See also And Call Him "George".
- Sorrowful and Immaculate Hearts: In "Gone Fishing", Clark mentions that his parents once experimented with keeping rabbits for food, and Bruce appeals to him to "tell me about the rabbits", which Clark recognizes is a reference to Of Mice & Men.
Film - Animation
- Shark Tale: Lenny's name is probably inspired by Lennie Small. There's even a short And Call Him "George" moment with Oscar.
Film — Live Action
- Gremlins 2: The New Batch has two Gremlins named after George and Lenny. Naturally, George is a grumpy Gremlin who rarely smiles, and Lenny is a dim witted and silly Gremlin.
- Sal from On the Road quotes, "You won't tell what he done up in Weed, will you? What'd he do up in Weed? You won't tell will you? What'd he do up in Weed?" to make Terry laugh.
- In The State of Grace, the "quiet room" at Grace's school is essentially a glorified store cupboard, complete with leftover copies of Of Mice and Men.
- The Flash Tub: In a scene from Tub Bites 2 (which parodies Homestar Runner), Strong Mad "pets Marmalade too hard, now she don't move no more", leading Strong Bad to pull out a gun and "tell him about the rabbits".
- Grant Wisler's video How Internet Humor Progressively Gets Worse
includes a direct parody of the ending.
- American Dad!: The title of "Of Ice and Men" is a reference to this book.
- Animaniacs: The Rita and Runt cartoon "Of Nice and Men" is a loose Whole-Plot Reference to Of Mice & Men, with a cameo appearance by Lennie and George as portrayed by Lon Chaney Jr. and Burgess Meredith in the 1939 film version.
- Animaniacs (2020): The title of "Of Mice and Memes".
- Bungle Brothers: Joey's temperament is clearly patterned after Lennie; as such, George is his George.
- An episode of Chip 'n Dale: Rescue Rangers is called "When Mice Were Men".
- King of the Hill:
- "Of Mice and Little Green Men".
- Peggy scoffs at John Steinbeck during a performance of Of Mice and Men.
- Looney Tunes codified the And Call Him "George" trope. Willoughby the dog from The Heckling Hare (1941) and Hugo the snowman from The Abominable Snow Rabbit (1961) are based directly on Lennie.
- Leni Loud from The Loud House is named after this book's Lennie. This is fitting, as they are both unintelligent, although Leni is simply The Ditz rather than intellectually disabled. In fact, in development, Leni was going to be a Super-Strong Child who did not know her own strength, before being changed into a fashionista.
- Robot Chicken once had a sketch where characters from Rocky and Bullwinkle reenacted key scenes from the story.
- Tex Avery MGM Cartoons also revel in OM&M parodies.
- "Lonesome Lenny" is probably the ultimate example of this. "You know, I had a little friend once — but he don't move no more!". At which point Screwy Squirrel (the "little friend" in question) pulls a sign saying "Sad ending - Ain't it?" Noticeably, this is the last Screwy Squirrel Cartoon chronologically.
- Avery did a series of cartoons with George and Junior, a vaguely bear-like pair closely modeled after George and Lenny. Junior's regular screw-ups required him to bend over for George to kick his ass. This was actually the censored version. A more controversial version had Junior turning around so that George could shoot him in the head— exactly like the ending of the book it was referencing. It was presumably changed due to a case of Dude, Not Funny!.
