- Tyne Daly's pregnancy was written into the show. In one episode during that time, Cagney and Lacey are out on the street and happen to notice a guy stealing a TV from an apartment—in broad daylight. At first they're amused at his sheer gall, and they shout jeers at him ("Hey, Mr. Television!"), but he winds up giving them a serious chase and they nearly lose him. That's until a hormonal Lacey rounds a corner and screams at him to stop, terrifying not only the perp but a shocked Cagney as well.
Lacey (as they take the perp into custody): I can't run like I used to, Christine.Cagney: You're a dangerous woman when your feet hurt, Mary Beth.
- When a local game show is suspected of fraud, the detectives (Cagney, Lacey, Isbecki, and Esposito) investigate it disguised as contestants. Since it's sort of a blend of Jeopardy! and Let's Make a Deal, they wind up wearing costumes reminiscent of a Fruit of the Loom commercial, much to their disgust. Cagney lets the host know the jig is up when he asks her a game question and she replies by lifting up one of her pineapple "spines" to reveal her badge.
Cagney (big, game-show smile): This is a bust, Bob!
- During the opening titles, Cagney and Lacey are marching a perp through the streets when a man in a trenchcoat flashes them to which Lacey says something that is inaudible due to the overdubbed music. After an intrigued viewer asked what was said, the series producers provided the original clip to a TV show answering viewers questions which revealed that that Lacey said:
"Put that thing away, you don't know where it's been!"