History YMMV / OzzyAndDrix

* AdaptationDisplacement: Downplayed. While the original ''Osmosis Jones'' film is a CultClassic, it was also a BoxOfficeBomb due to Warner Bros. ExecutiveMeddling that resulted in an unfocused film. As a result, there are some fans of this show that aren't aware that it's supposed to be a spin-off until much later.

* AccidentalAesop: "Dream Factory" doesn't have a clear Aesop about health like most others, but it could be read as the show's SleepAesop since Hector's lack of sleep does almost get him killed (his lack of focus almost gets him run over in one scene). The difference being that, unlike most Aesop episodes, the lack of sleep isn't Hector's fault (it's from a reoccuring nightmare as opposed to, for instance, him staying up late playing video games or having to pull all-nighters to complete schoolwork he procrastinated on).

* FridgeBrilliance: There's actually a biological explanation for how ThePowerOfLove allowed Hector to refuse the second cigarette in "Where There's Smoke". Crushes produce dopamine and serotonin because of the positive feelings associated with the object of your affection so Hector was able to override the pleasure Nick promised with the positivity Christine represented.

* JerkassWoobie: Ozzy's evil twin in the episode where Ozzy undergoes mitosis and splits into two. While his motives don't justify trying to kill Ozzy, he notes that his [[MultiArmedAndDangerous mutation]] will lead to him being rejected by Hector unless he kills the original, meaning he's basically motivated by a fear of dying so soon after he came into existence. Even ''Ozzy himself'' seems to sympathize, as he arranges to have his twin sent to Hector's dog to be "King of the Canine" rather than just straight up flushed.

* AuthorsSavingThrow: One of the most common criticisms of the movie was the live-action portions due to them not gelling well with the animated portions as well as the overuse of gross-out humor. This series is entirely animated, it creates a closer connection between the inside body scenes and the outside body scenes, and the gross-out humor is downplayed and uses other humor such as [[DeadpanSnarker snarky]] humor.

* {{Fanon}}: "Double Dose" is kicked off by Ozzy dividing in two during a nightmare, specifically one recreating the Bugs Bunny Cartoon WesternAnimation/HareRaisingHare. However, the shot we get of him reacting to it -- writhing fitfully in bed, punching the pillow in his sleep, and then splitting in two -- has led to the fandom to speculate that it actually happened during a different nightmare, one where he was reliving his battle with Thrax.

* {{Fanon}}: "Double Dose" is kicked off by Ozzy dividing in two during a nightmare, and from what we're shown of said nightmare, it's very goofy. However, the shot we get of him reacting to it -- writhing fitfully in bed, punching the pillow in his sleep, and then splitting in two -- has led to the fandom to speculate that it actually happened during a different nightmare, one where he was reliving his battle with Thrax.

* TheyWastedAPerfectlyGoodPlot:
** Allergies are biologically described, as what happens when the white blood cells become overprotective towards a specific thing (allergens). Knowing this fact, the episode with allergens could've been the perfect opportunity to make fun of the way governments [[PoliceBrutality (and cops)]] go to ridiculous lengths in fighting crime and terror. Instead, the allergen is just as antagonistic as every other germ in the series and the closest we get is an innocent being mistaken for the allergen.
** The fact that Hector was a relatively normal boy left a lot of unanswered questions as to how the body and mind, and their respective characters, would be different if the host had a chronic condition or mental disorder. Doubly jarring since Ozzy ''did'' travel to Christine's body at one point, where we saw how the lifestyles of those inside bodies differed depending on the biological sex of their host, meaning examining other bodies while still having Hector as the main hub would have been possible. And of course, it being for younger audiences, the onset of sexual maturity and [[{{Squick}} everything it entails]] wasn't explored (though Hector does experience a small growth spurt and some G-rated side effects of puberty).

* HilariousInHindsight: During the ColdOpening of "Gas of Doom" the band leader Ozzy saves calls him a "VideoGame/GuitarHero". The first game wouldn't be out for another 3 years when this episode aired.

* {{Fanon}}: "Double Dose" is kicked off by Ozzy dividing in two during a nightmare, and from what we're shown of said nightmare, it's very goofy. However, the shot we get of him reacting to it -- writhing fitfully in bed, punching the pillow in his sleep, and then splitting in two -- has led to the fandom to speculate that it happened during a different nightmare, one where he was reliving his battle with Thrax.

* SugarWiki/AwesomeMusic: The theme song ''definitely'' qualifies.

* BrokenBase: Whether the show is a sequel to the film or some sort of alternate universe. In the first episode, Frank is shown living in a trailer instead of a house and his daughter Shane is nowhere to be seen.
* SugarWiki/AwesomeMusic: The theme song ''definitely'' qualifies.
* BrokenBase: Some fans see the series as better than the movie due to the omission of live-action grossout scenes and its edutainment factor, while others see it as inferior to the movie and expressed disappointment that the darker, "adult" tone of the movie was replaced with a lighter, cheesier, more kid-friendly one in the show.

* TheScrappy: Mayor Spryman. He's a BrattyHalfPint UngratefulBastard who abuses his power as mayor and bullies Ozzy.

* FandomSpecificPlot: It's a little niche but there are more than a few fans who love the idea of Ozzy and Drix co-parenting Spryman and trying (mostly successfully) to unspoil him. Content generally features Ozzy and Drix being GoodParents and Spryman (referred to as either just Paul or [[AffectionateNickname Paulie]]) eventually coming to appreciate them as parental figures.

** Some fans actually view Spryman this way; ''yes'' he's a BrattyHalfPint UngratefulBastard SpoiledBrat but we never see his parents so it's entirely possible he was or at least is currently being raised by a bunch of YesMan politicians who give whatever he wants to shut him up so they don't have to deal with him and his bratty behavior is the result of being a teenager without any proper adult guidance. Contrast him with Hector, the teen whose body he's in charge of, who is a much more likeable kid and it's clearly due to his GoodParents.
* TheProblemWithLicensedGames: The ''only'' impressive thing that could be said about the UsefulNotes/GameBoyAdvance game is that it managed to use real-time rendered 3D models for all the characters throughout the game. Everything else is a complete and utter snore fest, lacking any variety between Osmosis and Drix, bland, repetitive music, and loads and load of FakeDifficulty caused by stiff controls that may not even register your inputs half of the time.

* AuthorsSavingThrow: One of the most common criticisms of the movie was the live-action portions due to them not gelling well with the animated portions as well as the overuse of gross-out humor. This series is entirely animated, it creates a more closer connection between the inside body scenes and the outside body scenes, and the gross-out humor is downplayed and uses other humor such as [[DeadpanSnarker snarky]] humor.

* NightmareFuel: The smoking episode.
** All of "Lights Out" the fact that they play the idea of a concussion very seriously, the very idea that if Ozzy and Drix didn’t jumpstart Hector's brain? He would’ve died.

* HilariousInHindsight: One episode has a LawyerFriendlyCameo of [[Franchise/{{Pokemon}} Pikachu]]. About six years after the show came out, scientists discovered an extracellular protein they called ''pikachurin''.

* TheScrappy: Mayor Spryman. He's an UngratefulBastard who abuses his power as mayor and bullies Ozzy.

* EvilIsCool: Nick O'Teen has a badass design, is a genuinely menacing villain, is voiced by Creator/TimCurry, and sings a VillainSong backed by {{Captain Erzatz}}es of Music/{{Metallica}}. What's not to love?

* StrawmanHasAPoint: Both Chief Gluteus and Mayor Spryman tend to give Ozzy, and to a lesser extent Drix, a hard time when it comes to their involvement in trying to take down the germs and viruses that want to harm Hector, as they both don't get much respect or gratitude for the rounds up they make, and have been blamed a couple of times for things that weren't their fault. But considering that Ozzy tends to cause trouble for both Gluteus and Spryman a lot, he is often disrespectful to both of them especially when he met them in the first episode, and since he and Drix are both detectives and their involvement in police work comes off as vigilantism, it's justified why he and Drix don't get much respect from them.