The series takes place in a fictional South American country, but many of the main characters have decidedly Japanese first names. This actually makes sense considering the country is based on Brazil, which has the largest Japanese population outside of Japan itself.
Hana's homelife. It's a horrible existence, and worst of all when you watch it, you realize that you probably have people who are treated like that in real life.
All the vicious gangs of children running around. Where are the parents and why are they so violent?