- Alvin and the Chipmunks: The episode "Bigger" (part of The Chipmunks Go to the Movies) is a parody of this movie.
- The Cleveland Show: In "When a Man (or a Fright Train) Loves His Cookie", the subplot of Junior posing as an adult is a parody this film.
- Family Guy:
- In "Death Has a Shadow", in flashback to when Peter saw Philadelphia after dining an Irish coffee, he recognizes Tom Hanks as "the guy from Big".
- In "The Story on Page One", Stewie sees a Zoltar machine and wishes that he was big. The machine responds with a card reading "I wish I could weigh people.""BLAST!"
- In "Papa Has a Rollin' Son", Tom Cruise, here depicted as the size of a toddler, makes a wish on the Zoltar machine to be big.
- The Simpsons: In "Lisa vs. Mailbu Stacy", Homer plays with the floor piano at Kidstown USA, but his performance of "Rock Around the Clock" ends up breaking it and annoying the other customers.
- We Baby Bears: The episode "Big Trouble, Little Babies" is a parody of this film.
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