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* While the ''Franchise/AceAttorney'' series prefers using duos or trios, the investigation team from case 3-5 fits perfectly: [[WhipItGood Franziska]] (choleric), [[TheComicallySerious Edgeworth]] (melancholic), [[MustHaveCaffeine Godot]] (phlegmatic), and [[InspectorLestrade Gumshoe]] (sanguine).
* ''VideoGame/AngryBirds'': Blackbird (choleric), White-bird (melancholic), Redbird (phlegmatic), and Yellow-bird (sanguine).
* The four spirits of the Book of Prophecy in ''VideoGame/AvalonCode'' can be identified as this: Rempo (choleric), Ur (melancholic), Neaki (phlegmatic), and Mieli (sanguine).
* In ''VideoGame/BaldursGate2'', your party in the initial dungeon contains the cheerful, light-hearted, impulsive Imoen (Sanguine), the hot-headed, highly motivated, rage-harnessing LargeHam Minsc (Choleric), the cautious, sarcastic, grieving widow Jaheira (Melancholic) and the easy-going yet reserved Yoshimo (Phlegmatic).
* In ''VideoGame/BlazeUnion'', the first five party members: Garlot (choleric), Jenon (melancholic), Medoute (phlegmatic), Siskier (sanguine), and Aegina (leukine). And after the party dynamics suffer an upheaval, things shake down like so: Gulcasa and Leon (choleric), Nessiah (melancholic), Baldus (phlegmatic), Emilia (sanguine), and Aegina is... still leukine.
* ''VideoGame/{{Borderlands}}'': Mordecai (melancholic), Lilith (phlegmatic), Roland (choleric), and Brick (sanguine).
** ''VideoGame/{{Borderlands 2}}'': Axton (sanguine with a bit of choleric), Maya (melancholic), Salvador (choleric), Zer0 (phlegmatic). With DLC, there's also Gaige and Krieg, who are Sanguine and Choleric respectively. The Hyperion counterparts are: Handsome Jack (choleric), Mr. Blake (melancholic), Professor Nakayama (sanguine), [[spoiler:Angel]] (phlegmatic).
** ''VideoGame/BorderlandsThePreSequel'': Athena and Timothy (phlegmatic), Nisha (sanguine), Wilhelm and Aurelia (melancholic), Claptrap (choleric).
* ''{{Catherine}}'', in terms of Vincent and his three bros that he hangs out with at the Stray Sheep. Orlando (choleric), Jonny (melancholic), Vincent (phlegmatic), and Toby (sanguine).
* ''{{VisualNovel/Dangan Ronpa}}'''s students:
** Sanguine: Asahina, Junko, Leon and Sayaka.
** Choleric: Ishimaru, Togami and Mondo.
** Melancholic: Kirigiri, Yamada, Fukawa and Sakura.
** Phlegmatic: Celes, Hagakure, Chihiro and Naegi.
** Leukine: Chihiro could also be considered this.
* ''{{VisualNovel/Super Dangan Ronpa 2}}'':
** Sanguine: Hanamura, Mioda, Souda and Saionji.
** Choleric: Kuzuryuu, Nidai, [[spoiler:Togami]] and Owari.
** Melancholic: Hinata, Koizumi, Pekoyama and Gundam.
** Phlegmatic: Komaeda, Nanami and Sonia.
** Leukine: Tsumiki.
* DonkeyKongCountryTropicalFreeze: Donkey Kong (melancholic), Diddy Kong (sanguine), Dixie Kong (phlegmatic), and Cranky Kong (choleric).
* The LoveInterests in ''VideoGame/DragonAgeII'': Isabela (sanguine), Merrill (choleric), Anders (melancholic), Fenris (phlegmatic with a dash of melancholic).
* The party in ''VideoGame/DragonQuestVIII'': [[TheHero Hero]] (phlegmatic), Yangus (sanguine), Angelo (melancholic), and Jessica (choleric)
* The four playable characters of ''{{Drakengard}}'', though at times they muddle about with their humors, tend to fall into distinct ones: Arioch (sanguine), Caim (choleric), Leonard (melancholic), and Seere (phlegmatic).
* [[TheChosenMany The Chosen Four]] of ''VideoGame/EarthBound'': Ness (choleric), Poo (melancholic), Jeff (phlegmatic), and Paula (sanguine).
** Likewise the Applechasers of ''VideoGame/CognitiveDissonance'' has [[TheHero Alinivar]] as sanguine, [[TheLancer Colonel Saturn]] as choleric, [[TheBigGuy Larice]] as melancholic, [[TheSmartGuy Zarbol]] as phlegmatic and [[MentorArchetype Niiue]] as leukine.
* ''VisualNovel/FateStayNight'' has Rin/Archer (choleric), Shirou/Saber (melancholic), Sakura (phlegmatic), and Rider (leukine).
* ''VideoGame/FinalFantasyVI''
** Melancholics: Celes, Shadow, and Cyan
** Sanguines: Edgar, Relm, and Setzer
** Cholerics: Locke, Mog, Sabin, and Kefka (with a bit of sanguine).
** Phlegmatics: Terra, Leo, Gau, and Strago
* ''VideoGame/FinalFantasyIX'''s first party: Steiner (choleric), Vivi (melancholic), Garnet (phlegmatic), and Zidane (sanguine).
* ''VideoGame/FireEmblemAwakening'': The five major characters; [[TheHero Chr]][[BewareTheNiceOnes om]] (choleric), [[GenkiGirl Lissa]] (sanguine), [[CharClone "Marth"]][[spoiler:[[KidFromTheFuture AKA]] [[BrokenBird Lucina]]]] (melancholic), [[FourStarBadass Frederik]] (phlegmatic), and [[PlayerCharacter The Avatar/Robin]] (leukine).
* ''VideoGame/FrontMission'': Canyon Crow and close allies:
** Choleric: [[BloodKnight Gregorio]], [[spoiler:[[CoolOldGuy Alder]]]], and [[spoiler:[[TheLancer Gentz]]]]
** Choleric and melancholic: [[RulesLawyer Natalie]] and Maury/Molly
** Melancholic: Commander ([[KnightTemplar Royd]]/[[ByronicHero Lloyd]]/[[HelloInsertNameHere custom name]]), [[spoiler:Bobby]], and [[spoiler:Dr. Brown]] (moral support only)
** Phlegmatic: [[TheIdealist J.J., Paul]], and [[spoiler:General Blakewood]] (moral support only)
** Phlegmatic and Sanguine: [[ManChild Peewie]], Yang (Meihua), and [[GentlemanAndAScholar Hans]]
** Sanguine: [[BoisterousBruiser Keith]], Frederick, and [[spoiler:[[TheMcCoy Porunga]]]]
** Leukine: [[TheSmartGuy R. Sakata, Yeehin]], and [[spoiler:[[TheStoic Ralph]]]].
** The [[FourIsDeath Big Bad quartet]] (counting a BigBad from USN mode): Driscoll (sanguine), [[spoiler:[[TheMole Olson]]]] (choleric/melancholic), Patrick Wingar (phlegmatic), and [[spoiler:Koichi Sakata]] (leukine).
* ''VideoGame/GearsOfWar'''s Delta Squad are like that: Marcus Fenix (choleric), Damon Baird (melancholic), Dominic Santiago (phlegmatic), and Augustus Cole (sanguine).
* ''VideoGame/GrandTheftAutoIV'': The four main characters fit: Brucie (choleric), Niko (melancholic), Little Jacob (phlegmatic), and Roman (sanguine).
* ''VideoGame/GrandTheftAutoV'': The Main Characters Epitomise all the Temperaments each. Trevor (choleric), Michael (melancholic), Franklin (phlegmatic), Lamar (sanguine) and Lester (leukine).
* The female leads of the visual novel ''GSenjouNoMaou'' are a picture-perfect example: Haru (choleric), Mizuha (melancholic), Tsubaki (phlegmatic), and Kanon (sanguine).
* ''VideoGame/KidIcarusUprising'':
** Pit (sanguine), Lady Palutena (phlegmatic), Magnus and Dark Pit (choleric/melancholic).
** The Forces of Nature: Viridi (choleric), Cragalanche (leukine), Arlon the Serene (melancholic/phlegmatic), and Lightning Flash Phosphora (sanguine/choleric).
** The Underworld Army: Medusa (choleric/melancholic); Twinbellows, Dark Lord Gaol, Hewdraw and Great Reaper (leukine), Pandora (phlegmatic), Thanatos (sanguine) and [[spoiler: Hades]] (sanguine/phlegmatic).
* The playable characters of ''VideoGame/KirbysReturnToDreamLand''. King Dedede (choleric), Meta Knight (melancholic), and Waddle Dee (phlegmatic), and Kirby (sanguine).
** In ''VideoGame/Kirby64TheCrystalShards'', we have Kirby (sanguine), Waddle Dee (phlegmatic), Ribbon (melancholic/phlegmatic), Adeleine (leukine), King Dedede (choleric), and the Fairy Queen (choleric/phlegmatic).
* Both ''VideoGame/Left4Dead'' and ''VideoGame/Left4Dead2'' star a four-man (or, technically, three-man and [[TheSmurfettePrinciple one-woman]]) band. In the first: [[JerkWithAHeartOfGold Francis]] (choleric), [[CoolOldGuy Bill]] (melancholic), [[TheChick Zoey]] (phlegmatic), and [[NiceGuy Louis]] (sanguine). In the second, [[TeamDad Coach]], [[DeadpanSnarker Nick]], [[SassyBlackWoman Rochelle]], and [[CloudCuckoolander Ellis]] for the most part fill those roles respectively, though Ellis is the most clean-cut/consistent.
* The four forms, or, more precisely, [[SoulJar the people the transformation masks come from]] in ''MajorasMask'' look to fall into this decently as well. Darmani is/was choleric; the [[TheWoobie Woobie]]-like Deku Kid is/[[PosthumousCharacter was]] melancholic; Link, TheHero, gets to be phlegmatic; and Mikau is/was sanguine.
* Due to the author being interested with the subject, ''{{MARDEK}} RPG'' does this. The author believes everyone has a primary and a secondary temperament, though. Perhaps the clearest ingame example is Legion: [[spoiler:a construct created by an inventor. It was animated with dark magic, with the inventor saying the incantation - due to his stuttering, though, four souls entered the body instead of one - one for each temperament]].
* The major ''MarioAndLuigi'' antagonists: Cackletta, Princess Shroob, Bowser (choleric); Fawful (sanguine), Dark Star (melancholic), Antasma (phlegmatic), [[spoiler: Elder Princess Shroob]] (leukine)
* ''VideoGame/MarioAndLuigiDreamTeam'':
** Mario (choleric), Luigi (melancholic), Starlow (sanguine), Prince Dreambert (phlegmatic)
** Big Massif and his Hooraw disciples: Sorrow Fist (melancholic), Beef Cloud (phlegmatic), Heavy Zest (sanguine), Thunder Sass (choleric) and Big Massif himself (leukine).
* ''Videogame/MassEffect2'' has the starting four. Shepard (choleric), Miranda (melancholic), Jacob (phlegmatic), and Joker (sanguine).
* ''Videogame/MassEffect1'' and ''Videogame/MassEffect3'' squads are often comprised this way: Shepard and Javik(choleric), Garrus and Liara (melancholic) and Tali and EDI (phlegmatic). Likewise, James and Ashley (sanguine) and Kaiden (neutral phlegmatic).
* ''Videogame/MegaManClassic'' series: Rock/Mega Man (phlegmatic), Proto Man/Blues (melancholic), Forte/Bass (choleric), Roll (sanguine), and Duo (leukine).
** The Robot Masters from Videogame/MegaManPoweredUp: Fire Man and Oil Man (choleric), Guts Man and Time Man (melancholic), Cut Man and Ice Man (phlegmatic), and Elec Man and Bomb Man (sanguine).
* ''Videogame/MegaManBattleNetwork'': Dex and his Navi [=GutsMan.EXE=] (choleric), Chaud and Glyde.EXE (melancholic), Mayl and [=MegaMan.EXE=] (phlegmatic), Yai and her Navi Roll.EXE (sanguine), and Lan (leukine).
* ''Videogame/MegaManX'' Maverick Hunters, counting the navigators in X8: The fast-action AntiHero Zero (choleric), the conscientious defender X (melancholic), the flamboyant Axl (sanguine), The optimistic fatherly Signas (phlegmatic/sanguine), Alia (choleric/melancholic), Palette (phlegmatic), and Layer (leukine).
** The villains: Vile is choleric ([[{{HairTriggerTemper}} and dang!!]]); [[spoiler:Lumine]] is melancholic; Dynamo is sanguine; and Sigma is leukine.
** ''Videogame/MegaManX2's'' X-Hunters, plus the BigBad Sigma: Violen (choleric), Agile (melancholic), Serges (phlegmatic/sanguine), and Sigma (leukine).
** Capcom never made clear whether classic Rock/Mega Man is the same Mega Man as X. If they are the same, Mega Man underwent a '''''major''''' temperament change. [[note]]Some may argue that the melancholic side to him simply got brought to clearer [[JustForPun light]] as Mega Man got infused with human feelings.[[/note]]
* ''{{Mega Man Zero}}'': The [[AFatherToHisMen motherly-toward-the-team]] Ciel (phlegmatic/melancholic) and Zero (choleric as usual).
** Among the Four Guardians: The leaderly and loyal Phantom (leukine), the [[TheDeterminator indeterrable]] and TriggerHappy Fefnir (choleric), the virtuous and civil Harpuia (melancholic), and the calm-but-playful Leviathan (phlegmatic/sanguine).
*** [[spoiler:A duplicate was made of X]], but not quite the same temperament, and a lot less mature.\\
Other bosses in first two games:
** Choleric/melancholic: Copy-X in 1st, Phoenix Magnion ([[PlayingWithFire element corresponds]]) and Hyleg Ourobockle in 2nd
** Phlegmatic: Herculious Anchortus in 1st, Poler Kamrous ([[AnIcePerson element corresponds]]) and Burble Hekelot in 2nd
** Sanguine: Maha Ganeshariff in 1st, Panter Flauclaws ([[ShockAndAwe element corresponds]]) and [[spoiler:Elpizo]] in 2nd
** Leukine: Phantom in 1st, Kuwagust Anchus in 2nd
*** X-Series enemies holographed by Phoenix Magnion in ''Zero 2'': Vile (choleric), Agile (melancholic), Colonel (sanguine/phlegmatic), and [[FlatCharacter Bit]] (leukine).
* ''VideoGame/{{Metroid}} [[VideoGame/MetroidPrime Prime 3: Corruption]]'': Samus (leukine), Rundas (choleric), Ghor (melancholic), and Gandrayda (sanguine).
** In Temperament, Gandrayda alone fits her respective weapon element (electric -- sanguine).
* The Sons Of Big Boss in ''MetalGearSolid'': Liquid Snake (choleric), Decoy Octopus aka DARPA chief/Vulcan Raven (melancholic), Sniper Wolf (melancholic/phlegmatic), Revolver Ocelot (phlegmatic/sanguine), Psycho Mantis (sanguine/choleric).
* The Dead Cell Unit in ''MetalGearSolid2'' applies: Solidus Snake (choleric), Fortune (melancholic), Vamp (phlegmatic), Fatman (sanguine).
* The Cobra Unit in ''MetalGearSolid3'' applies: The Pain/The Fury (choleric), The Boss/The Sorrow (melancholic), The End (phlegmatic), The Fear (sanguine).
* The Beauty and the Beast unit in ''MetalGearSolid4'' applies: Raging Raven (choleric), Crying Wolf (melancholic), Screaming Mantis (phlegmatic), and Laughing Octopus (sanguine).
* ''NaziZombies'': Tank (choleric), Takeo (melancholic), Nikolai (phlegmatic), and Richtofen (sanguine).
* ''VideoGame/{{NieR}}'' features has something of this as well. Nier (choleric), Emil (melancholic), Grimoire Weiss (phlegmatic), and Kaine (sanguine).
* Judging by their programmed natures, the ''PacMan'' ghosts:
** Choleric and melancholic: Pinky (chases and ambushes)
** Phlegmatic: Inky (cautious)
** Sanguine: Blinky (cocky, always chases)
** Leukine: Clyde (indifferent and random)
* Intentionally invoked in ''Videogame/PlanescapeTorment''. [[spoiler:In the end game, you meet up with three copies of yourself, who are the good incarnation (melancholic), crazy incarnation (sanguine) and pragmatic incarnation (choleric). The character of the protagonist depends on how you've been playing him, but he does start out as phlegmatic]].
* The various Gym Leaders from the {{Pokemon}} games:
** Kanto: Lt. Surge and Blaine (choleric), Sabrina and Janine (melancholic), Brock and Erika (phlegmatic), and Misty and Blue (sanguine).
** Johto: Chuck and Clair (choleric), Morty and Pryce (melancholic), Falkner and Jasmine (phlegmatic), and Bugsy and Whitney (sanguine).
** Hoenn: Flannery and Winona (choleric), and Norman and Juan (melancholic), Roxanne and Lisa/Tate (phlegmatic), and Brawly and Watson (sanguine).
** Sinnoh: Crasher Wake and Byron (choleric), Fantina and Volkner (melancholic), Roark and Maylene (phlegmatic), and Gardenia and Candice (sanguine).
** Unova: Chili, Clay, Lenora,and Roxie (choleric), Cress, Drayden and Brycen (melancholic), Cheren, Cilan and Elesa (phlegmatic), Burgh, Iris, Skyla and Marlon (sanguine).
** Kalos: Korrina and Wulfric (choleric), Grant and Olympia (melancholic), Ramos and Clemont (phlegmatic) and Viola and Valerie (sanguine).
* Similarly, the Elite Four:
** Kanto: Lance (choleric), Agatha (melancholic), Bruno (phlegmatic), and Lorelei (sanguine).
** Johto: Karen (choleric), Koga (melancholic), Bruno (phlegmatic), and Will (sanguine).
** Hoenn: Sidney (choleric), Drake (melancholic), Glacia (phlegmatic), and Phoebe (sanguine).
** Sinnoh: Flint (choleric), and Lucien (melancholic), Bertha (phlegmatic), and Aaron (sanguine).
** Unova: Marshal (choleric), Caitlin (melancholic), Grimsley (phlegmatic), and Shauntal (sanguine).
** Kalos: Wikstrom (choleric), Siebold (melancholic), Drasna (phlegmatic) and Malva (sanguine).
** As well as the various Pokemon League Champions: Blue & Lance (choleric), Cynthia & Red (melancholic), Steven & Wallace (phlegmatic), and Alder, Iris & Diantha (sanguine).
* And the other characters as well:
** The main characters in Black and White: N (choleric), Cheren (melancholic), Hilbert/Hilda (phlegmatic), and Bianca (sanguine).
** The FiveManBand in X and Y: Calem/Serena (choleric), Trevor (melancholic), Tierno (phlegmatic), Shauna (sanguine), and the player (leukine).
** Kalos Battle Maison: Dana (choleric), Morgan (melancholic), Evelyn (phlegmatic), Nita (sanguine).
** The main villains of each team: Ghetsis and Lysandre (choleric), Giovanni and Cyrus (melancholic), Archie (sanguine), Maxie (phlegmatic).
** The rivals: Blue and Hugh (choleric), Silver and Cheren (melancholic), May and Brendan (phlegmatic), Barry and Bianca (sanguine).
* ''VideoGame/PokerNightAtTheInventory'' uses this to balance the table dynamic: [[VideoGame/SamAndMaxFreelancePolice Max]] (sanguine), [[WebAnimation/HomestarRunner Strong Bad]] (choleric), [[VideoGame/TeamFortress2 Heavy]] (melancholic), and [[Webcomic/PennyArcade Tycho]] (phlegmatic).
** ''VideoGame/PokerNight2'': [[WesternAnimation/TheVentureBrothers Brock Samson]] (choleric-melancholic), [[VideoGame/{{Borderlands}} Claptrap]] (sanguine), [[Franchise/EvilDead Ash Williams]] (sanguine-choleric), VideoGame/{{Sam|AndMaxFreelancePolice}} (melancholic-phlegmatic)
* ''VideoGame/{{Psychonauts}}'': Whispering Rock Psychic Summer Camp staff - Milla Vodello (sanguine), Morceau Oleander (choleric), Sasha Nein (melancholic), Ford Cruller (phlegmatic)
* The crew in ''VideoGame/SaintsRow2'' match up with this ''perfectly'':
** Sanguine and choleric: Johnny Gat - he's happy when he's killing people or going to kill people.
** Choleric and melancholic: The Boss, ''very much'' so, regardless of the voice you use - tends to explode when questioned or fucked with.
** Melancholic and phlegmatic: Pierce - humour involving him tends to make fun of his elaborate plans and high professional standards clashing with the extreme personalities of the rest of the group.
** Phlegmatic and sanguine: Shaundi '''by far''', what with being an archetypical laidback stoner.
** Carlos is a mild leukine.
* While in ''VideoGame/SaintsRowTheThird'', the group shift in some unusual ways:
** Shaundi shifts radically from leukine to choleric, running on pure anger from start to finish.
** Newcomer Oleg has some strong phlegmatic and leukine elements, but is mostly melancholic, becoming the key planner and thinker of the group.
** The Boss is left, oddly enough, as the phlegmatic one; unlike in ''Saints Row 2'', The Boss spends much more of the game haplessly reacting to the wild fortunes of fate thrown around him or her.
** Pierce has become significantly more sanguine, a happy-go-lucky gladhander.
* ''VideoGame/ShadowrunReturns'': Dragonfall has this among your team members:
** [[PlayfulHacker Blitz]] (Sanguine)
** [[BloodKnight Dietrich]] (Choleric)
** [[ColdSniper Eiger]] (Melancholic)
** [[TheStoic Glory]] (Phlegmatic).
* ''Franchise/SilentHill'''s first heroes: [[PluckyGirl Heather]] (choleric), [[ByronicHero James]] (melancholic), [[TheStoic Henry]] (phlegmatic), and [[PapaWolf Harry]] (sanguine).
* The main characters of ''Franchise/SlyCooper''
** [[GentlemanThief Sly Cooper]] (phlegmatic), [[GadgeteerGenius Bentley]] (melancholic), [[LargeHam THE MURRAY]] (sanguine), and [[InspectorJavert Carmelita Fox]] (choleric).
* ''Franchise/SonicTheHedgehog'':
** The main four heroes: [[SmugSuper Sonic]] (choleric/sanguine), [[ChildProdigy Tails]] (phlegmatic/melancholic), [[HotBlooded Knuckles]] (melancholic/choleric), [[TheHeart Amy]] (sanguine/phlegmatic)
** The Deadly Six: Zavok (choleric/melancholic), Zazz (sanguine), Zomnom (phlegmatic), Zeena (choleric), Zor (melancholic), and Master Zik (leukine).
* ''VideoGame/StarFox'':
** Team Star Fox: Fox (sanguine/choleric), Falco (choleric), Slippy (melancholic), Peppy (phlegmatic), Krystal (sanguine).
** Team Star Wolf: Wolf (choleric), Leon (sanguine), Panther (melancholic), Andrew (phlegmatic).
* ''VideoGame/StarWarsRepublicCommando'': The four Clone Commandos of Delta Squad are this. Delta-38, "Boss", is choleric, showing good leadership instincts. Delta-07, "Sev", is melancholic, being the ColdSniper of the group and showing great care to place each round for maximum effenciency. Delta-40, "Fixer", is phlegmatic, being, as Taun We put it, "A pure and uncomplicated soldier." Delta-62, "Scorch", is sanguine, showing much enjoyment in blowing the CIS forces apart.
* In ''VideoGame/StreetFighterII'', the four members of Shadaloo: Balrog (choleric), Sagat (phlegmatic), M. Bison (melancholic), and Vega (sanguine).
** The Four Apprentices of Master Goutetsu: Gouken (melancholic), Akuma (very choleric), Ryu (phlegmatic), Ken (sanguine).
* ''SuikodenIII'' has three groups. The main characters: [[LadyOfWar Chris]] (choleric), [[NonActionGuy Thomas]] (melancholic), [[ShellShockedVeteran Geddoe]] (phlegmatic), and [[WarriorPrince Hugo]] (sanguine). Duke's group: [[UnknownRival Duke]] (choleric), [[ParentalSubstitute Nicholas]] (melancholic), [[EyePatchOfPower Gau]] (phlegmatic), and [[MsFanservice Elaine]] (sanguine). Luc's group: [[BigBad Luc]] (melancholic), [[DarkMagicalGirl Sara]] (phlegmatic), [[PsychoForHire Yuber]] (sanguine), and [[MagnificentBastard Albert]] (leukine).
* The ''SuperMarioBros'' heroes: Mario (Choleric/Sanguine), Luigi (melancholic), Yoshi & Daisy (sanguine), Peach (leukine) Toad (choleric) and Rosalina (phlegmatic)
** The Koopalings and Bowsers: Bowser, Larry and Wendy (choleric), Roy (phlegmatic), Lemmy and Iggy (sanguine), Ludwig and Bowser Jr. (melancholic), and Morton (leukine).
* The five party members in ''VideoGame/SuperMarioRPG'': Mario (sanguine), Mallow (melancholic), Geno (leukine), Bowser (choleric) and Princess Toadstool (phlegmatic).
* The major ''PaperMario'' antagonists: Bowser (choleric), Sir Grodus (melancholic), [[spoiler: Shadow Queen]] (phlegmatic), Count Bleck (sanguine).
* Count Bleck's FiveBadBand in ''VideoGame/SuperPaperMario'': O'Chunks (choleric), Nastasia (melancholic), Mimi (phlegmatic, but with a good dose of AxCrazy), Dimentio (sanguine), and Count Bleck (leukine).
* The ATX Team in ''VideoGame/SuperRobotWars''. At first the lineup is Sanger (choleric), Bullet (melancholic), Kyosuke (phlegmatic), and Excellen (sanguine). Later, Kusuha was drafted into the team as the leukine. Later on, Sanger leaves, and Kyosuke takes on the choleric mantle; and when Lamia enters, she takes on the phlegmatic mantle.
* ''VideoGame/SuperSmashBros Melee''(Going by Canon personalities):
** Choleric: Falco, Ness, Bowser, Captain Falcon
** Choleric and melancholic: Mewtwo
** Melancholic: Ganondorf
** Phlegmatic: Luigi, Marth
** Phlegmatic and sanguine: Kirby, Yoshi, Jigglypuff, Pichu
** Sanguine: Mario, Donkey Kong, Pikachu, Fox
** Leukine: Peach, Link, Young Link, Samus, Zelda, [[FlatCharacter Game and Watch]], Roy
* ''VideoGame/SuperSmashBros Brawl'':
** Choleric: Mario, Falco, Ness, Bowser, Ike, King Dedede, Wario, Captain Falcon
** Choleric and melancholic: Wolf, Snake, Ivysaur
** Melancholic: Meta Knight, Ganondorf, Lucas, Lucario
** Phlegmatic: Luigi, Marth, Squirtle
** Phlegmatic and sanguine: Peach, Pit, Kirby, Yoshi, Jigglypuff, Toon Link
** Sanguine: Donkey Kong, Pikachu, Fox, Sonic, Charizard
** Leukine: Zelda/Sheik, Link, Diddy Kong, Samus, [[FlatCharacter Game and Watch]], R.O.B., Pokemon Trainer
* ''[[VideoGame/{{TCT RPG}} The Colour Tuesday]]'': Alex is the hotheaded driver of the story (choleric). Kyle is the determined and selfless (melancholic). Bella is a slightly airy {{Cloudcuckoolander}} (sanguine). Chadd, the last permanent cast member, is a born follower (phlegmatic).
* The ''VideoGame/TeamFortress2'' classes can be seen throughout the spectrum: Scout (choleric), Soldier (sanguine-choleric), Pyro (sanguine), Demoman (choleric-melancholic), Heavy (leukine, leaning choleric), Engineer (phlegmatic), Medic (phlegmatic-sanguine), Sniper (melancholic), Spy (melancholic-phlegmatic)
* The four main personality types in ''VideoGame/TomodachiLife'': Outgoing (sanguine), Confident (choleric), Independent (melancholic), and Easygoing (phlegmatic).
* The five playable characters in ''VideoGame/{{Touhou}}'' fit this better than a FiveManBand:
** Sanguine: Marisa is always boisterous and outgoing.
** Melancholic: Sakuya always seems to have [[UndyingLoyalty something on]] [[BodyguardCrush her mind]].
** Choleric: Sanae [[Memes/{{Touhou}} can't let herself be held back by common sense!]]
** Phlegmatic: Youmu, even at her angriest, always seems to [[ASpaceMarineIsYou stay frosty]].
** Leukine: Reimu falls somewhere in the middle. Exactly where [[DependingOnTheWriter Depends on the Writer]], but in {{Canon}} she's pretty solidly in the middle overall.
* The Group from ''VideoGame/TheLegendOfZeldaTwilightPrincess'' exhibits this: Auru (choleric), Shad (melancholic), Ashei (phlegmatic), Telma (sanguine) and Link (leukine).
* ''{{Tsukihime}}'' has Akiha (choleric), Ciel/Kohaku (sanguine facade but actually melancholic), Hisui (phlegmatic), and Shiki/Arcuied (sanguine).
* ''VideoGame/TransformersFallOfCybertron'' The Multiplayer classes (playing style): Titan (choleric), Destroyer (melancholic), Infiltrator (sanguine or phlegmatic), Scientist (phlegmatic).
* ''VisualNovel/VirtuesLastReward'': Dio and Tenmyouji (choleric), Alice and K (melancholic), Phi and Quark (phlegmatic), Sigma and Clover (sanguine), and Luna (leukine).
* {{Xenogears}} has the Neo-Elements: Seraphita (sanguine), Tolone (choleric), Dominia (melancholic), Kelvena (phlegmatic).
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