The Twist is that the disease is not actually a proper disease, but something else with symptoms of a disease
As a reveal trope, spoilers
The Grey Death of Deus Ex is in fact nanomachines, with the symptoms caused by immune system rejection. The player character is genetically engineered to accept them and is immune as a result
The "Corprus" in Morrowind is Dagoth Ur's divine will changing the effected creature.
Five hats means that five tropers think it is ready to publish.
You are saying that you think this draft is ready to be published. That means the description is not ambiguous,
it doesn't duplicate an existing trope, there are at least three examples, and the title makes sense.
Is that what you meant to do?
You are saying this draft has a ready-to-publish hat it does not deserve and you are taking it back.