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- In the Star Comics version of Masters of the Universe, only He-Man/Prince Adam could touch the Power Sword, as it would deliver a painful magical blast to any other living being — including He-Man's fellow heroes. Inorganic beings such as the Horde Troopers were unaffected, though. It should be noted, however, that this, along with pretty much all of the Star Comics. falls under Canon Discontinuity.
- In Time Bandits, Kevin warns his parents not to touch a piece of Evil that the dwarves didn't dispose of. They (as usual) don't listen to him. Boom.
- The MacGuffin from the 1985 Red Sonja movie is lethal to any male who touches it.
- The Phlebotinum in Mystery Team.
- Blade's sword has a rather nasty security feature on it, just in case Blade's prey get any ideas about using his weapon against him.
- In The Jackal, the titular assassin sprays something on his SUV that was holding his gun as a would-be thief was tailing him. He somehow dies from whatever it was.
- In Guardians of the Galaxy the infinity stone has a tendency to quickly damage and then kill those who attempt to wield it without proper precautions. Luckily carrying cases that can contain it seem to be pretty easy to procure.
- In Gone, touching the barrier feels like sticking your entire arm in an electrical outlet.
- In The Dresden Files, Mordite is a kind of corporealised mortality. Just getting near it can be lethal.
- The Sword of the King of the Enchanted Forest feels uncomfortably hot to anyone not in the King's family line.
- The Agiels in The Sword of Truth series automatically cause pain to whoever touches them, including the wielder. The degree of pain, and whether they cause physical injury, can be adjusted.
- In The Black Company, a man tries to pick up Sealed Evil in a Can by hand and the sheer evil of it gives him a 3rd degree burn that won't heal.
- Silmarils will burn anyone who takes them that is not good enough to hold them.
- In the original version of Aladdin (the story, not the Disney movie), Aladdin is warned to not touch anything in the place where the lamp is being held. He is warned that if his clothes so much as brush the walls, he'll be killed.
- In Theodore L. Thomas' The Clone, the eponymous life form is a giant blob of organic matter that inhabits the sewage system and dissolves any organics it touches into water and food for itself. The worst part of it? It doesn't hurt at all, so you won't even notice it until half your leg is gone.
- In the Lensman series, a Lens will instantly kill whoever touches it if that person isn't its owner. We see a few cases where someone other than the owner handles a Lens (usually another Lensman), but it's always with insulated forceps, gloves, and containers.
Live Action TV
- The forcelances in Andromeda are equipped with DNA-recognition keys. They're 'supposed' to deliver an electric shock large enough to make an unauthorized user let go, but Harper likes to tinker with the charge.
- In Babylon 5, a researcher who touched the surface of a Shadow vessel was described as having died instantly as if the life had just been sucked out of him.
- Some magical items in Dungeons & Dragons will automatically inflict damage on anyone of the wrong alignment who picks them up. A few are safe to handle initially, but trying to invoke their power if you're the wrong alignment/class/whatever will cause damage to hp, xp, or abilities.
- A version of this mechanic also shows up in NetHack.
- In one episode of South Park, Cartman claims his super-high-tech Trapper Keeper will impale any hand whose fingerprints don't match his. Kyle doesn't believe this, but decides not to touch it when Cartman gives him a chance to debunk the claim. The show being what it is, we later see that Cartman was telling the truth.
- In Harry Potter and the Unspeakable, the wand which Harry obtained from Ollivander's, made of meteorite and dubbed the "Celestial Wayfarer," was said to be harmful to any evil person who touched it. A particular character was later revealed to be Snape's evil stepfather on Polyjuice when he was forced to pick up the wand while in court and it burned his hand.