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->''"Your upbringing made you a villain, you say? '''It didn't!!'''...You've been evil since your birth!"''
-->--'''Robert E. O. Speedwagon''' to '''Dio Brando'''

During its [[LongRunners extraordinarily long run]], ''Manga/JoJosBizarreAdventure'' has showcased a [[LoadsAndLoadsOfCharacters great variety]] of antagonists. Many are merely {{jerk|ass}}s; some are [[LaughablyEvil comical]] in their ineptitude; others still are [[AntiVillain sympathetic characters]] with [[FreudianExcuse understandable motives]] and [[TragicVillain tragic pasts]]. Then there's another breed of villain: [[CompleteMonster those who commit horrific actions with no justification]]. Here are the latter.
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* ''[[Characters/JoJosBizarreAdventurePart1 Phantom Blood]]'' (first appearance): [[BlondGuysAreEvil Dio Brando]] is the OverarchingVillain of the entire series, [[FromNobodyToNightmare rising from humble beginnings]] to become a global threat who looms large over the events of this GenerationalSaga. After [[{{Patricide}} murdering his abusive father]], Dio is taken in by the kind-hearted George Joestar and starts to covet his wealth, so Dio goes about ruining his adopted brother [[TheHero Jonathan]]'s life, attempting to [[EyeScream gouge out an eye]], stealing the [[SacredFirstKiss first kiss]] from his girlfriend Erina, and [[KillItWithFire burning his beloved dog alive]]. Dio later poisons George in an attempt to claim his inheritance, and after [[HopeSpot being thwarted]], stabs him fatally as a blood sacrifice to activate the [[ArtifactOfDoom Stone Mask]] and become a vampire. Dio then [[TranshumanTreachery renounces his humanity]] and sets up a base in a nearby medieval town, draining its inhabitants of life one-by-one. When a mother agrees to let Dio zombify her on the condition that he doesn't lay a hand on her baby, he watches with amusement as [[ExactWords the zombified woman eats her own child]]. After being defeated by Jonathan and reduced to a disembodied head, Dio stalks and murders Jonathan on his honeymoon cruise, taking a boat full of innocent people down with them, before [[BodySnatcher stealing Jonathan's body]]. Returning in [[Characters/JoJosBizarreAdventurePart3 Part III]], Dio tries to prevent Jotaro and his friends from reaching him by having [[ProfessionalKiller Gray Fly]] bring down the passenger plane they're on, and murdering his loyal [[TheDragon right-hand woman]] Enya Geil to ensure that she doesn't divulge his powers. In the climactic confrontation with Jotaro and company, Dio abducts a man, forces him to drive at lethal speeds through crowds of pedestrians in pursuit of his foes, and then kills him by [[GrievousHarmWithABody using him as a projectile]]. [[Characters/JoJosBizarreAdventurePart6 Part VI]] reveals details about the now-deceased Dio's grand plan: he manipulated his fanatically loyal follower Enrico Pucci into seeking to [[RealityWarper rewrite reality]] into Dio's warped vision of "heaven", meaning nothing but [[AGodAmI unchecked power]] for Dio and more grovelling support from his underlings.
* ''[[Characters/JoJosBizarreAdventurePart3 Stardust Crusaders]]'':
** [[BaldOfEvil J. Geil]] stands out as one of the [[LovesTheSoundOfScreaming vilest]], and most [[{{sadist}} sadistic]], of the minor villains encountered by Jotaro and his friends. Driven by a [[{{Ephebophile}} lust for teenage girls]], he {{rape|Is A Special Kind Of Evil}}d and [[WouldHurtAChild killed]] the young Sherry Polnareff (and attempted to murder her friend as well, succeeding in the {{OVA}}), prompting her brother Jean Pierre to join the heroes and seek revenge. He [[EvilGloating boasts]] that she was just one of countless girls that he [[SerialRapist raped]] and [[SerialKiller killed]]. When confronted by Polnareff and Kakyoin, he shows himself to be a [[DirtyCoward coward]] of the highest order, [[HumanShield placing]] his [[FightingSpirit Stand]] in [[MirrorMonster the eyes of a little boy]] and telling his opponents that they'll never reach him without [[EyeScream gouging out the boy's eyes]]. When this fails, he escapes and inflicts grievous (possibly fatal) wounds on a man to dress him up as a decoy for a [[InTheBack sneak attack]]. Finally, he attracts a crowd of at least 10 people, then hides his Stand among them before trying to goad Polnareff to mow them down by gloating about what he did to his sister. He dies showing nothing but pride in his actions.
** [[PsychopathicManchild Terence (Telence) T. D'Arby]]/[[DubNameChange D'Arby the Younger]] is the [[FauxAffablyEvil courteous and formal]] butler of Dio Brando. After introducing himself to the heroes and trapping them in his basement, he reveals his true colors, proudly displaying his collection of [[LivingDollCollector 15 dolls]], all people who he defeated in a game before taking their souls. Unlike his brother Daniel, he deliberately keeps them [[AndIMustScream fully aware of their situation and powerless]]. He then defeats Kakyoin and adds him to the collection, intending to do the same to Jotaro and Joseph. He also gloats about an incident where he beat his brother Daniel to near-death after catching him flirting with his girlfriend.
* ''[[Characters/JoJosBizarreAdventurePart4 Diamond Is Unbreakable]]'': Anjuro "[[IronicNickname Angelo]]" Katagiri is a SerialKiller and Japan's most notorious criminal. A robber and rapist since the age of 12, his infamy reached its peak after an incident in which he raped and killed two teenage boys before taking a third one hostage. He arranged a ransom with the boy's rich parents, but revealed at the exchange that he had [[GroinAttack cut off the boy's penis]] and killed him, and then [[CopKiller killed one of the policemen]] who came for him. After escaping prison, Angelo [[GrandTheftMe body-jacked]] a man, took a woman hostage at knifepoint and tried to stab her to death in a fit of pique. After Josuke thwarts him, he goes on a killing spree with 7 civilian deaths. He attempts to kill Josuke and [[MisplacedRetribution his mother]] out of spite, and then kills Josuke's grandfather. He returns for another attempt on their lives, and when defeated, he taunts Josuke with his grandfather's death and the fact that he can't kill Angelo [[IfYouKillHimYouWillBeJustLikeHim without becoming like him]], before threatening to [[WouldHurtAChild throttle a young boy to death]].
* ''[[Characters/JoJosBizarreAdventurePart5 Vento Aureo]]'' ("Golden Wind"):
** Diavolo, the BigBad of ''Vento Aureo'', is the mysterious [[TheDon "boss"]] of [[TheMafia Passione]], who was ruthless enough to be able to edge out all the other Mafia families. However, he causes his more conscientious employees to rebel by rejecting the ethics adhered to by other mafiosi and selling hard drugs to minors. Driven by extreme paranoia, he resolves to erase all traces of his past identity and kill anyone who has seen his face. Years ago he attempted to [[{{Matricide}} kill his mother]] by sewing her mouth shut (a torment he later inflicts [[WouldHurtAChild on a young boy]]) and [[BuriedAlive burying her alive]]. He then [[WhereIWasBornAndRazed burned his village to the ground]], intending to kill everyone and [[FakingTheDead being listed as a casualty]]; at least seven people are killed by this, and Diavolo intended to kill more. He rules his organization with an iron fist and makes a gruesome example of two of his elite assassins when they breach his privacy. He dismembers one of the men alive-which causes the other to commit suicide to avoid a similar fate-and then sends the bodies to their comrades as a macabre warning. When he learns that he has a teenage daughter, he responds by [[OffingTheOffspring plotting to murder her]], almost doing it himself before Bruno intervenes. Additionally, it was Diavolo who sold the [[ArtifactOfDoom Stand Arrows]] to Enya Geil, making him responsible for the outbreak of [[SuperEmpowering super-empowered]] villains that has driven the events of the series from Part III onward. Heartless, paranoid and grandiose, Diavolo believed himself to be a rightful emperor over the whole world and stopped at nothing in pursuit of power.
** [[PsychoForHire Cioccolata]], the most {{sadist}}ic member of Passione, is a SerialKiller whose main joy in life is [[LovesTheSoundOfScreaming seeing pain and fear expressed on the face of someone about to die]]. He [[MadDoctor volunteered in aged care]] for the chance to torture vulnerable people to death, poisoning them and [[BreakThemByTalking breaking their spirits]] by telling them that no-one would come to visit them. From this cruelty [[PersonalityPowers was born]] a [[BadPowersBadPeople gruesome power]]: his Stand inflicts people with mold that causes them to [[CruelAndUnusualDeath die in agony]] as [[BodyHorror their bodies fall apart]]. He had used this power to kill innocents for years by the time he was introduced. While waiting to ambush the heroes, he kills several bystanders in this way. Rather than finishing off his targets while they're at his mercy, he waits while his similarly depraved partner Secco records their anguished expressions for posterity [[VillainBall (enabling their escape)]]. He then takes a helicopter to pursue his foes and kills everyone else in sight. As a {{sadist}} unconstrained by morality and reason, Cioccolata earns the contempt of everyone he encounters.
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