History YMMV / OsmosisJones

** It also has one with ''Film/KangarooJack'' and ''Film/ScoobyDoo2002'' for being WB films that were retooled from adult oriented films to family friendly ones.

* MoralEventHorizon: Thrax crosses it by murdering two cells in his introduction with his touch. If that's not enough, he reveals a collection of DNA from past victims. One of them was [[WouldHurtAChild a little girl who didn't want to wash her hands.]] Another was a nice lady and yet another was [[WouldHarmASenior an elderly man]]. He even expresses a desire to kill Frank's daughter to break the record he'll set by killing Frank.

* IdiotPlot: The entire plot could’ve been avoided, had Frank not been dumb enough to eat an egg that was previously in a chimp’s mouth and in the dirt.

* MoralEventHorizon: Thrax crosses it by murdering two cells in his introduction with his touch. If that's not enough, he reveals a collection of DNA from past victims. One of them was [[WouldHurtAChild a little girl who didn't want to wash her hands.]] Another was a nice lady and yet another was an elderly man. He even expresses a desire to kill Frank's daughter to break the record he'll set by killing Frank.

** You can't fuck Osmosis Jones. [[labelnote:Explanation]]A Tumblr user of the same name made a post explaining why it would be impossible to have sex with Osmosis Jones due to his microscopic size. [[https://youtube.com/watch?v=ipf9MBuurv4 Other users replied]] with suggestions on how it would actually be possible if one tried hard enough. This conversation is often brought up whenever Osmosis Jones is mentioned on Tumblr.[[/labelnote]]

* HarsherInHindsight:
** The movie building up Osmosis and Leah as a couple goes down the drain when you put the spin-off show into account where Osmosis and Drix are forced out of Frank and transferred to a different body.
** Thrax’s meticulous actions throughout the film, making it seem like Frank only has a common cold until it’s too late, has become a lot more terrifying thanks to 2020’s UsefulNotes/COVID19Pandemic.

** You can't fuck Osmosis Jones. [[labelnote:Explanation]]A Tumblr user of the same name made a post explaining why it would be impossible to have sex with Osmosis Jones due to his microscopic size.[[https://youtube.com/watch?v=ipf9MBuurv4 Other users replied]] with suggestions on how it would actually be possible if one tried hard enough. This conversation is often brought up whenever Osmosis Jones is mentioned on Tumblr.[[/labelnote]]

** You can't fuck Osmosis Jones. [[labelnote:Explanation]]A Tumblr user of the same name made a post explaining why it would be impossible to have sex with Osmosis Jones due to his small size. [[https://youtube.com/watch?v=ipf9MBuurv4 Other users replied]] with suggestions on how it would actually be possible if one tried hard enough. This conversation is often brought up whenever Osmosis Jones is mentioned on Tumblr.[[/labelnote]]

** You can't fuck Osmosis Jones. [[labelnote:Explanation]]A Tumblr user of the same name made a post explaining why it would be impossible to have sex with Osmosis Jones due to his small size. [[https://youtube.com/watch?v=ipf9MBuurv4 Other users replied]] with suggestions on how it would actually be possible if one tried hard enough. This conversation is often brought up whenever Osmosis Jones is mentioned on Tumblr.[[/labenote]]

* SignatureScene:
** Frank eating the egg as it switches to the first animated portion of the movie taking place in Frank's mouth, as it was one of the scenes most prominently showcased in promotional material for the movie. This is in addition to how memorably disgusting the scene is, said egg having been previously ''in a chimpanzee's mouth'' and then ''on the ground of the chimp cage''.

** Frank picks up a hard-boiled egg and eats it. What makes this Squick? The egg has been on the ground in a filthy chimpanzee cage, and before that it was IN THE CHIMP'S MOUTH. Maybe all his unhealthy habits were affecting his brain?

* TheyWastedAPerfectlyGoodPlot: Many enjoy the inside-body animated story and feel that the movie would be better if the poorly-received gross-out live-action scenes were thrown out.

** With ''Manga/CellsAtWork'', thanks to its similar premise.

** [[{{Franchise/Pokemon}} Pikachu]] makes a small cameo, being held by a germ. Pikachurrin, a protein, wouldn't be discovered until 2008.

** Creator/WillSmith was going to voice Ozzy before he turned down due to his schedule. He would later voice in another kids' crime movie ''WesternAnimation/SharkTale'' and play the blue Genie from ''Film/Aladdin2019''.

* LauncherOfAThousandShips: [[EvilIsSexy Thrax]]. Fans tend to ship him with either [[FoeYay Ozzy]], a SelfInsert, or an OriginalCharacter. And many a {{Fanvid}} maker has made fan edit {{Crossover Ship}}s of him with just about any 2D [=Non/Disney=] animated film character you can think of, the most popular choices being [[WesternAnimation/TheSwanPrincess Odette]] and [[WesternAnimation/SinbadLegendOfTheSevenSeas Eris]].

* Thrax falling into the container of rubbing alcohol and being utterly obliterated is an extremely crowd-pleasing moment.

* CatharsisFactor: Whether you feel bad for her or not, it is truly satisfying to see Shane get off her school bus to follow the ambulance carrying her dad and disobeying her insufferable and unforgiving teacher Miss Boyd, who has spent the whole movie being a total bitch to Frank.

* NauseaFuel: [[NauseaFuel/OsmosisJones Enough to the deserve its own page]].
* OneSceneWonder: Creator/RonHoward as Tom Colonic, thanks to his caring attitude as a politician.

* RealismInducedHorror: Thanks to outbreaks such as [=SARS=], [=H1N1=] and [=COVID-19=], Thrax is naturally taken as seriously as a threat.

* VindicatedByHistory: Even though it got bad reviews when it came out, it gained a loyal following among the nostalgia crowd and for its accurate depiction of the human body.

** It also has one with ''Film/KangarooJack'' and ''Film/ScoobyDoo'' for being WB films that were retooled from adult oriented films to family friendly ones.

* CatharsisFactor: Whether you feel bad for her or not, it is truly satisfying to see Shane get off her school bus to to follow the ambulance carrying her dad and disobeying her insufferable and unforgiving teacher Miss Boyd, who has spent the whole movie being a total bitch to Frank.

** This film stars Creator/ChrisRock playing a [[IWorkAlone lone wolf]] cop who’s treated like a pariah by fellow officers for doing the right thing (with bad results) in the past, and is on the trail of a mysterious killer. 20 years later, he’d be playing a very similar role in ''Film/Spiral2021''.

** Thrax’s meticulous actions throughout the film, making it seem like Frank only has a common cold until it’s too late, has become a lot more terrifying thanks to 2020’s the UsefulNotes/COVID19Pandemic.

** "''Osmosis Jones'' tried to warn us!" [[labelnote:Explanation]]Frank’s carelessness leading to getting infected with an unknown and nearly lethal virus, and Thrax’s actions throughout the film (making it seem like Frank only has a common cold until it’s too late), has hit a lot closer to home since the UsefulNotes/COVID19Pandemic started in 2020.[[/labelnote]]

* HarsherInHindsight: The movie building up Osmosis and Leah as a couple goes down the drain when you put the spin-off show into account where Osmosis and Drix are forced out of Frank and transferred to a different body.

* MemeticMutation: Thrax escaping the [[BlackBugRoom Subconscious Room]] is used to represent a ScrewThisImOuttaHere reaction.

** "''Osmosis Jones'' tried to warn us!" [[labelnote:Explanation]]Frank’s carelessness leading to getting infected with an unknown and nearly lethal virus, and Thrax’s actions throughout the film (making it seem like Frank only has a common cold until it’s too late), has hit a lot closer to home since 2020’s UsefulNotes/COVID19Pandemic started.[[/labelnote]]