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* ''Film/TheUnbreakableBoy'': Protagonist Austin has brittle bone disease.
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* ''Series/Ironside2013'': The title character's lower body was paralyzed. He moves around using a wheelchair.
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* ''Film/OperationValkyrie'': Protagonist Claus von Stauffenberg loses a hand and an eye on the North Africa theater of UsefulNotes/WorldWarII.
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* ''VisualNovel/IWaniHugThatGator'': Olivia Halford, the eponymous deuteragonist and [[DisabledLoveInterest love interest]], uses a wheelchair. The story tackles ableism as a key theme, exploring how Olivia's experiences with prejudice and discrimination have shaped the way she views herself and others.
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* ''VisualNovel/IWaniHugThatGator'': Olivia Halford, the eponymous deuteragonist and [[DisabledLoveInterest love interest]], interest, uses a wheelchair. The story tackles ableism as a key theme, exploring how Olivia's experiences with prejudice and discrimination have shaped the way she views herself and others.
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* ''VisualNovel/IWaniHugThatGator'': Olivia Halford, the eponymous deuteragonist, uses a wheelchair. The game tackles ableism as one of its key themes, exploring how discrimination and prejudice (both societal and internalized) have shaped the way Olivia views herself and others.
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* ''VisualNovel/IWaniHugThatGator'': Olivia Halford, the eponymous deuteragonist, deuteragonist and [[DisabledLoveInterest love interest]], uses a wheelchair. The game story tackles ableism as one of its a key themes, theme, exploring how Olivia's experiences with prejudice and discrimination and prejudice (both societal and internalized) have shaped the way Olivia she views herself and others.
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* ''VisualNovel/IWaniHugThatGator'': Olivia Halford, the protagonist's love interest, uses a wheelchair. Ableism is a key theme of the story, and the game explores how Olivia's experiences with discrimination and microaggressions have shaped the way she views herself and others.
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* ''VisualNovel/IWaniHugThatGator'': Olivia Halford, the protagonist's love interest, eponymous deuteragonist, uses a wheelchair. Ableism is a key theme of the story, and the The game explores tackles ableism as one of its key themes, exploring how Olivia's experiences with discrimination and microaggressions prejudice (both societal and internalized) have shaped the way she Olivia views herself and others. others.
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* ''VisualNovel/IWaniHugThatGator'': Olivia Halford, the protagonist's love interest, uses a wheelchair. Ableism is a key theme of the story, and the game explores how Olivia's experiences with discrimination and microaggressions have shaped the way she views herself and others.
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* ''Film/TheTheoryOfEverything'': A biopic of Creator/StephenHawking, who was mostly incapacitated with ALS and used a wheelchair.
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* ''Film/TheTheoryOfEverything'': A biopic of Creator/StephenHawking, who was mostly incapacitated with ALS and used a wheelchair. wheelchair and a synthetic voice generator
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* ''Film/AVeryLongEngagement'': Protagonist Mathilde suffered from polio and has a prominent limp as a result.
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* ''Film/AVeryLongEngagement'': Protagonist Mathilde suffered from polio and has a prominent limp as a result. She uses a wheelchair sometimes.
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* ''Film/WildWildWest'': BigBad Dr. Arliss Loveless [[HalfTheManHeUsedToBe lost his bottom half in an explosive-filled accident]].
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* ''Film/WildWildWest'': BigBad Dr. Arliss Loveless [[HalfTheManHeUsedToBe lost his bottom half half]] in an explosive-filled accident]].accident.
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[[folder:Franchises]]
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* ''Franchise/TheHunchbackOfNotreDameDisney'': The protagonist, Quasimodo, is a hunchback with a face that's quite deformed.
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* ''Franchise/TheHunchbackOfNotreDameDisney'': ''DerivativeWorks/TheHunchbackOfNotreDame'': The protagonist, Quasimodo, is a hunchback with a face that's quite deformed.deformed.
** ''Franchise/TheHunchbackOfNotreDameDisney'': The Disney franchise based on the above.
** ''Franchise/TheHunchbackOfNotreDameDisney'': The Disney franchise based on the above.
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* ''Series/Cain2012'': Protagonist Frédéric Caïn is a paraplegic police officer.
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* ''Series/PowerRangersCosmicFury'': The Black Ranger loses his right arm and is grafted an artificial arm by the [[Series/MightyMorphinPowerRangers original]] Blue Ranger.
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* ''Anime/{{Texhnolyze}}'': The main premise of the show is centered around creating {{artificial limb}}s, and whether CyberneticsEatYourSoul is teased a lot.
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* ''Anime/{{Texhnolyze}}'': The main premise of the show is centered around creating {{artificial limb}}s, and whether the possibility of CyberneticsEatYourSoul is teased a lot.lot.
* ''Anime/TheVisionOfEscaflowne'': Recurring antagonist [[HeelFaceTurn and later]] [[EleventhHourRanger ally]] Folken lost his right arm in a coronation ritual gone wrong in the past and is presently donning an artificial arm.
* ''Anime/TheVisionOfEscaflowne'': Recurring antagonist [[HeelFaceTurn and later]] [[EleventhHourRanger ally]] Folken lost his right arm in a coronation ritual gone wrong in the past and is presently donning an artificial arm.
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* ''ComicBook/TheWalkingDead'': Protagonist Rick Grimes loses his right hand during the Prison Arc. Rick would later suffer a leg injury that permanently hinders his walking. Dale gets his left foot severed due to a LifeOrLimbDecision. His remaining leg would later be eaten by cannibals. Rick's mutilator, The Governor, gets LaserGuidedKarma when he loses his right arm, dick, and left eye.
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* ''ComicBook/TheWalkingDead'': Protagonist Rick Grimes loses his right hand during the Prison Arc. Rick Arc, and would later suffer a leg injury that permanently hinders his walking. Dale gets his left foot severed due to a LifeOrLimbDecision. His LifeOrLimbDecision, and his remaining leg would later be eaten by cannibals. Rick's mutilator, The Governor, gets LaserGuidedKarma when he loses his right arm, dick, and left eye.
* ''Film/BoxingHelena'' sees the [[SecondaryCharacterTitle title character]] het her legs amputated by her StalkerWithACrush VillainProtagonist (who is [[DeadlyDoctor a surgeon]]) after a car accident, and later her arms after failing to escape from him. [[AllJustADream At least]] until the TwistEnding.
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* ''Series/TheWalkingDead2010'': LiveActionAdaptation of ''ComicBook/TheWalkingDead''. It shuffled many character disabilities in canon (which will be too long to put here). Notably, Protagonist Rick Grimes [[AbledInTheAdaptation was spared from both his canonical handicaps]].
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* ''Series/TheWalkingDead2010'': LiveActionAdaptation of ''ComicBook/TheWalkingDead''. It shuffled many character disabilities in canon (which will be too long to put here). Notably, Protagonist Rick Grimes was initially [[AbledInTheAdaptation was spared from both his canonical handicaps]].handicaps]].
** ''Series/TheWalkingDeadTheOnesWhoLive'': The sixth SpinOff of [[Franchise/TheWalkingDeadTelevisionUniverse the TV franchise]], it shows Rick finally losing a hand (though his left one), but still never gets the permanent leg injury (yet).
** ''Series/TheWalkingDeadTheOnesWhoLive'': The sixth SpinOff of [[Franchise/TheWalkingDeadTelevisionUniverse the TV franchise]], it shows Rick finally losing a hand (though his left one), but still never gets the permanent leg injury (yet).
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** ''VideoGame/MetalGearSolid2SonsOfLiberty'': Main antagonist Solidus Snake loses his left eye midway through the game.
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** ''VideoGame/MetalGearSolid2SonsOfLiberty'': Main antagonist Solidus Snake loses his left eye midway through the game. Ocelot's right hand replacement plays a key factor in the game's climax.
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* ''VideoGame/WildArms1'': Protagonist Rudy Roughnight chops off (blows off in the VideoGameRemake) his left arm in a LifeOrLimbDecision midway through the story and was later grafted with a mechanical arm.
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** ''WesternAnimation/GoodWiltHunting'':A flashback in this movie reveals that [[spoiler:he obtained his injuries while saving his creator from a grievous injury during a basketball game]].
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** ''WesternAnimation/GoodWiltHunting'':A ''WesternAnimation/GoodWiltHunting'': A flashback in this movie reveals that [[spoiler:he obtained his injuries while saving his creator from a grievous injury during a basketball game]].
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* ''WesternAnimation/FostersHomeForImaginaryFriends'': Wilt is missing his left arm and has a broken left eye. A flashback in a [[WesternAnimation/GoodWiltHunting movie]] reveals that [[spoiler:he lost them while saving his creator from a grievous injury during a basketball game]].
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* ''WesternAnimation/FostersHomeForImaginaryFriends'': Wilt is missing his left arm and has a broken left eye. A
** ''WesternAnimation/GoodWiltHunting'':A flashback ina [[WesternAnimation/GoodWiltHunting movie]] this movie reveals that [[spoiler:he lost them obtained his injuries while saving his creator from a grievous injury during a basketball game]].
** ''WesternAnimation/GoodWiltHunting'':A flashback in
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* ''Franchise/StarWars'': Protagonists Anakin and Luke Skywalker have ArtificialLimbs (Anakin [[ForegoneConclusion eventually]] becomes a full-fledged {{Cyborg}}).
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*** ''Anime/MobileSuitGundamSEEDDestiny'': Waltfield now sports a prosthetic arm [[ArmCannon that secretly holds a shotgun]]. TheLeader of the three DOM pilots who later joins Kira's party is missing her right eye, though she isn't really an important character like Waltfield.
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*** ''Anime/MobileSuitGundamSEEDDestiny'': Waltfield now sports a prosthetic arm [[ArmCannon that secretly holds a shotgun]]. Hilda Harken, TheLeader of the three DOM pilots who later joins Kira's party party, is missing her right eye, eye though she isn't really an important character like Waltfield.
* ''Anime/FinalFantasyVIIAdventChildren'': Sequel to the video game ''VideoGame/FinalFantasyVII'' (see below). An epidemic that causes physical deterioration is the film's main premise, which affected major characters including main protagonist Cloud Strife, reformed antagonist Rufus Shinra, and new character Denzel. The one-armed Barrett Wallace and the one-eyed Red XIII appear in the climactic battle.
* ''Anime/MobileSuitGundamSEEDFreedom'': The one-eyed Hilda Harken [[AscendedExtra is now]] an important supporting character.
* ''Manga/NausicaaOfTheValleyOfTheWind'': Antagonist Kushana is missing an arm and probably legs replaced with armor-like ArtificialLimbs.
* ''Manga/NausicaaOfTheValleyOfTheWind'': Antagonist Kushana is missing an arm and probably legs replaced with armor-like ArtificialLimbs.
* ''Film/TheIronClaw'': A BioPic about the Wrestling/VonErichFamily which includes Kerry Von Erich, a wrestler who had his right foot amputated and secretly wrestled with a prosthetic until he was DrivenToSuicide.
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** ''Film/IronMan2'': The movie features said magnetic device becoming obsolete which starts taking a toll on Tony's health. His StoryArc revolves around him needing to update it.
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** ''Film/IronMan2'': The movie features said magnetic device becoming obsolete which starts taking a toll on Tony's health. His Part of his StoryArc revolves around him needing to update it.
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*** ''VideoGame/FinalFantasyVIIRemake'': Its remake and StealthSequel.
*** ''VideoGame/FinalFantasyVIIRebirth'': Sequel of ''Remake''.
*** ''VideoGame/FinalFantasyVIIRebirth'': Sequel of ''Remake''.
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** ''Film/DeadpoolAndWolverine'': Deadpool looks like a burn victim.
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* ''Series/Echo2024'': Protagonist Maya has a prosthetic due to losing her leg in the car accident which killed her mother as a child. It doesn't stop her from being skilled in unarmed combat (including kicking her opponents frequently) so her prosthetic may be special. This was added to the character (who's only deaf) since actress Creator/AlaquaCox [[DisabledCharacterDisabledActor really has a prosthetic leg]]. It got less focus in ''Series/Hawkeye2021'', where Maya is introduced.
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* ''Series/Echo2024'': Protagonist Maya has a prosthetic due to losing her leg in the car accident which killed her mother as a child. It doesn't stop her from being skilled in unarmed combat (including kicking her opponents frequently) so her prosthetic may be special. This was added to the character (who's only deaf) originally just deaf in the comics) since actress Creator/AlaquaCox [[DisabledCharacterDisabledActor really has a prosthetic leg]]. It got less focus in ''Series/Hawkeye2021'', where Maya is introduced.
