Dante's reaction to Trish breaking into his office on bike. And then the first thing he assumes is that she's just looking for a toilet.
Dante's cocky attitude in general. A giant lava spider-scorpion thing? He just knocks on its shell saying how he hopes there's "something inside that big body" of his.
The scene where the bridge breaks while Dante is suddenly struck by lightning in crossing it. It's so Wile E. Coyote-esque, it's hilarious. The only thing missing is the "Yikes!" sign.
And after the fight against Griffon, there's the scene leading up to his death. The way his body starts to magically ascend to the heavens before being crushed by a pillar is absolutely hilarious.
After Dante returns to the castle, he often notes how the doors that were there before had vanished "due to evil powers". In some cases, you almost can feel the snark.
Dante: (after inspecting where the door should be) "The door's been vanished due to evil powers. Scary..."
In fact, when you first enter the castle at the beginning of the game, Dante will often express his absolute disinterest in everything of note he inspects. In particular, this is his reaction to the suspicious-looking statue. Said statue is actually Mundus. Dante just insulted the Big BadSatanic Archetypewithout even realizing it.
Dante: (Inspecting a statue) "This must be a statue of a deity the islanders worshipped. Yeah, whatever."
Examining the various books scattered around the castle will prompt Dante to briefly describe their contents... only to question why he's reading them in the first place.
Dante just can't hide his excitement when he inspects the portal to the Underworld.
After Dante finally blows Mundus out of the human world thanks to Trish's help, the Demon King boasts that he will return and rule this world. Dante quickly quips back against Mundus' attempt at returning with this line:
Dante: Goodbye! And when you do come back, give my regards to my son, will ya?
According to Hideki Kamiya, the dragon that Dante summons against Mundus is named Puff. Yes, this is a real post. The hilarious thing about this is that Dante is definitely immature enough to name an eldritch monster tamed by Sparda something like Puff. However, a portion of the fandom prefers to take it with a grain of salt, given Kamiya's tendency to make jokes in between providing serious answers.
The hilarious thing about this is that Dante is definitely immature enough to name an eldritch monster tamed by Sparda something like Puff. However, a portion of the fandom prefers to take it with a grain of salt, given Kamiya's tendency to make jokes in between providing serious answers.