A very long-running comic strip created in 1954 by Brad Anderson. Originally, Anderson was intially aided by Phil Leeming and later Dorothy Leeming, but he came to maintain the strip solo for many years. Eventually, he also enlisted his son Paul Anderson to help (2004 onward).

Marmaduke is a monstrous Great Dane - the comic regularly shows him at least 40 inches at the withers; the largest Great Dane was 44 inches. He's owned by Phil and Dottie Winslow, a stereotypical fifties husband and wife, and their kids, Barbara and Billy. Most of the "jokes" center on Marmaduke being big, messy, and/or thinking he's human. The strip seems to exist mainly as the target of SnarkBait, mainly on the repetitive nature that the strip seems to be locked in.

Incredibly, a live action/CGI ''Film/{{Marmaduke}}'' movie was released in June 2010, with Owen Wilson voicing the title character.

Brad Anderson passed away in August 2015, leaving the future of the strip in Paul's hands.

!!Tropes present:

* AnimatedAdaptation: The 1980 ''ComicStrip/{{Heathcliff}}'' TV series (the Creator/RubySpears version, not the ''WesternAnimation/HeathcliffAndTheCatillacCats'' version) featured animated ''Marmaduke'' segments as well.
* BigFriendlyDog: Marmaduke.
* CanisMajor: Guess who?
* {{Crossover}}: Marmaduke appeared at the beginning of a [[http://www.garfield.com/comics/vault.html?yr=1991&addr=910331 Sunday]] ''ComicStrip/{{Garfield}}'' strip. As Garfield realized the fence he was painting his name on was Marmaduke's, he apologized stating [[BreakingTheFourthWall "wrong strip"]].
* DogWalksYou: A regularly recurring gag.
* LiveActionAdaptation
* PrintLongRunners: 50+ years.
* SquareCubeLaw: Bent over and thoroughly violated. [[MemeticMolester Much like owner-man]].
* SuddenlyVoiced: In TheMovie.