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troperville

Lyle pukes on a football. Hard enough to make it go three feet.
Lyle: I spiraled it, by the way. That doesn't just happen by not caring.
"You would cut off your own face if people thought you lost a fight to me." Envelop� would also put his kids into the Witness Protection Program for them to escape the shame. As the alt-text says, "Ray Smuckles is definitely known locally as a dude you don't want to have lost a fight to."
On the army they've amassed in the GOF:
Ray: Beef, why do I get the feeling that our army's made of ex-kids who were always picked last for kickball?
Roast Beef: Can you think of anyone who has a more gigantic and deep-seated fury at the world"
The way Todd enters the North Korean Magical Realism Text Adventure world... by pissing up a rope, after being told to do so by an irate Tacodore.
Come on.
Pat's gayness: exposed!
Most of the comments can qualify as a crowning moment of funny. It's like a little, self-contained world of hilarity.
- Sadly, with the death of Assetbar in 2012, they may truly be Lost Forever.
Spy Ware, the first appearance of Ray's fetish.
Ray spending his time at the library... in the true Ray Smuckles Way.
Teodor finds the guy who made Comic Sans. Asskicking ensues.
Philippe's 5th Birthday Party, in which Todd does a lot of coke (or does he?)
Ray Gets Sort of Stoned and its companion, Ray is high under the table.
"Magic Underpants Finale", for starting the whole "x... is... rad!" meme.
Roast Beef tries to kill a chicken humanely.
The Subway Wars. Several characters start up Subways joints in the area, and things come to a head when Pat resorts to dirty tactics to get Lyle shut down. Vlad looks at Pats website (yes, Pat actually build a website for his Subway, complete with message board). Vlad, appalled by both the tacky web-design (including embedded MIDIs) and Pat's general arrogance, gets into a Flame War with Pat. Pat finally figures out how to ban Vlad, but the robot has the last laugh; he crack the site and turns it into a haven for white supremacists.
On the topic of funny arcs, how about the brief storyline where Little Nephew tries to establish a world record by (very) slowly driving a 1973 Honda Civic into a lake, with the Running Gag of Ray conspicuously missing the round-the-clock news coverage?