotel" features an extended spoof of the film when Homer and Marge have a falling-out, complete with black-and-white cinematography. The two younger lovers are even named Nick and Honey (with George Segal guest-starring as the former, essentially reprising his role).Homer: Our son is dead.Marge: No, he isn't!Homer: WE HAVE NO SON!Marge: YES, WE DO!Homer: (beat) Oh yeah, Bart.
- In the Pinky and the Brain episode "Brinky", Pinky contaminates Brain's clone Roman Numeral I (or Romy, for short) with an errant toenail clipping. Both treat Romy like their own child and, as Romy grows and becomes a rebellious teenager, he claims that Pinky and Brain are constantly arguing, likening them to George and Martha.Romy: Bicker, bicker, bicker! It's like "Who's Afraid of Virginia Woolf"!
