History RoguesGalleryTransplant / MarvelUniverse

** Comicbook/TheFlash expy the Whizzer gains the Silver Witch (a version of Characters/ScarletWitch who absorbed the speed of her brother Comicbook/{{Quicksilver}}) as his nemesis, and also fights Ursa Major (here a stand-in for Gorilla Grodd).

** Comicbook/{{Superman}} expy Hyperion gains Characters/DoctorDoom, the Hulk, the Beyonder and Comicbook/{{Ultron}}, with most of them positioned as pastiches of traditional Superman rogues (the Hulk as Comicbook/{{Bizarro}}, Mr. Beyonder as Mr. Mxyzptlk and Ultron as Metallo).

** Comicbook/GreenLantern expy Doctor Spectrum gains a bunch of cosmic villains like Thanos, Ego the Living Planet, the Super-Skrull, Ronan the Accuser, and despite not being cosmic-themed, the Circus of Crime. Uatu the Watcher also serves as another of his adversaries despite mostly being a good guy in the mainline universe.

** Comicbook/WonderWoman expy Warrior Woman gains traditional Thor baddies Mangog, Gorr the God Butcher, Ulik and Hela, as well as traditional Avengers [[Comicbook/TheWasp Janet Van Dyne]], Tigra and [[Comicbook/TheIncredibleHercules Hercules]] (serving as pastiches of Wonder Woman's foes Giganta, Comicbook/{{Cheetah}} and Hercules, respectively), traditional X-Men members [[Comicbook/JeanGrey Phoenix]] and Comicbook/IllyanaRasputin, and the Venom villain Knull.

** Comicbook/WonderWoman expy Warrior Woman gains traditional Thor baddies Mangog, Gorr the God Butcher, Ulik and Hela, as well as traditional Avengers [[Comicbook/TheWasp Janet Van Dyne]], Tigra and Hercules (serving as pastiches of Wonder Woman's foes Giganta, Comicbook/{{Cheetah}} and Hercules, respectively), traditional X-Men members [[Comicbook/JeanGrey Phoenix]] and Comicbook/IllyanaRasputin, and the Venom villain Knull.

* While ComicBook/{{Magneto}} is primarily known for his [[HeelFaceRevolvingDoor complicated]] relationship with the X-Men, he has tangled with all of Marvel's major heroes as well, particularly the Avengers, Fantastic Four, Thor, and Spider-Man. A key moment in his backstory, where he was deaged to infancy, actually occurred after a fight against ComicBook/TheDefenders.

** Comicbook/{{Superman}} expy Hyperion gains Comicbook/DoctorDoom, the Hulk, the Beyonder and Comicbook/{{Ultron}}, with most of them positioned as pastiches of traditional Superman rogues (the Hulk as Comicbook/{{Bizarro}}, Mr. Beyonder as Mr. Mxyzptlk and Ultron as Metallo).

* In his initial few appearances, Kang the Conqueror was a ComicBook/FantasticFour villain called Rama-Tut, with it even being implied that he was a future descendent of Doctor Doom. After taking on his far better known name and appearance as Kang, he primarily battled the Avengers, though he still shows up to menace the FF and other heroes from time to time.

* Graviton is primarily an Avengers villain, but was also a major recurring adversary of the original ComicBook/{{Thunderbolts}}. He’s also faced other heroes like ComicBook/{{Shuri|Marvel Comics}} and Miles Morales.

* Many of Marvel's 2019 annuals were themed under the banner ''Acts of Evil'', with no actual story throughline, but a theme of heroes fighting villains they would normally have nothing to do with, such as [[ComicBook/MsMarvel2014 Ms. Marvel]] versus the Super-Skrull, the Punisher versus the Brood and ComicBook/SheHulk versus ComicBook/{{Bullseye|Marvel Comics}}.

* The Super-Adaptoid was introduced as an enemy of Captain America, but very quickly moved on to fighting the X-Men and Avengers as well (fittingly, as [[AllYourPowersCombine it originally possessed the combined powers of the latter team at the time]]). Nowadays it's mostly considered an Avengers villain, though that hasn't stopped it from also mixing it up with the likes of Spider-Man and the Hulk on occasion.

* [[EldritchAbomination Shuma-Gorath]] was actually first mentioned in a Creator/RobertEHoward short story, but has been better known for his classic fights against ComicBook/DoctorStrange. He more or less lost his association with the good doctor when he [[UnexpectedCharacter unexpectedly appeared in]] ''VideoGame/MarvelSuperHeroes'', [[AdaptedOut where Strange was absent]]. Due to the Howard connection, Shuma also menaced ComicBook/ConanTheBarbarian in his Marvel series, as well as the ''Comicbook/SavageAvengers'' when Conan was part of that group. ''ComicBook/TheThanosImperative'' and a few other appearances helped him get upgraded to universal threat, like Mephisto or Thanos, and he later served as a StarterVillain for Comicbook/LukeCage's incarnation of the ''Comicbook/MightyAvengers''. Similarly, Nightmare started as a ComicBook/DoctorStrange foe, but has since then fought with pretty much everybody.

* In his initial few appearances, ComicBook/KangTheConqueror was a ComicBook/FantasticFour villain called Rama-Tut, with it even being implied that he was a future descendent of Doctor Doom. After taking on his far better known name and appearance as Kang, he primarily battled the Avengers, though he still shows up to menace the FF and other heroes from time to time.

* Speaking of [[ComicBook/SubMariner Namor]], while his Silver Age return pegged him as an enemy of the Fantastic Four and ComicBook/MisterFantastic's romantic rival, Stan Lee and Jack Kirby quickly established him as a threat to the wider Marvel Universe by having him also fight the Avengers and X-Men. His constant HeelFaceRevolvingDoor tendencies have led him to clash with a great many Marvel heroes over the years, including ComicBook/BlackPanther and the ComicBook/SquadronSupreme.

* [[EldritchAbomination Shuma-Gorath]] was actually first mentioned in a Creator/RobertEHoward short story, but has been better known for his classic fights against ComicBook/DoctorStrange. He more or less lost his association with the good doctor when he [[UnexpectedCharacter unexpectedly appeared in]] ''VideoGame/MarvelSuperHeroes'', [[AdaptedOut where Strange was absent]]. Due to the Howard connection, Shuma also menaced ComicBook/ConanTheBarbarian in his Marvel series. ''ComicBook/TheThanosImperative'' and a few other appearances helped him get upgraded to universal threat, like Mephisto or Thanos. Similarly, Nightmare started as a ComicBook/DoctorStrange foe, but has since then fought with pretty much everybody.

* Moses Magnum started out fighting Spider-Man and ComicBook/ThePunisher, but seems to have eventually settled on antagonizing ComicBook/BlackPanther. Thematically, Magnum and T'Challa are a perfect fit, and ''WesternAnimation/IronManArmoredAdventures'' chose to make Magnum [[YouKilledMyFather murder]] T'Chaka instead of Klaw.
* Klaw is a Black Panther villain, but he's also a fairly prominent enemy of the Fantastic Four (debuting in their comic, where Black Panther also debuted), and has menaced Daredevil a number of times as well. Generally, Klaw can be counted on to anatoginze anyone associated with his original foes, the FF and Black Panther through RevengeByProxy. He's menaced the Avengers a few times, even if Black Panther isn't in the line up and will go after the next available hero if his original target isn't around. After his first defeat and transformation into living energy, his first act is to travel to New York and get revenge on the FF for helping Black Panther.

* A temporary case - today, the Sandman is best-known as a Spider-Man villain, and he indeed made his first few appearances in ''The Amazing Spider-Man'', but during the '60s and '70s he ''mostly'' pestered the ComicBook/FantasticFour, either solo or as part of [[ThePsychoRangers the Frightful Four]]. In fact, the very first issue of ''Marvel Team-Up'' (a 1972 Christmas special) has Spidey claiming he only fought Sandman once, and the FF are the ''real'' "Sandman experts".

--> '''Young!Cyclops:''' Uh, what're you guys doing here?
--> '''Deadpool:''' Hi-ya, Mini-Cyclops! We got a present for you!
--> '''Spider-Man:''' We know he's not a mutant, but even though I fought him first he's somehow become part of the whole X-Men deal. Which makes him your deal.

->''"Who she could be is a nightmare list I don't even want to think about...but probably should. Star is an obvious choice. Moonstone. Minn-Erva. Deathbird. Mystique. All contenders. [[LampshadeHanging Though Mystique seems too preoccupied these days to come after me. Deathbird too]]."''
-->'''[[Characters/MarvelComicsCarolDanvers Carol Danvers/Captain Marvel]]''', ''ComicBook/{{Captain Marvel|KellyThompson}}'' vol. 10, issue 32 (Mystique and Deathbird have both gone on to become ComicBook/XMen villains)

* Since his resurrection Kraven the Hunter and his daughter Ana have been seen fighting other superheroes on a daily basis, mostly related to Spider-Man like ComicBook/{{Venom}}, [[ComicBook/SpiderWoman Spider-Girl]] or ComicBook/ScarletSpider, but ComicBook/BlackPanther and ComicBook/IncredibleHulk are also fair game. It helps Kraven seems to now live in the Savage Land, a place commonly visited by various superheroes.

** ZigZaggingTrope with Gremlin. Gremlin uses the name and the armor of the Titanium Man, an Iron Man foe who goes way back, but Gremlin himself is primarily a Hulk villain, first appearing in ''ComicBook/IncredibleHulk'' #163.

* ComicBook/{{Wolverine}} started out as a foe of the Hulk before becoming primarily associated with the Franchise/XMen.

* The Collector first showed up as an Avengers villain, but thanks to his habit of stealing rare artifacts and organisms, he's clashed with the likes of the ComicBook/SilverSurfer, ComicBook/{{Wolverine}}, the Hulk, and ComicBook/StarLord. The ''ComicBook/ContestOfChampions2015'' series also had him as a general threat who, alongside the Maestro, kidnapped a number of Marvel characters from across the Multiverse to force them to fight to the death.

** Killer Shrike likewise underwent this, going from a foe to the Hulk and Iron Man in the classic Marvel Universe, to a foe of Spider-Man in the ultimate Universe.

* The [[PsychoForHire contract killer]] Boomerang, who uses deadly gimmick boomerangs as his weapons, originally started out fighting [[ComicBook/IncredibleHulk the Hulk]], before he moved on to become a semi-regular Franchise/SpiderMan villain after writers realized that trick boomerangs versus the most powerful creature on Earth was a bit of a mismatch. Boomerang even appears in the Uncanny X-Men UsefulNotes/{{Nintendo|EntertainmentSystem}} game by LJN even though he's neither a X-Men enemy nor a mutant.
* Mister Hyde, a villain based on ''Literature/TheStrangeCaseOfDrJekyllAndMrHyde'', started out as a [[ComicBook/TheMightyThor Thor]] villain but would later move on to become a ComicBook/{{Daredevil}} regular, although he also took the time to mess with Franchise/SpiderMan, ComicBook/CaptainAmerica, ComicBook/GhostRider, and [[ComicBook/IncredibleHulk the Hulk]], finally settling in to become a regular foe of Cap, DD and the Big Green Machine. These days he seems to have moved to fighting teen heroes, considering his appearances in both ''ComicBook/YoungAvengers'' and ''ComicBook/AllNewGhostRider''. He was later revealed as the father of ComicBook/DaisyJohnson, and has been a foe of her as well.

* The first Moonstone was a Captain America villain, and the woman who would eventually steal his powers as the second Moonstone was initially an EvilMinion who was of little concern to Captain America. When she became a full fledge super villain she started off as a Hulk foe, but became more of a general Avengers villain after joining the Masters of Evil, forming a direct rivalry with the second [[ComicBook/MonicaRambeau Captain Marvel]]. Then she became a rival to Baron Zemo and the third Captain Marvel/second Photon, Genis-Vell during ''ComicBook/{{Thunderbolts}}''. Then during Comicbook/DarkReign, she was positioned as Ms. Marvel's EvilCounterpart in Norman Osborn's ComicBook/DarkAvengers. She continues to oppose ComicBook/CarolDanvers as she becomes Captain Marvel #6, though not always willingly.
* June Covington, aka "Toxic Doxie", started off as one of Norman Osborn's allies from his limited series. She went on to menace the ComicBook/NewAvengers as the ComicBook/DarkAvengers' impostor Scarlet Witch, but has since settled on terrorizing [[ComicBook/CarolDanvers Captain Marvel]]. This is because June was originally created by Creator/KellySueDeconnick, who then brought the character over to the ''Captain Marvel'' book once she started writing it.

* Minor-league ComicBook/IronMan villains [[AnIcePerson Blizzard]] and [[PlayingWithFire Firebrand]] started out fighting Shellhead, but eventually transitioned to fighting street-level heroes like Franchise/SpiderMan after Tony Stark's equipment began to completely outclass theirs. And Shellhead's greatest foe, The Mandarin, took time out - primarily in the 60s and 70s - to deal with other characters. The very first ''Avengers'' annual had Enchantress and Executioner, Living Laser, the original Power Man and the Swordsman working for him to distract the Avengers from his plan of broadcasting worldwide hate-rays. The late 60s had him clash with the Hulk a few times (one time getting Nick Fury involved, another involving the Sandman, normally a Spider-Man foe), another time he kidnapped a peacemaker who was rescued by Captain America, and still another time saw him encounter the Inhumans in an attempt to gain a Makluan artifact. Since then though, he's been sticking with Iron Man.

* The Absorbing Man, who was able to [[PowerCopying mimic and absorb the physical properties of anything he touched]], started out as a recurring enemy of ComicBook/TheMightyThor and remains a charter member of Thor's RoguesGallery. However, he's also tangled with the ComicBook/IncredibleHulk enough times that it's arguably shared custody.

* ComicBook/{{MODOK}} was originally created as a foe for ComicBook/CaptainAmerica. However, in his role as leader of AIM, he's increasingly become an antagonist of ComicBook/IronMan. And then the ComicBook/IncredibleHulk, as he created ComicBook/RedHulk.

* The Super-Skrull originated as a ''ComicBook/FantasticFour'' foe (even having [[AllYourPowersCombined the combined abilities of all four members of the team]]), but quickly became a general cosmic villain (and sometimes AntiVillain), fighting Kree-based heroes like [[ComicBook/{{Captain Marvel|MarvelComics}} Mar-Vell]] and ComicBook/CarolDanvers and showing up in ComicBook/SilverSurfer's book during the 90s. He's also faced off against other Earth heroes like Thor, the Hulk, the Avengers, Doctor Strange, [[ComicBook/SubMariner Namor]] and even Tigra on occasion.

** Juggernaut also has a long-standing rivalry with the Hulk, as the irresistible force to Hulk’s immovable object, and has clashed with him many times over the years.

* Cobalt Man was originally a very minor Silver Age Comicbook/XMen villain, but soon drifted away from that corner of the Marvel Universe and instead fought characters like the Hulk and Comicbook/TheDefenders.

* Taken to the extreme in ''WesternAnimation/UltimateSpiderMan2012'', as part of the show's apparent attempt to be as different as possible to the traditional Spider-Man formula. So far, the show has largely avoided classic Spider-Man antagonists, the only ones showing up after more than ''twenty'' episodes being ComicBook/{{Venom}} ([[spoiler:with Harry Osborn as the host instead of Eddie Brock, though the symbiote later goes to Flash Thompson and turn him into Agent Venom as it does in the comics]]), ComicBook/DoctorOctopus, ComicBook/NormanOsborn (who doesn't become the Green Goblin until the ''season finale'') and Sandman. The other episodes involve either crossover episodes with other heroes involving villains from the guest-star's rogue gallery (Living Laser for ComicBook/IronMan, Loki for [[ComicBook/TheMightyThor Thor]], Zzzax for [[ComicBook/IncredibleHulk Hulk]], Mesmero and ComicBook/{{Sabretooth}} for ComicBook/{{Wolverine}}) or villains from other Rogues Galleries who are treated like they were Spider-Man's regular villains (Doctor Doom and the Frightful Four, whom are Fantastic Four villains, Batroc the Leaper, whom is a Captain America villain, ComicBook/{{Taskmaster}}, who debuted as an Avengers villain, Whirlwind, originally a foe of Ant-Man, the ComicBook/{{Juggernaut|MarvelComics}} (though justified in that there was one notable comic story where Spider-Man did fight Juggernaut)...) As an added twist, some of Spider-Man's foes are now tied to other heroes, such as Kraven being the one who killed ComicBook/WhiteTiger's father, and the Scorpion being from the same mythical city as ComicBook/IronFist. Even though the show did eventually bring in more Spider-Man rogues and storylines, the aforementioned Taskmaster becomes TheHeavy in the first half of season 3, where he recruits potential new SHIELD heroes [[spoiler:to spring Green Goblin from prison, leading to Goblin's travels across the Spider-Verse]], and in season 4, ComicBook/{{HYDRA}} and its leader Arnim Zola, both foes of Captain America and SHIELD (the latter being the mentors to Spider-Man and other heroes) begin to back the Sinister Six, and Crossbones, another foe of Cap and SHIELD, [[spoiler:is selected by HYDRA to replace Dr. Curt Connors as the Lizard when Spider-Man successfully cures Connors for good]].

* ComicBook/DoctorDoom was created to be the main nemesis of the ComicBook/FantasticFour. While he still maintains that role to the present day, he has since become one of the overall Big Bads of the Marvel Universe and has fought pretty much every single Marvel hero. Most prevalent are his tussles with ComicBook/BlackPanther, which makes sense because Panther was originally introduced as a Fantastic Four ally and a GoodCounterpart to Doom in the first place. Doom is also known for his roles in classic ComicBook/IronMan stories and the graphic novel ''Triumph & Torment'' where he meets ComicBook/DoctorStrange. Even other villains are not safe from Doom. He will gladly co-op with the heroes if he feels it serves his interests (of course, [[ChronicBackstabbingDisorder once the interests are served...]]) This is so pronounced that it's even reflected in marketing. For instance, Creator/{{Hasbro}}'s "Titan Hero" action figure line usually references the installment each hero or villain comes from (''Film/IronMan3'', ''WesternAnimation/AvengersAssemble'', ''Film/ThorTheDarkWorld'', ''Film/GuardiansOfTheGalaxy2014'', etc.), but the packaging for the Doctor Doom figure contains no indication that he belongs to the Fantastic Four franchise. One of the most famous storylines with him as the BigBad was ''ComicBook/TheChildrensCrusade''. It involved many named characters such as the ComicBook/YoungAvengers, the ComicBook/{{Avengers}}, ComicBook/XMen, and even [[ComicBook/XFactor2006 X-Factor]] -- yet the first family themselves were no shows.

* ''Annihilation Conquest'' does a similar thing - Avengers villain (created by ComicBook/AntMan) ComicBook/{{Ultron}} takes control over the Phalanx, a race mostly known for their fights with the X-Men, as well as a few lesser-known villains like the Avengers' enemy Ultra-Adaptoid or the Fantastic Four's foe Blastaar, and then goes against cosmic heroes. Ultron later returned to fighting the Avengers, though.

* Speaking of, the High Evolutionary originated in the pages of ''ComicBook/TheMightyThor'', but has since gone on to encounter the Avengers, the Fantastic Four, [[ComicBook/{{Warlock}} Adam Warlock]], the Silver Surfer, the X-Men, the ComicBook/GuardiansOfTheGalaxy, the ComicBook/HeroesForHire, the ComicBook/UncannyAvengers and even the ComicBook/NewWarriors. What makes him somewhat unique is that he is [[HeelFaceRevolvingDoor often an ally rather than an enemy]], depending on who is writing at the time. He notably appeared as the main antagonist of the ''Evolutionary War'' CrisisCrossover during the 80s, where his machinations threatened pretty much the entire Marvel Universe. He also played a role in the origins of ComicBook/ScarletWitch, ComicBook/{{Quicksilver}} and ComicBook/SpiderWoman.

* ComicBook/{{Thanos}} first appeared as an enemy of Iron Man. This is because Thanos's creator, Jim Starlin, was offered to write an issue of Iron Man's comic and created Thanos to be the villain for that issue. When Starlin began writing Captain Marvel he reintroduced Thanos and the rest is history. Thanos is now linked with the ''ComicBook/SilverSurfer'' mythos, (Marvel Comics') ComicBook/{{Captain Marvel|MarvelComics}}, and [[ComicBook/{{Warlock}} Adam Warlock]]. As of 2021, he’s also become a major villain for his extended family, the ComicBook/{{Eternals}}. Like Mephisto, he's now pretty much a general enemy of the entire lineup of "Cosmic Marvel" characters, if not the whole Marvelverse. Interestingly enough, the ''Franchise/MarvelCinematicUniverse'' reverses this with Thanos being shown in some later films to have started off already a major threat in space (at least personally to his adoptive daughters [[Characters/GuardiansOfTheGalaxyModern Gamora]] and [[Characters/GuardiansOfTheGalaxyModern Nebula]]), but his onscreen debut is ''Film/TheAvengers2012'', where he masterminds the plot and eventually becomes the main threat of the Avengers, and the ArchEnemy and EvilCounterpart of Iron Man, ironically the very character he originally faced.

* Fin Fang Foom was originally a general Franchise/MarvelUniverse monster. He became an ComicBook/IronMan villain to the point that he has appeared in both ''WesternAnimation/IronMan'' and ''WesternAnimation/IronManArmoredAdventures'' cartoon series, was featured in [[WesternAnimation/TheInvincibleIronMan the animated movie]], and was considered as a foe for the live-action ''Film/IronMan'' movie... presumably without [[MonsterModesty the purple shorts]]. He still shows up in a FreezeFrameBonus, [[http://www.zimbio.com/A+Closer+Look+at+Marvel%27s+Many+Easter+Eggs/articles/5k4dcA3Hvm9/Fin+Fang+Foom+Makes+Appearance on a billboard]].

* Grey Gargoyle was always a Thor foe. However, he's faced Captain America and Falcon a few times and got on Nick Fury's attention when he hired himself out to AIM. He's basically faced most of the major Marvel heroes following ''Acts of Vengeance'': Hulk, She-Hulk, Spider-Man, Iron Man, and the Fantastic Four. It probably helped that he appeared on the cover of an Iron Man comic in the 90s that led to him being cast in ''WesternAnimation/IronMan'' as one of Mandarin's henchmen.

* The “Armor Wars” two-parter in ''WesternAnimation/IronMan'' sees the title character hunting down various armored characters from across the Marvel Universe, including the Beetle (originally a Human Torch villain and best known for fighting Spider-Man) and Stilt-Man (an enemy of Daredevil).

* Speaking of, the High Evolutionary originated in the pages of ''ComicBook/TheMightyThor'', but has since gone on to encounter the Avengers, the Fantastic Four, ComicBook/AdamWarlock, the Silver Surfer, the X-Men, the ComicBook/GuardiansOfTheGalaxy, the ComicBook/HeroesForHire, the ComicBook/UncannyAvengers and even the ComicBook/NewWarriors. What makes him somewhat unique is that he is [[HeelFaceRevolvingDoor often an ally rather than an enemy]], depending on who is writing at the time. He notably appeared as the main antagonist of the ''Evolutionary War'' CrisisCrossover during the 80s, where his machinations threatened pretty much the entire Marvel Universe. He also played a role in the origins of ComicBook/ScarletWitch, ComicBook/{{Quicksilver}} and ComicBook/SpiderWoman.

* ComicBook/{{Thanos}} first appeared as an enemy of Iron Man. This is because Thanos's creator, Jim Starlin, was offered to write an issue of Iron Man's comic and created Thanos to be the villain for that issue. When Starlin began writing Captain Marvel he reintroduced Thanos and the rest is history. Thanos is now linked with the ''ComicBook/SilverSurfer'' mythos, (Marvel Comics') ComicBook/{{Captain Marvel|MarvelComics}}, and ComicBook/AdamWarlock. As of 2021, he’s also become a major villain for his extended family, the ComicBook/{{Eternals}}. Like Mephisto, he's now pretty much a general enemy of the entire lineup of "Cosmic Marvel" characters, if not the whole Marvelverse. Interestingly enough, the ''Franchise/MarvelCinematicUniverse'' reverses this with Thanos being shown in some later films to have started off already a major threat in space (at least personally to his adoptive daughters [[Characters/GuardiansOfTheGalaxyModern Gamora]] and [[Characters/GuardiansOfTheGalaxyModern Nebula]]), but his onscreen debut is ''Film/TheAvengers2012'', where he masterminds the plot and eventually becomes the main threat of the Avengers, and the ArchEnemy and EvilCounterpart of Iron Man, ironically the very character he originally faced.

* ComicBook/DoctorDoom was created to be the main nemesis of the ComicBook/FantasticFour. While he still maintains that role to the present day, he has since become one of the overall Big Bads of the Marvel Universe and has fought pretty much every single Marvel hero. Most prevalent are his tussles with ComicBook/BlackPanther, which makes sense because Panther was originally introduced as a Fantastic Four ally and a GoodCounterpart to Doom in the first place. Doom is also known for his roles in classic ComicBook/IronMan stories and the graphic novel ''Triumph & Torment'' where he meets ComicBook/DoctorStrange. Even other villains are not safe from Doom. He will gladly co-op with the heroes if he feels it serves his interests (of course, [[ChronicBackstabbingDisorder once the interests are served...]]) This is so pronounced that it's even reflected in marketing. For instance, Creator/{{Hasbro}}'s "Titan Hero" action figure line usually references the installment each hero or villain comes from (''Film/IronMan3'', ''WesternAnimation/AvengersAssemble'', ''Film/ThorTheDarkWorld'', ''Film/GuardiansOfTheGalaxy2014'', etc.), but the packaging for the Doctor Doom figure contains no indication that he belongs to the Fantastic Four franchise. One of the most famous storylines with him as the BigBad was ''ComicBook/TheChildrensCrusade''. It involved [[LoadsAndLoadsOfCharacters many named characters]] such as the ComicBook/YoungAvengers, the ComicBook/{{Avengers}}, ComicBook/XMen, and even [[ComicBook/XFactor2006 X-Factor]] -- yet the first family themselves were no shows.

* The Collector first showed up as an Avengers villain, but thanks to his habit of stealing rare artifacts and organisms, he's clashed with the likes of the ComicBook/SilverSurfer, ComicBook/{{Wolverine}}, the Hulk and ComicBook/StarLord. The third ''ComicBook/ContestOfChampions'' series also had him as a general threat who, alongside the Maestro, kidnapped a number of Marvel characters from across the Multiverse to force them to fight to the death.

** On account of the fact that Spider-Man is more of an all-ages character than Daredevil and far more ubiquitous and popular, i.e. it's easier to greenlight a Spider-Man cartoon than a Daredevil one, Kingpin in multiple media still shows up as a regular part of Spider-Man's Rogues Gallery in diverse animated adaptations and video games. His two major live-action appearances have been in Daredevil properties and both of them target a PG-13 to R crowd. He is Spidey's archenemy in the continuity of the [[VideoGame/SpiderManPS4 Insomniac's Spider-Man game]] and BigBad of it's prequel novel (although he is just the WarmupBoss in the game proper, his defeat leading to an EvilPowerVacuum that starts the main conflict of the game), he's appeared as a Spider-Man BigBad in ''WesternAnimation/SpiderManIntoTheSpiderVerse'' (where he [[HeroKiller murders]] one version of Peter), and he's part of a BigBadEnsemble in the ''ComicBook/UltimateSpiderMan'' comics and ''WesternAnimation/SpiderManTheAnimatedSeries'', which still acknowledge him as being a more [[ItsPersonal personal]] foe of [[HeroOfAnotherStory Daredevil]], though he's mostly seen giving Spider-Man grief. In 616 comics, Kingpin still appears as a regular foe of Spider-Man but hasn't been the BigBad of a storyline since ''Back in Black'', which involved Spider-Man [[NoHoldsBarredBeatdown cutting loose]] and mocking Kingpin for having no powers and demonstrating how powerful Peter really is, making it hard for later writers to use him in the traditional way before. As such, Kingpin shows up more as TheManBehindTheMan and crime broker for other bad guys than a physical threat in his own right. However, perhaps due to his association with the more adult-oriented Daredevil, the Kingpin does ''not'' appear in the ''WesternAnimation/UltimateSpiderMan'' or ''WesternAnimation/MarvelsSpiderMan'' cartoons, being left out in favor of different crime lord rogues that were solely Spider-Man villains, most notably Hammerhead.

* The various Green Goblins were notable for being solely Spider-Man villains, never antagonizing other New York-based heroes as ComicBook/DoctorOctopus or Electro would. Since ''ComicBook/SecretInvasion'', however, ComicBook/NormanOsborn has been transformed into an over-riding BigBad of the Franchise/MarvelUniverse, specifically clashing with the Comicbook/NewAvengers. After trying to take the Avengers again with another team of Comicbook/DarkAvengers and a H.A.M.M.E.R. made up of ComicBook/{{HYDRA}} and A.I.M. personnel, he has gone back to being a Spidey villain. [[spoiler:Firmly reestablished at the GrandFinale of ''Comicbook/SuperiorSpiderMan''.]] The run of Captain America by Ta-Nehisi Coates would then include him in the Power Elite that opposed Captain America.
* Since his resurrection Kraven the Hunter and his daughter Ana have been seen fighting other superheroes on a daily basis, mostly related to Spider-Man like ComicBook/{{Venom}}, [[ComicBook/SpiderWoman Spider-Girl]] or ComicBook/ScarletSpider, but Comicbook/BlackPanther and Comicbook/IncredibleHulk are also fair game. It helps Kraven seems to now live in the Savage Land, a place commonly visited by various superheroes.

* Speaking of, the High Evolutionary originated in the pages of ''Comicbook/TheMightyThor'', but has since gone on to encounter the Avengers, the Fantastic Four, Comicbook/AdamWarlock, the Silver Surfer, the X-Men, the Comicbook/GuardiansOfTheGalaxy, the Comicbook/HeroesForHire, the Comicbook/UncannyAvengers and even the Comicbook/NewWarriors. What makes him somewhat unique is that he is [[HeelFaceRevolvingDoor often an ally rather than an enemy]], depending on who is writing at the time. He notably appeared as the main antagonist of the ''Evolutionary War'' CrisisCrossover during the 80s, where his machinations threatened pretty much the entire Marvel Universe. He also played a role in the origins of Comicbook/ScarletWitch, Comicbook/{{Quicksilver}} and Comicbook/SpiderWoman.

* The Phoenix Force, while going back and forth through the HeelFaceRevolvingDoor at a rate of knots and often subject to BlueAndOrangeMorality, is usually near inextricably related to the X-Men and their associated books, such as {{ComicBook/Excalibur}} - and in the latter case, only because ComicBook/RachelSummers was on the roster. Recently, however, the entity first became a global threat in ''ComicBook/AvengersVsXMen'', then shuffled over to the ''Thor'' books under Jason Aaron's pen, making an important appearance in ''ComicBook/Thor2014'' and the King Thor sections of his ''Thor'' run, being revealed to have a complicated relationship with Asgard (having hooked up with both Odin and Thor in the past). While she simultaneously appeared in the ''ComicBook/JeanGrey'' book in the run up to ''ComicBook/PhoenixResurrection'', the culmination of that book had Jean firmly tell the entity to sod off and leave her alone, suggesting that she's out of the X-Men's orbit for the time being. The Phoenix Force returned in a big way for a storyline in ''Comicbook/TheAvengersJasonAaron'', which ended with former Avenger and recurring Daredevil ally Echo becoming the entity’s new host.

* Swarm was originally created as a Comicbook/{{Champions|1975}} villain, but soon became far more associated with Spider-Man.
* Fin Fang Foom was originally a general Franchise/MarvelUniverse monster. He became an Comicbook/IronMan villain to the point that he has appeared in both ''WesternAnimation/IronMan'' and ''WesternAnimation/IronManArmoredAdventures'' cartoon series, was featured in [[WesternAnimation/TheInvincibleIronMan the animated movie]], and was considered as a foe for the live-action ''Film/IronMan'' movie... presumably without [[MonsterModesty the purple shorts]]. He still shows up in a FreezeFrameBonus, [[http://www.zimbio.com/A+Closer+Look+at+Marvel%27s+Many+Easter+Eggs/articles/5k4dcA3Hvm9/Fin+Fang+Foom+Makes+Appearance on a billboard]].

* Black Knight (Nathan Garrett) was originally an enemy of ComicBook/AntMan and ComicBook/TheWasp, but was a founding member of the Masters of Evil, the first supervillain team foes for ComicBook/TheAvengers, and then ended up better known as an enemy of Comicbook/IronMan before being replaced by his heroic nephew. It got to the point where in ''WesternAnimation/IronManArmoredAdventures'', he's depicted exclusively as an Iron Man villain.
* Speaking of Black Knight, Dreadknight was later introduced in the pages of ''Iron Man'' as something of a replacement {{Expy}}, being a knight-themed supervillain with a high-tech lance, a similar costume and even the same flying horse. However, these same qualities have also led him to battle Dane Whitman, the heroic Comicbook/BlackKnight (and Garrett's RedeemingReplacement), with Dreadknight effectively serving as Dane's EvilCounterpart.
* ComicBook/{{Mephisto}} works well as a deliberate example: He was originally introduced in the ''ComicBook/SilverSurfer'' series, but has spent stints as an adversary of both Comicbook/TheMightyThor and Ghost Rider. To the modern reader, though, he's best known for his role in ''Comicbook/OneMoreDay'', a Spider-Man story. Mephisto is best understood as a member of the RoguesGallery for the wider Marvel Universe, rather than any one hero, which is fitting as he is basically a stand-in for {{Satan}}. He has tangled with nearly every single major hero and several villains, and is a lot more personal for many.
* Crossfire first appeared as an enemy of Comicbook/MoonKnight in an issue of ''Comicbook/MarvelTwoInOne'', with the two even having a shared past from their time as CIA agents. However, he's since become more associated with Hawkeye and the Scott Lang version of Comicbook/AntMan, particularly since his brother, Darren Cross, was the latter's StarterVillain.

* Comicbook/{{Thanos}} first appeared as an enemy of Iron Man. This is because Thanos's creator, Jim Starlin, was offered to write an issue of Iron Man's comic and created Thanos to be the villain for that issue. When Starlin began writing Captain Marvel he reintroduced Thanos and the rest is history. Thanos is now linked with the ''ComicBook/SilverSurfer'' mythos, (Marvel Comics') ComicBook/{{Captain Marvel|MarvelComics}}, and Comicbook/AdamWarlock. As of 2021, he’s also become a major villain for his extended family, the ComicBook/{{Eternals}}. Like Mephisto, he's now pretty much a general enemy of the entire lineup of "Cosmic Marvel" characters, if not the whole Marvelverse. Interestingly enough, the ''Franchise/MarvelCinematicUniverse'' reverses this with Thanos being shown in some later films to have started off already a major threat in space (at least personally to his adoptive daughters [[Characters/GuardiansOfTheGalaxyModern Gamora]] and [[Characters/GuardiansOfTheGalaxyModern Nebula]]), but his onscreen debut is ''Film/TheAvengers2012'', where he masterminds the plot and eventually becomes the main threat of the Avengers, and the ArchEnemy and EvilCounterpart of Iron Man, ironically the very character he originally faced.

* Nebula was conceived as the nemesis of the second {{Comicbook/Captain Marvel|MarvelComics}}, but remained a general Avengers villain after Captain Marvel mostly disappeared from the book and focused more personally on Starfox. Then she became a frequent opponent of The Silver Surfer before appearing in Loki's stories when he was trying to reform. Then she joined Gamora's team Graces only to betray Gamora and turn the group against her. Then Nebula became a general The Guardians Of The Galaxy enemy.
* The Celestials originated in Creator/JackKirby's ''Comicbook/TheEternals'', but have since crossed paths with [[Comicbook/TheMightyThor Thor]], the Comicbook/FantasticFour, Comicbook/TheAvengers and even the Comicbook/XMen.
* Comicbook/{{Sabretooth}} was a foe of Comicbook/IronFist. Incidentally, Sabretooth was originally intended to be Wolverine's father by creator Creator/JohnByrne (he was based on Byrne's rejected design for Wolverine sans mask), but ended up getting dumped onto the Iron Fist title when Claremont and Cockrum weren't interested. Years later, Claremont decided to bring Sabretooth into the Wolverine fold; though he has yet to be confirmed as his father, he still is his ArchEnemy.

* The first Silver Samurai, another character closely associated with Wolverine and the X-Men, also first appeared fighting Daredevil. And while he's best known as a Wolverine villain now, he's also clashed with Comicbook/ShangChi, Comicbook/BlackWidow and Spider-Man. His son, Shin Harada, originated as a Wolverine villain, but also battled Comicbook/JaneFoster during her time as the new ComicBook/{{Thor|2014}}.
* Nuke first appeared as an enemy of Daredevil in the iconic ''[[Comicbook/DaredevilBornAgain Born Again]]'' storyline, but his ties to Project Rebirth (and, by extension, Weapon X), as well as his general concept of being a crazed SuperSoldier, made him a perfect fit for the likes of Captain America and Wolverine.
* The Collector first showed up as an Avengers villain, but thanks to his habit of stealing rare artifacts and organisms, he's clashed with the likes of the Comicbook/SilverSurfer, Comicbook/{{Wolverine}}, the Hulk and Comicbook/StarLord. The third ''Comicbook/ContestOfChampions'' series also had him as a general threat who, alongside the Maestro, kidnapped a number of Marvel characters from across the Multiverse to force them to fight to the death.
* Lucifer started off as a very minor X-Men villain before eventually battling characters like Iron Man and Comicbook/TheFalcon. His successor, Dominus, would later fight the Comicbook/WestCoastAvengers.

** Omega Red started off as an X-Men foe before focusing squarely on Wolverine. In the ComicBook/UltimateMarvel universe, Omega Red is primarily a foe of [[Comicbook/UltimateSpiderMan Peter Parker]] and his successor, [[AffirmativeActionLegacy Miles Morales]]. Likewise, ComicBook/{{Deadpool}} made his Ultimate debut fighting Spider-Man (though the arc was also a sequel to an ''ComicBook/UltimateXMen'' arc and featured the team).

** Bolivar Trask is most associated with the ComicBook/XMen in mainstream Marvel continuity, but in the [[ComicBook/UltimateMarvel Ultimate Universe]] he became integrated into Comicbook/UltimateSpiderMan's mythos, eventually becoming the BigBad of [[VideoGame/UltimateSpiderMan the video game adaptation]].

* The [[PsychoForHire contract killer]] Boomerang, who uses deadly gimmick boomerangs as his weapons, originally started out fighting [[Comicbook/IncredibleHulk the Hulk]], before he moved on to become a semi-regular Franchise/SpiderMan villain after writers realized that trick boomerangs versus the most powerful creature on Earth was a bit of a mismatch. Boomerang even appears in the Uncanny X-Men UsefulNotes/{{Nintendo|EntertainmentSystem}} game by LJN even though he's neither a X-Men enemy nor a mutant.
* Mister Hyde, a villain based on ''Literature/TheStrangeCaseOfDrJekyllAndMrHyde'', started out as a [[Comicbook/TheMightyThor Thor]] villain but would later move on to become a Comicbook/{{Daredevil}} regular, although he also took the time to mess with Franchise/SpiderMan, Comicbook/CaptainAmerica, Comicbook/GhostRider, and [[Comicbook/IncredibleHulk the Hulk]], finally settling in to become a regular foe of Cap, DD and the Big Green Machine. These days he seems to have moved to fighting teen heroes, considering his appearances in both ''ComicBook/YoungAvengers'' and ''ComicBook/AllNewGhostRider''. He was later revealed as the father of ComicBook/DaisyJohnson, and has been a foe of her as well.
* Cobra, Mister Hyde's sometime partner, also started out as a [[Comicbook/TheMightyThor Thor]] villain. He quickly figured out that his 'powers' of being double-jointed and crawling on his belly didn't make him capable of challenging the god of thunder and became a foe of Comicbook/{{Daredevil}} and Comicbook/CaptainAmerica.
* In the very early days of the Silver Age Franchise/MarvelUniverse, the ComicBook/FantasticFour's ComicBook/HumanTorch had his own rogues gallery as a solo hero. Two of his mainstays, the Wizard and the Trapster, would later become enemies of the Fantastic Four, with the Wizard becoming an EvilCounterpart to [[ComicBook/MisterFantastic Reed Richards]] and even forming his own EvilCounterpart team in the Frightful Four, of which the Trapster was a charter member. The Trapster and the Beetle, another long-standing enemy of the Torch, would also become recurring enemies of Franchise/SpiderMan. It's so pronounced that in both the ''Ultimate Spider-Man'' [[Comicbook/UltimateSpiderMan comic]] and [[WesternAnimation/UltimateSpiderMan TV show]], the Beetle is more or less treated as a straight-up Spidey villain (being a founding member of the Sinister Six there). Though during the days he wore his first costume, he fought Daredevil more often, only to completely abandon him with his upgrade, choosing Iron Man as a secondary nemesis. The Eel also originally debuted as a foe of the Human Torch before becoming a semi-regular Comicbook/{{Daredevil}} villain.
* Current Beetle debuted as a one-time enemy of ComicBook/CaptainAmerica, but is now better known for her role in ''Comicbook/TheSuperiorFoesOfSpiderMan''. Of course, Spider-Man was TheGhost in that series, and writer Nick Spencer wrote her into a DatingCatwoman scenario with Scott Lang during his later run on Comicbook/AntMan, so she probably rates more highly in Scott's Rogues Gallery at this point. She was fully shunted into Spider-Man's gallery come ''ComicBook/NickSpencersSpiderMan''.
* Many of the enemies the various members of Comicbook/TheAvengers had faced as solo heroes would later become enemies of the team as a whole, with characters like [[MadScientist Egghead]], an enemy of ComicBook/AntMan, a.k.a. Henry Pym; ComicBook/BaronZemo, (an enemy of Comicbook/CaptainAmerica and the founder of the original Masters of Evil); ComicBook/{{Loki}}, an enemy of Comicbook/TheMightyThor (unique in that he ''also'' was their StarterVillain); and the Mandarin, the ArchEnemy of Comicbook/IronMan, all becoming some of the Avengers' worst enemies. This would also get inverted. The first incarnation of the Masters of Evil featured the Black Knight as a foil for Wasp and Giant Man and Radioactive Man as the foil for Thor. Soon after, both became regular enemies of Comicbook/IronMan.
* Speaking of Comicbook/BaronZemo, though he's best known as an enemy of the original Captain America, he's also menaced Steve's successors to the mantle, Comicbook/BuckyBarnes and [[Comicbook/TheFalcon Sam Wilson]]. Zemo's connections to the Thunderbolts have also given him a grudge against Comicbook/{{Hawkeye}}, leading to appearances as a major antagonist in both ''Hawkeye: Blind Spot'' and ''Comicbook/OldManHawkeye''. Lastly, he clashed with Comicbook/ThePunisher during the latter's brief stint as the new Comicbook/WarMachine, and subsequently appeared as one of the main villains of the ensuing 2018 ''Punisher'' relaunch.
* Graviton is primarily an Avengers villain, but was also a major recurring adversary of the original Comicbook/{{Thunderbolts}}. He’s also faced other heroes like Comicbook/{{Shuri|Marvel Comics}} and Miles Morales.
* Michael Korvac was first introduced as a one time enemy of ''Comicbook/TheDefenders'', but later became best known as the main antagonist of ''Comicbook/TheKorvacSaga'' in ''Comicbook/TheAvengers''.

* Comicbook/{{Mystique}} first appeared in ''[[Comicbook/CarolDanvers Ms. Marvel]]'' and was originally slated to be her ArchEnemy. She's pretty much entirely an X-Villain nowadays, and her history with Ms. Marvel (such as killing her boyfriend) has been all but forgotten. She did return to torment Ms. Marvel in Carol's later series.

* The Sons of the Serpent originated in Creator/StanLee's run on ''Comicbook/TheAvengers'', but later had memorable battles with Comicbook/{{Daredevil}} and Comicbook/TheDefenders. Their status as [[PoliticallyIncorrectVillain a white supremacist organization dedicated to ridding America of minorities]] has also led to run-ins with the likes of [[Comicbook/TheFalcon Sam Wilson]], Comicbook/MonicaRambeau and the Comicbook/YoungAvengers.
* This goes for a lot of the evil organizations of the Marvel Universe like Comicbook/{{HYDRA}} (originally enemies of Comicbook/NickFury and Comicbook/{{SHIELD}}), A.I.M. (originally enemies of Captain America) and the Hand (originally enemies of Comicbook/{{Daredevil}}), all of whom have fought various solo superheroes and teams as general threats to the Marvel Universe.
* Comicbook/{{Apocalypse}} first appeared in ''ComicBook/XFactor'' as the leader of the Alliance of Evil (a role, again, originally intended for the Owl) eventually becoming their BigBad, getting killed, and, upon resurrection, graduating to become one of the ComicBook/XMen's most powerful foes and being {{retcon}}ned as Comicbook/{{Cable}}'s archenemy. The former might not be quite enough to qualify as this trope since the incarnation of X-Factor that had Apocalypse as the BigBad consisted of the original five X-Men, making the whole thing X-Men in all but name to begin with. Cable, on the other hand, while very much an X-Men related character, especially due to him being the future son of Cyclops, has his own distinct rogues gallery that usually only overlaps with the X-Men during crossover events. Since Jason Aaron took over the Thor title and the beginning of ''ComicBook/UncannyAvengers'' (where he and Thor were manipulated into a confrontation by Kang), he also became a part time enemy of Thor - albeit usually in flashbacks when fighting a pre-Mjolnir Thor, who holds something of a grudge against him for a beating that Apocalypse handed out to him. Since Apocalypse has been worshipped as a god, and is a PhysicalGod in terms of raw power anyway, it's fitting.

* In his initial few appearances, Comicbook/KangTheConqueror was a Comicbook/FantasticFour villain called Rama-Tut, with it even being implied that he was a future descendent of Doctor Doom. After taking on his far better known name and appearance as Kang, he primarily battled the Avengers, though he still shows up to menace the FF and other heroes from time to time.
* The first Moonstone was a Captain America villain, and the woman who would eventually steal his powers as the second Moonstone was initially an EvilMinion who was of little concern to Captain America. When she became a full fledge super villain she started off as a Hulk foe, but became more of a general Avengers villain after joining the Masters of Evil, forming a direct rivalry with the second [[Comicbook/MonicaRambeau Captain Marvel]]. Then she became a rival to Baron Zemo and the third Captain Marvel/second Photon, Genis-Vell during ''Comicbook/{{Thunderbolts}}''. Then during Comicbook/DarkReign, she was positioned as Ms. Marvel's EvilCounterpart in Norman Osborn's ComicBook/DarkAvengers. She continues to oppose Comicbook/CarolDanvers as she becomes Captain Marvel #6, though not always willingly.
* June Covington, aka "Toxic Doxie", started off as one of Norman Osborn's allies from his limited series. She went on to menace the Comicbook/NewAvengers as the ComicBook/DarkAvengers' impostor Scarlet Witch, but has since settled on terrorizing [[ComicBook/CarolDanvers Captain Marvel]]. This is because June was originally created by Creator/KellySueDeconnick, who then brought the character over to the ''Captain Marvel'' book once she started writing it.
* Blackout was originally an obscure Comicbook/{{Nova}} villain, but is probably best remembered for his role in Creator/RogerStern's ''Comicbook/TheAvengers'' run, where he battled the team as part of the [[LegionOfDoom Masters of Evil]]. On a more specific level, his powers were used to counteract those of [[Comicbook/MonicaRambeau Captain Marvel]].
* Arcade debuted in the pages of ''Marvel Team-Up'', a title that had Spider-Man teaming up with other Marvel heroes, but these days is better known as an ComicBook/XMen villain. He did resurface in TheNewTwenties in ''ComicBook/NickSpencersSpiderMan'' as part of the ''ComicBook/{{Hunted}}'' arc before jumping back to the X-Men in ''ComicBook/{{Hellions}}''.

** Arcade was the main villain for young Marvel superheroes for a time, trapping the Comicbook/AvengersAcademy kids and the [[UsefulNotes/TheModernAgeOfComicBooks Modern Age]] Young Allies in Murderworld, and doing the same in ''Comicbook/AvengersArena'' with more teen superheroes.
* The demon Blackheart debuted in ''Daredevil'', though now spends most of his time messing with Comicbook/GhostRider, even appearing as the villain in [[Film/GhostRider the movie adaptation]]. He also shows up in ComicBook/XMen from time to time (amongst others), even at one point serving as the Black King of the Hellfire Club. He’s also had run-ins with Comicbook/MilesMorales and Comicbook/TheFalcon.

* Ghost Rider villain Night Terror eventually became a Comicbook/{{Blade}} antagonist. Although it did not last too long, since he really only lasted in the first place because none of Ghost Rider attempts to kill him stuck, but Blade was actually equipped end him for good.

* Minor-league Comicbook/IronMan villains [[AnIcePerson Blizzard]] and [[PlayingWithFire Firebrand]] started out fighting Shellhead, but eventually transitioned to fighting street-level heroes like Franchise/SpiderMan after Tony Stark's equipment began to completely outclass theirs. And Shellhead's greatest foe, The Mandarin, took time out - primarily in the 60s and 70s - to deal with other characters. The very first ''Avengers'' annual had Enchantress and Executioner, Living Laser, the original Power Man and the Swordsman working for him to distract the Avengers from his plan of broadcasting worldwide hate-rays. The late 60s had him clash with the Hulk a few times (one time getting Nick Fury involved, another involving the Sandman, normally a Spider-Man foe), another time he kidnapped a peacemaker who was rescued by Captain America, and still another time saw him encounter the Inhumans in an attempt to gain a Makluan artifact. Since then though, he's been sticking with Iron Man.

* Moses Magnum started out fighting Spider-Man and Comicbook/ThePunisher, but seems to have eventually settled on antagonizing Comicbook/BlackPanther. Thematically, Magnum and T'Challa are a perfect fit, and ''WesternAnimation/IronManArmoredAdventures'' chose to make Magnum [[YouKilledMyFather murder]] T'Chaka instead of Klaw.

* The Absorbing Man, who was able to [[PowerCopying mimic and absorb the physical properties of anything he touched]], started out as a recurring enemy of Comicbook/TheMightyThor and remains a charter member of Thor's RoguesGallery. However, he's also tangled with the Comicbook/IncredibleHulk enough times that it's arguably shared custody.
* Comicbook/DoctorDoom was created to be the main nemesis of the ComicBook/FantasticFour. While he still maintains that role to the present day, he has since become one of the overall Big Bads of the Marvel Universe and has fought pretty much every single Marvel hero. Most prevalent are his tussles with Comicbook/BlackPanther, which makes sense because Panther was originally introduced as a Fantastic Four ally and a GoodCounterpart to Doom in the first place. Doom is also known for his roles in classic ComicBook/IronMan stories and the graphic novel ''Triumph & Torment'' where he meets ComicBook/DoctorStrange. Even other villains are not safe from Doom. He will gladly co-op with the heroes if he feels it serves his interests (of course, [[ChronicBackstabbingDisorder once the interests are served...]]) This is so pronounced that it's even reflected in marketing. For instance, Creator/{{Hasbro}}'s "Titan Hero" action figure line usually references the installment each hero or villain comes from (''Film/IronMan3'', ''WesternAnimation/AvengersAssemble'', ''Film/ThorTheDarkWorld'', ''Film/GuardiansOfTheGalaxy'', etc.), but the packaging for the Doctor Doom figure contains no indication that he belongs to the Fantastic Four franchise. One of the most famous storylines with him as the BigBad was ''ComicBook/TheChildrensCrusade''. It involved [[LoadsAndLoadsOfCharacters many named characters]] such as the ComicBook/YoungAvengers, the ComicBook/{{Avengers}}, ComicBook/XMen, and even [[ComicBook/XFactor2006 X-Factor]] -- yet the first family themselves were no shows.
* Comicbook/{{MODOK}} was originally created as a foe for ComicBook/CaptainAmerica. However, in his role as leader of AIM, he's increasingly become an antagonist of Comicbook/IronMan. And then the Comicbook/IncredibleHulk, as he created Comicbook/RedHulk.
* ''ComicBook/{{Annihilation}}'' has the ComicBook/FantasticFour's long-time foe Annihilus launching a devastating attack on the universe, uniting cosmic heroes like Comicbook/{{Nova}} and the ComicBook/SilverSurfer against him. Even through Annihilus returned a few years later to fight the first family again, he is now generally considered a threat to the entire universe.
* ''Annihilation Conquest'' does a similar thing - Avengers villain (created by ComicBook/AntMan) Comicbook/{{Ultron}} takes control over the Phalanx, a race mostly known for their fights with the X-Men, as well as a few lesser-known villains like the Avengers' enemy Ultra-Adaptoid or the Fantastic Four's foe Blastaar, and then goes against cosmic heroes. Ultron later returned to fighting the Avengers, though.
* In a similar vein, ''ComicBook/WarOfKings'' is driven by conflict between the Kree Empire, ruled by Comicbook/TheInhumans, and the Shi'Ar Empire, ruled by X-Men foe Vulcan. Time will show which group Vulcan will stick to antagonizing.
* The Super-Skrull originated as a ''Comicbook/FantasticFour'' foe (even having [[AllYourPowersCombined the combined abilities of all four members of the team]]), but quickly became a general cosmic villain (and sometimes AntiVillain), fighting Kree-based heroes like [[Comicbook/{{Captain Marvel|MarvelComics}} Mar-Vell]] and Comicbook/CarolDanvers and showing up in Comicbook/SilverSurfer's book during the 90s. He's also faced off against other Earth heroes like Thor, the Hulk, the Avengers, Doctor Strange, [[Comicbook/SubMariner Namor]] and even Tigra on occasion.
* Speaking of [[Comicbook/SubMariner Namor]], while his Silver Age return pegged him as an enemy of the Fantastic Four and Comicbook/MisterFantastic's romantic rival, Stan Lee and Jack Kirby quickly established him as a threat to the wider Marvel Universe by having him also fight the Avengers and X-Men. His constant HeelFaceRevolvingDoor tendencies have led him to clash with a great many Marvel heroes over the years, including Comicbook/BlackPanther and the Comicbook/SquadronSupreme.
* This applies to the Skrulls as a whole. They began as enemies of the Fantastic Four, but gradually became a threat to the entire Marvel Universe, which was cemented by ''Comicbook/SecretInvasion''. Ditto for the Kree, the archenemies of the Skrulls.
* [[EldritchAbomination Shuma-Gorath]] was actually first mentioned in a Creator/RobertEHoward short story, but has been better known for his classic fights against Comicbook/DoctorStrange. He more or less lost his association with the good doctor when he [[UnexpectedCharacter unexpectedly appeared in]] ''VideoGame/MarvelSuperHeroes'', [[AdaptedOut where Strange was absent]]. Due to the Howard connection, Shuma also menaced Comicbook/ConanTheBarbarian in his Marvel series. ''ComicBook/TheThanosImperative'' and a few other appearances helped him get upgraded to universal threat, like Mephisto or Thanos. Similarly, Nightmare started as a ComicBook/DoctorStrange foe, but has since then fought with pretty much everybody.

* Demogorge the God Eater and Amatsu Mikaboshi both debuted as antagonists of Comicbook/TheMightyThor. To modern readers they are probably known as enemies and [[EnemyMine occasional allies]] of Comicbook/TheIncredibleHercules.
* Comicbook/ThePunisher has few reoccurring villains due to his deadly nature but one of his few villains, Jigsaw, started off as a Spider-Man villain, although his introductory story did involve Punisher as well. Punisher himself was a Spider-Man villain; however he was more of an antagonistic AntiHero and now has his own titles where he scuffles with every street level hero when he's not massacring normal criminals.

* The crossover event ''ComicBook/ActsOfVengeance'' best describes this trope. It involves the very idea of [[OpponentSwitch a wide array of super-villains facing heroes they had never met (or at least were villains that weren't part of the heroes' regular gallery)]]. Such examples were Comicbook/AlphaFlight fighting Scorpion, Spider-Man (who was granted cosmic powers at the time) fought Goliath, The Brothers Grimm, Titania, Magneto, Graviton, Trapster, Dragon-Man, and the Tri-Sentinel. Daredevil fought Ultron, Thor fought Juggernaut, Mandarin appears in the X-Men issues, and Rusty and Skids of the ComicBook/NewMutants battle the Vulture. Even Magneto went against the ComicBook/RedSkull for [[BerserkButton very obvious reasons]] (Magneto (a Holocaust survivor) barely tolerated the Red Skull as a co-conspirator under the impression that he was a modern villain using the Skull's mask and image to frighten people. When he realized the Skull was the actual protege of Hitler and WWII war criminal . . . he [[FateWorseThanDeath buried the Skull in a light-less fallout shelter with a dozen jugs of water and sealed it shut]].) Similarly the event ''ComicBook/InfinityWarps'' does the same thing, being an homage to ''Acts of Vengeance''. Across the merged universe it takes place in, superheroes find themselves under attack by other people's enemies.

* Baron von Strucker was introduced as Comicbook/NickFury's ArchEnemy, but, as the leader of Comicbook/{{HYDRA}}, he's also clashed with the likes of Comicbook/{{Daredevil}}, Captain America, the Avengers, Comicbook/{{Wolverine}}, Black Panther and the Comicbook/{{Thunderbolts}}. A memorable issue from Creator/ChrisClaremont’s ''X-Men'' run also revealed that Strucker played a key role in the shared backstory of Comicbook/ProfessorX and Comicbook/{{Magneto}}, having fought against both mutants back when they were young men in the years after World War 2.

* An {{inver|tedTrope}}sion happened to The Pride - they were always antagonists of the ''ComicBook/{{Runaways}}'' and it would be pretty hard to introduce them fighting any other superheroes while their entire point was they kept their operations under their radar. That was the case until the creation of [[Comicbook/NewAvengers Avengers Illuminati]] who were also working in secret from the entire Marvel superheroic community. So of course there exist comics that revealed the two groups clashed back in the days when the Runaways were still only kids.
* After Doctor Sun was defeated in ''ComicBook/TheTombOfDracula'' by the joined forces of Dracula and the vampire hunters, he went to antagonize Comicbook/{{Nova}} and the Comicbook/FantasticFour.

* While ComicBook/{{Magneto}} is primarily known for his [[HeelFaceRevolvingDoor complicated]] relationship with the X-Men, he has tangled with all of Marvel's major heroes as well, particularly the Avengers, Fantastic Four, Thor, and Spider-Man. A key moment in his backstory, where he was deaged to infancy, actually occurred after a fight against Comicbook/TheDefenders.
* With Peter Parker becoming head of Parker Industries during the ComicBook/AllNewAllDifferentMarvel event and Spider-Man dealing with bigger foes, his previous street-level Rogues Gallery is now being handled by Comicbook/MilesMorales, ComicBook/SpiderWoman, and Comicbook/{{Silk}}. Both Silk and Miles have dealt with ComicBook/BlackCat, and Spider-Woman has gone up against Hobgoblin.
* Speaking of Spider-Woman, Morgan Le Fay used to be her arch-nemesis, but now she's a general Marvel Universe villain, mainly tangling with the Avengers. This included an encounter with the ComicBook/DarkAvengers, due to her targeting Doctor Doom for revenge. In the [[ComicBook/SpiderWoman2014 2014 volume]], Spider-Woman mainly fought C-list/D-List villains such as Tiger Shark (a traditional ComicBook/SubMariner villain), the Sandman (a Franchise/SpiderMan villain), and the Blizzard (traditionally an Comicbook/IronMan villain).
* Roxxon Energy, the evil energy MegaCorp, are mostly known for pestering Iron Man, but are also enemies of a few different iterations of Deathlok, most notably Michael Collins, who they transformed into a cyborg commando against his will because [[HeKnowsTooMuch He Knew Too Much]]. They later became a recurring problem for Kaine as the Scarlet Spider, and under new CEO Dario Agger (who's also a Minotaur), they've mainly been an enemy to both Thor and [[Comicbook/Thor2014 Lady Thor]]. Agger, in turn, has since branched out to the ComicBook/ImmortalHulk. In the Comicbook/UltimateMarvel continuity, Roxxon was more of a general villain to almost every hero, being the cause of how most heroes got their powers and behind many atrocities. As the Ultimate Marvel line dwindled down, Roxxon was exclusively a problem for Miles Morales/Spider-Man and his friends. So much so, in the video game ''VideoGame/SpiderManMilesMorales'', Roxxon and their CorruptCorporateExecutive Simon Krieger are the main antagonists. They would again become a pain for Miles in the 616-continuity in ''ComicBook/Champions2020'', along with the other Champions.
* The general public now knows Ronan the Accuser as the villain of the 2014 ''Film/GuardiansOfTheGalaxy'' film, but he actually debuted as a ''ComicBook/FantasticFour'' antagonist, and is now in fact [[HeelFaceTurn not much of a villain at all in the comics]] (to the point of ''teaming up'' with the Guardians in one of his most recent appearances)

* Chemistro was originally an enemy of [[Comicbook/LukeCage Power Man]] and Comicbook/IronFist, but over time moved on to fight other heroes like Iron Man and the Comicbook/NewAvengers.

* During the 70s, there was a giant robot known as Red Ronin, who was designed to battle Franchise/{{Godzilla}}. It did so and later turned into an ally for the giant green lizard. When Marvel lost the rights to Godzilla, Red Ronin ended up being turned into a basic foe for the Marvel Universe as a whole, usually taken over by some random villain to wreck havoc and let the heroes trash. Doctor Demonicus was also created as a Godzilla villain, but went on to face off against Iron Man and the Comicbook/WestCoastAvengers when the Big G’s rights returned to Creator/{{Toho}}.

* Many of Marvel's 2019 annuals were themed under the banner ''Acts of Evil'', with no actual story throughline, but a theme of heroes fighting villains they would normally have nothing to do with, such as [[Comicbook/MsMarvel2014 Ms. Marvel]] versus the Super-Skrull, the Punisher versus the Brood and Comicbook/SheHulk versus Comicbook/{{Bullseye|Marvel Comics}}.

* The Wrecking Crew debuted as [[Comicbook/TheDefenders Defenders]] villains (with the exception of the Wrecker, who was a preexisting Thor baddie), but over time became better known as enemies of the Avengers. In general, they tend to be a fairly popular choice for smaller scale VillainOfTheWeek plots, as their comparatively meager ambitions (usually desiring money rather than world conquest or galactic genocide) makes them perfect filler villains for characters like Wolverine and She-Hulk.
* The Griffin was created as a Comicbook/{{Beast|Marvel Comics}} villain during the brief period where Hank had a solo feature in ''Amazing Adventures''. After Beast's series was cancelled, Griffin drifted throughout the Marvel Universe as an all-purpose villain of sorts, facing the likes of Spider-Man, Comicbook/WonderMan, the Comicbook/{{Champions|1975}}, Namor and various incarnations of the Avengers. He was also eventually revealed to be the father of Yo-Yo Rodriguez in ''Comicbook/SecretWarriors''.

* Viper started off as a Comicbook/CaptainAmerica foe and is usually an enemy of Comicbook/NickFury and ComicBook/{{SHIELD}} as well (to the point that she's now known as [[ComicBook/{{HYDRA}} Madame Hydra]]). Despite this, she is one of the antagonists in ''Film/TheWolverine''. Understandable since despite her connections to Captain America and S.H.I.E.L.D., she has appeared in several notable Wolverine storylines[[note]]This depiction was InNameOnly however[[/note]].

* ''WesternAnimation/AvengersAssemble'' uses Impossible Man, another Comicbook/FantasticFour enemy, as well as Doctor Doom. [[LegionOfDoom The Cabal]], originally created as the EvilCounterpart of ComicBook/TheIlluminati, act as the first main antagonists, founded by Captain America's ArchEnemy Red Skull and his other enemy MODOK (whom is more acknowledged here by his later encounters with Iron Man), with Dracula, ComicBook/SubMariner rogue Attuma, and Hyperion (a member of the ComicBook/SquadronSupreme, though his overall depiction is closer to the villainous Squadron Sinister version) also added. Later arcs find ways to add Thanos and the Black Order (though CrisisCrossover events do see Thanos face the team in the comics despite being better known for his encounters with cosmic heroes), a new Cabal featuring [[spoiler: the Leader, Zola, Enchantress, and Loki]], all enemies of [[spoiler:Hulk, Captain America, and Thor, though Loki was the Avengers' original StarterVillain]], and Madame Masque, whom normally faced Iron Man and Hawkeye (Kate Bishop), was used in a season that was heavily centric to ComicBook/BlackPanther, just to name a few, that same season mainly having his enemy [[Comicbook/{{Killmonger}} Erik Killmonger]] as the main antagonist.
* ''WesternAnimation/TheAvengersEarthsMightiestHeroes'' essentially made the ComicBook/BlackPanther villain Klaw into an Comicbook/AntMan foe, as Ant-Man is the one who mangles his hand and later comes up with the strategy to defeat him. This left Black Panther without an ArchEnemy or someone to yell YouKilledMyFather at, so the writers made Man-Ape into his father's murderer instead. Klaw does still participate from the shadows, but its only because T'Chaka's fight with Man-Ape was really a TrialByCombat fight to the death for the throne, where Klaw's sabotage gave Man-Ape the advantage and victory.
* The sole costumed supervillain to show up in the first season of ''WesternAnimation/HitMonkey'' is Lady Bullseye, who is an enemy of Comicbook/{{Daredevil}} in the comics.
* ''WesternAnimation/HulkAndTheAgentsOfSMASH'' has put the Hulks up against Annihilus, Blastaar, and Ego, the Living Planet, all longtime ''Comicbook/FantasticFour'' headaches, and Doctor Doom above especially. Bonus points for ''ComicBook/XMen'' foe Sauron. However, TheManBehindTheMan villain of the series is the Leader, who ''is'' a Hulk villain.

* The Mad Thinker and Awesome Android pop up in ''WesternAnimation/IronManArmoredAdventures'' as enemies (and classmates) of Tony and his buddies. In the comics, they're traditionally enemies of the Comicbook/FantasticFour, even in the ComicBook/UltimateMarvel universe (which the show went with, depicting the Mad Thinker as a [[AgeLift teenaged]] [[GenderFlip girl]], instead of an adult man like the original). And then there's ComicBook/DoctorDoom and ComicBook/{{Magneto}}, who both show up in Season 2 (Magneto's appearance, in fairness, also features Professor X and Jean Grey, both of whom were from the X-Men).

* The ''WesternAnimation/SpiderWoman'' episode "Realm of Darkness" had Spider-Woman fight Dormammu, who was traditionally an enemy of Comicbook/DoctorStrange.
* Taken to the extreme in ''WesternAnimation/UltimateSpiderMan'', as part of the show's apparent attempt to be as different as possible to the traditional Spider-Man formula. So far, the show has largely avoided classic Spider-Man antagonists, the only ones showing up after more than ''twenty'' episodes being ComicBook/{{Venom}} ([[spoiler:with Harry Osborn as the host instead of Eddie Brock, though the symbiote later goes to Flash Thompson and turn him into Agent Venom as it does in the comics]]), ComicBook/DoctorOctopus, ComicBook/NormanOsborn (who doesn't become the Green Goblin until the ''season finale'') and Sandman. The other episodes involve either crossover episodes with other heroes involving villains from the guest-star's rogue gallery (Living Laser for Comicbook/IronMan, Loki for [[Comicbook/TheMightyThor Thor]], Zzzax for [[Comicbook/IncredibleHulk Hulk]], Mesmero and Comicbook/{{Sabretooth}} for ComicBook/{{Wolverine}}) or villains from other Rogues Galleries who are treated like they were Spider-Man's regular villains (Doctor Doom and the Frightful Four, whom are Fantastic Four villains, Batroc the Leaper, whom is a Captain America villain, ComicBook/{{Taskmaster}}, who debuted as an Avengers villain, Whirlwind, originally a foe of Ant-Man, the ComicBook/{{Juggernaut|MarvelComics}} (though justified in that there was one notable comic story where Spider-Man did fight Juggernaut)...) As an added twist, some of Spider-Man's foes are now tied to other heroes, such as Kraven being the one who killed ComicBook/WhiteTiger's father, and the Scorpion being from the same mythical city as Comicbook/IronFist. Even though the show did eventually bring in more Spider-Man rogues and storylines, the aforementioned Taskmaster becomes TheHeavy in the first half of season 3, where he recruits potential new SHIELD heroes [[spoiler:to spring Green Goblin from prison, leading to Goblin's travels across the Spider-Verse]], and in season 4, ComicBook/{{HYDRA}} and its leader Arnim Zola, both foes of Captain America and SHIELD (the latter being the mentors to Spider-Man and other heroes) begin to back the Sinister Six, and Crossbones, another foe of Cap and SHIELD, [[spoiler:is selected by HYDRA to replace Dr. Curt Connors as the Lizard when Spider-Man successfully cures Connors for good]].

* Other Spidey villains have been known to torment Daredevil from time to time, and vice-versa; the guys practically live next door to each other, so there's a ton of overlap (the Beetle being certainly the most recurring after Kingpin). Inverted with ComicBook/{{Mysterio}} who seems to have not so much transferred to Daredevil's gallery as branched out, via a story that saw Mysterio killed off for a time after trying to break Daredevil (copying what happened in ''ComicBook/DaredevilBornAgain'', only this time it got Daredevil's love interest Karen Page killed), becoming an enemy of both of them. Then he ended up [[ComicBook/SpiderMen switching Spider-Men]]. Electro was prominently considered part of both Spider-Man and Daredevil's galleries at the same time during their early years.[[note]]He actually didn't show up that often at the time, but when he did, he alternated between them.[[/note]] Case in point: The first ''Amazing Spider-Man'' annual had various supervillains Spidey had defeated before gang up, as the Sinister Six, in order to have their revenge on him. When ''Daredevil'' got an annual, too, we saw Electro forming the Emissaries of Evil [[RecycledScript consisting of villains who wanted revenge]] on DD. He later went on to fight a larger variety of heroes before ultimately becoming associated with Spider-Man again, though he is well known for being hired to cause a breakout at the Raft that formed the ComicBook/NewAvengers.

* Thanks to sharing continuity, Marvel's [[ComicBook/GIJoeARealAmericanHeroMarvel G.I. Joe]] series had an entire story arc with [[ComicBook/TheTransformers Megatron]] as the antagonist.

* After Doctor Sun was defeated in ''Comicbook/TheTombOfDracula'' by the joined forces of Dracula and the vampire hunters, he went to antagonize Comicbook/{{Nova}} and the Comicbook/FantasticFour.

** As far as invidual X-Men, She tends to have the most conflict with Rogue (her adopted daughter) Nightcrawler (her biological son) and Wolverine (her former lover).