History ShoutOut / TheBindingOfIsaac

* The Wire Hanger item is a reference to the film ''Film/MommieDearest'', in which an abusive mother screeches the famous quote: "No more wire hangers ever!"

*** The boss Chub can be beaten by feeding her bombs, like Dodongo.

* The Wrath boss is basically VideoGame/{{Bomberman}}.
** In addition, players will occasionally find a room styled after the mazes from Bomberman's multiplayer filled with bombs to collect.

* The Necronomicon's cover (which looks like a distorted or disfigured face) is the same as in Franchise/EvilDead.

* The Chemical Peel item will give you a [[Franchise/{{Batman}} Harvey Dent]] makeover.

** One of the endings: [[spoiler:Isaac dresses as Dr. Fetus from ''SuperMeatBoy'', complete with the stage title theme from that game. Unsurprisingly, the ending gives you the Fetus in a Jar powerup.]] There's also a power-up called "Doctor's Remote," which is another reference to the character in question.

* The Wire Hanger item is a reference to the film ''Film/MommieDearest'', in which an abusive mother screeches the famous quote: "No more wire hangers ever!"

* One weapon upgrade is [[{{Ashens}} Sad Onion]].

* One of the messages the purple slot machines will give you is "Look to la Luna!" which was one of the hints Reptile gives you regarding the secret fight against him in the original MortalKombat.

* One of the messages the purple slot machines will give you is "Look to la Luna!" which was one of the hints Reptile gives you regarding the secret fight against him in the original MortalKombat.

* One of the messages the purple slot machines will give you is "Look into la Luna!" which was one of the hints Reptile gives you regarding the secret fight against him in the original MortalKombat.

* '''Subverted''' in the case of Gluttony. A lot of fans think that his appearance and the blood-laser that shoots from the stomach are references to ''Manga/FullmetalAlchemist''; HOWEVER, [[WordOfGod Edmund McMillen]] himself has stated several times that the resemblance is purely coincidental, because he has never watched (nor even heard of, prior to the game's release) ''Fullmetal Alchemist''. Holy [[IdenticalStranger contrived coincidences]], Batman!

** In addition, players will occasionally find a room filled with collectable bombs styled after the mazes from Bomberman's multiplayer.

* '''Subverted''' in the case of Gluttony. A lot of fans think that his appearance and the blood-laser that shoots from the stomach are references to ''FullmetalAlchemist''; HOWEVER, [[WordOfGod Edmund McMillen]] himself has stated several times that the resemblance is purely coincidental, because he has never watched (nor even heard of, prior to the game's release) ''Fullmetal Alchemist''. Holy [[IdenticalStranger contrived coincidences]], Batman!

** The Stepladder from the original Zelda's functionality identical counter-part, simply called "The Ladder."

* A number of internet meme faces make an appearance, particularly the [[http://knowyourmeme.com/memes/forever-alone Forever Alone]] and [[http://knowyourmeme.com/memes/trollface-coolface-problem Troll Face]], with the latter appearing on bombs which are ready to go off. And let's not forget [[http://knowyourmeme.com/memes/shoop-da-whoop-i%E2%80%99m-a%E2%80%99-firin%E2%80%99-mah-lazer Shoop-Da-Woop!]], which is a charged lazer weapon. There is also an enemy type with a distinctive trollface that will split in half upon receiving enough damage, and the duplicates will split further into even smaller copies, demonstrating the spirit, as well as appearance of the {{troll}}face. In its smallest form it becomes a [[http://knowyourmeme.com/memes/poker-face Pokerface]].

* One of the messages you can get from the Fortune Teller is "Look to La Luna." This was the clue on how to find Reptile in the original ''VideoGame/MortalKombat'' game. Two others, "MARRY AND REPRODUCE" and "STAY ASLEEP" reference ''Film/TheyLive''.

** The 1-up mushroom that follows you around is green with white spots]].

* '''Subverted''' in the case of Gluttony. A lot of fans think that his appearance and the blood-laser that shoots from the stomach are references to ''FullmetalAlchemist''; HOWEVER, [[WordOfGod Edmund McMillen]] himself has stated several times that the resemblance is purely coincidental, because he has never wayched (nor even heard of, prior to the game's release) ''Fullmetal Alchemist''. Holy [[IdenticalStranger contrived coincidences]], Batman!

* FullmetalAlchemist: One of Gluttony's attacks involves him opening his stomach, and releasing a beam.

* An item named "Telepathy for Dummies," looking exactly like any "for Dummies" book would look like.

* A number of internet meme faces make an appearance, particularly the Forever Alone and Troll faces, with the latter appearing on bombs which are ready to go off. And let's not forget Shoop-Da-Woop!, which charges ya laser. There is also an enemy type with a distinctive trollface that will split in half upon gaining enough damage, and the duplicates will split further into even smaller copies, demonstrating the spirit, as well as appearance of the trollface. In its smallest form it becomes a pokerface.

** One of the best activated items (recharges per time, burns projectiles, does high damage) is The (Blue) Candle.

** Some enemies are also reminiscent of Zelda enemies. The most noticeable are the Chargers (which behave like Ropes) and Knights (which behave like Darknuts).
*** The boss Chub can be beaten by feeding him bombs, like Dodongo.

* When going into the OneWingedAngel form accessible through one of Eve's starting items, the transformation is denoted by the phrase [[VideoGame/CastlevaniaIISimonsQuest "What a horrible night to have a curse."]]

* One of the messages you can get from the Fortune Teller is "Look to La Luna." This was the clue on how to find Reptile in the original ''VideoGame/MortalKombat'' game. Two others, "MARRY AND REPRODUCE" and "STAY ASLEEP" reference ''Film/TheyLive''.

** For some reason, TheStinger of the final ending tells you to [[spoiler:get in the box.]]

* One of the messages you can get from the Fortune Teller is "Look to La Luna." This was the clue on how to find Reptile in the original ''VideoGame/MortalKombat'' game. Two others, "MARRY AND REPRODUCE" and "STAY ASLEEP" reference ''Film/TheyLive''.