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[[folder:Film]]

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[[folder:Film]][[folder:Comic Books]]
* ''ComicBook/BlueWraith'': [[spoiler:Danarius' sarcophagus]] is designed to work on elves. Putting a human into it seems to give them a ''lot'' more of the same powers that Fenris has ... but also turns them into a ticking bomb that explodes in a blast of lyrium within minutes. The villains are able to exploit this effect by sending a small squad of exploding mooks after the protagonists, as well as the qunari trying to capture the sarcophagus. While they fail at killing any of the heroes, the exploding Tevinters do completely wipe out all the qunari, including the new Viddasala.
* In ''Franchise/{{Superman}}'' storyline ''ComicBook/AMindSwitchInTime'', supervillain Euphor gets more and more powerful as he absorbs more negative emotions until he is able to fight Superman face-to-face. Superman beats him by feeding him his negative emotions caused by Krypton's destruction until Euphor becomes frozen into a cocoon of solid energy.
[[/folder]]

[[folder:Film -- Animated]]



%%* This is how the BigBad is defeated in the second ''WesternAnimation/{{Hoodwinked}}'' movie.
[[/folder]]

[[folder:Film -- Live-Action]]



%%* This is how the BigBad is defeated in the second ''WesternAnimation/{{Hoodwinked}}'' movie.



* The Literature/MagicTheGathering novel ''Time Spiral'', Radha uses this to defeat Greht. She breaks his hold on his horde, he gets it back by starting a ridiculously powerful spell, and Radha starts feeding him more mana. This doesn't end well for him.

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* The Literature/MagicTheGathering ''Literature/MagicTheGathering'' novel ''Time Spiral'', Radha uses this to defeat Greht. She breaks his hold on his horde, he gets it back by starting a ridiculously powerful spell, and Radha starts feeding him more mana. This doesn't end well for him.
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* In one of the future's in ''Film/XMenDaysOfFuturePast'', three different Sentinels overload Bishop with too much energy to absorb, causing him to explode into a fireball.

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* In one of the future's futures in ''Film/XMenDaysOfFuturePast'', three different Sentinels overload Bishop with too much energy to absorb, causing him to explode into a fireball.
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Added commentary for Stargate.

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* ''Series/StargateSG1'' has an episode where Daniel Jackson learns to use the [[ResetButton sarcophagus]] for reasons other than coming BackFromTheDead. He starts to become DrunkWithPower before the team brings him back to the base, where he goes through painful [[NailedToTheWagon withdrawal symptoms]].

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* In the ''WesternAnimation/BatmanTheAnimatedSeries'' episode featuring Bane, Batman defeats Bane by sabotaging his Venom pump, causing a massive overdose. This is repeated in two ''WesternAnimation/BatmanBeyond'' episodes: in one episode, "The Winning Edge", Bane's doctor adapts the venom formula into slap-on dermal patches, only to be defeated when Terry knocks him into an entire box of them (followed by an explosion to knock him out); in another episode, "Splicers", a scientist marketing LegoGenetics to create animal people [[OneWingedAngel turns himself into a chimera]] to fight Batman, only to be defeated when Batman doses him with even more of the stuff, causing him to go turn into a [[BodyHorror horrible blob monster]] that [[WhatMeasureIsANonHuman can safely be blown apart on a Saturday morning cartoon]].

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* ''WesternAnimation/BatmanTheAnimatedSeries'':
**
In "Feat of Clay", two of Roland Daggett's goons catch Matt Hagen trying to steal enough Renuyu to continue concealing his facial disfigurement. They force-feed him a large quantity of the ''WesternAnimation/BatmanTheAnimatedSeries'' episode featuring Bane, stuff, intending to kill him but instead transforming him into Clayface.
** In "Bane",
Batman defeats Bane by sabotaging his Venom pump, causing a massive overdose. This is repeated in two ''WesternAnimation/BatmanBeyond'' episodes: in one episode, overdose.
* ''WesternAnimation/BatmanBeyond'':
** In
"The Winning Edge", Bane's doctor adapts the venom Venom formula into slap-on dermal patches, patches for an illicit drug trade, only to be defeated when Terry knocks him into an entire box of them (followed by an explosion to knock him out); in another episode, out).
** In
"Splicers", a scientist marketing LegoGenetics to create animal people [[OneWingedAngel turns himself into a chimera]] to fight Batman, only to be defeated when Batman doses him with even more of the stuff, causing him to go turn into a [[BodyHorror horrible blob monster]] that [[WhatMeasureIsANonHuman can safely be blown apart on a Saturday morning cartoon]].
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* The MagicTheGathering novel ''Time Spiral'', Radha uses this to defeat Greht. She breaks his hold on his horde, he gets it back by starting a ridiculously powerful spell, and Radha starts feeding him more mana. This doesn't end well for him.

to:

* The MagicTheGathering Literature/MagicTheGathering novel ''Time Spiral'', Radha uses this to defeat Greht. She breaks his hold on his horde, he gets it back by starting a ridiculously powerful spell, and Radha starts feeding him more mana. This doesn't end well for him.
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Corrected a typo.


* Played with in ''{{VideoGame/TAGAP}}''. Normally, the titular drug allows increased combat prowess and regenerative capabilities, at the cost of lower intelligence and higher vulnaribility to brainwashing; however, protagonist Pablo has been altered to resist the drug's drawbacks while keeping all the benefits. It's still possible for him to temporarily "overdose" on the pill, but this just results in a mild MushroomSamba and a very useful BulletTime.

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* Played with in ''{{VideoGame/TAGAP}}''. Normally, the titular drug allows increased combat prowess and regenerative capabilities, at the cost of lower intelligence and higher vulnaribility vulnerability to brainwashing; however, protagonist Pablo has been altered to resist the drug's drawbacks while keeping all the benefits. It's still possible for him to temporarily "overdose" on the pill, but this just results in a mild MushroomSamba and a very useful BulletTime.
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* ''Series/StarTrekTheNextGeneration'' had an episode ("Too Short a Season") where an old diplomat takes his wife's share of age-reversing medication as well as his own.

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* ''Series/StarTrekTheNextGeneration'' had an episode ("Too Short a Season") where an old diplomat a retired InsaneAdmiral takes his wife's share of age-reversing medication as well as his own.own. He de-ages so quickly that all his bodily systems become totally unstable, and he dies.
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** The second game, however, plays this straight. When Pablo is exposed to a TAGAP-infused rainfall, the drug is too much even for him: he starts suffering from extreme euphoria and hallucinations, and visibly struggles to stay sane. Luckily, the effects quickly recede after he finds shelter.
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* In ''Series/TheOuterLimits1995'' episode "Last Supper", a scientist pursues an immortal woman to unlock the secret of eternal life. He injected a tiny bit of her blood into a rat, which was still alive decades later. As his age had caught up with him, he decided to attempt the same on himself. He drew a little too much blood, however, causing him to de-age into a pre-fetal puddle of human tissue.

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* In ''Series/TheOuterLimits1995'' episode "Last Supper", "[[Recap/TheOuterLimits1995S3E4LastSupper Last Supper]]", a scientist pursues an immortal woman to unlock the secret of eternal life. He injected a tiny bit of her blood into a rat, which was still alive decades later. As his age had caught up with him, he decided to attempt the same on himself. He drew a little too much blood, however, causing him to de-age into a pre-fetal puddle of human tissue.
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* In ''Webcomic/GirlGenius'' [[McNinja Smoke Knights]] use [[PsychoSerum combat stimulants they call "MoveIt"]]. The highest level Violetta [[http://www.girlgeniusonline.com/comic.php?date=20090211 dared to use on a wounded Tarvek]] was #6, which him run around as new...but as a side effect it made a person that's normally a [[MagnificentBastard subtle schemer]] act [[SuicidalOverconfidence suicidally "heroic"]]. And he didn't look pretty when this stuff wore out. Then [[spoiler:Zola]] drank a dose of #11. That level can be lethal for unprepared people as it is, so Violetta decided she'd have a better chance injecting [[spoiler:Zola]] with an overdose rather than trying any other poisons.

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* In ''Webcomic/GirlGenius'' [[McNinja Smoke Knights]] use [[PsychoSerum combat stimulants they call "MoveIt"]]. The highest level Violetta [[http://www.girlgeniusonline.com/comic.php?date=20090211 dared to use on a wounded Tarvek]] was #6, which him run around as new...but as a side effect it made a person that's normally a [[MagnificentBastard subtle schemer]] act [[SuicidalOverconfidence suicidally "heroic"]]. And he didn't look pretty when this stuff wore out. Then [[spoiler:Zola]] drank a dose of #11. That level can be lethal for unprepared people as it is, so Violetta decided she'd have a better chance injecting [[spoiler:Zola]] with an overdose [[http://www.girlgeniusonline.com/comic.php?date=20101029#.W9xHrSdReCU overdose]] rather than trying any other poisons.
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* In ''Series/KamenRiderBuild'', everyone is assigned a Hazard Level, which is the level of Nebula Gas that their body can safely intake. Most normal humans become [[MonsterOfTheWeek Smash]] when exposed to high concentrations of Nebula Gas, while those with higher Hazard Levels (read: most of the main cast) retain their human forms and can become Kamen Riders (or use similar systems such as the Transteam Gun). However, at higher concentrations, Nebula Gas is a PsychoSerum, which drives the user berserk if they don't have a strong enough will, and even if you can resist it, being infused with Nebula Gas beyond what your body can naturally intake carries the risk of dying if you're defeated and your transformation cancels.
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** ForgottenRealms had a few. Too many strong spells released at once tend to interact abnormally until they form one "spell-storm" on the scale up to FantasticNuke or overload and warp [[TheForce the Weave]] powering them. This way several civil wars among the Drow caused total destruction of their cities, supposedly including the creation of Great Rift -- geographical feature about 170 miles long and 1000 feet deep. [[http://www.wizards.com/default.asp?x=dnd/rl/20060628a Myth Drannor had]] large [[BiggerOnTheInside extradimensional pockets]] built too densely -- enough that they began to interfere, distort magic all around and compromised an originally impenetrable city-scale teleport denial ward -- which becomes Very Bad News during an attack by [[TheLegionsOfHell a whole army of fiends]].

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** ForgottenRealms TabletopGame/ForgottenRealms had a few. Too many strong spells released at once tend to interact abnormally until they form one "spell-storm" on the scale up to FantasticNuke or overload and warp [[TheForce the Weave]] powering them. This way several civil wars among the Drow caused total destruction of their cities, supposedly including the creation of Great Rift -- geographical feature about 170 miles long and 1000 feet deep. [[http://www.wizards.com/default.asp?x=dnd/rl/20060628a Myth Drannor had]] large [[BiggerOnTheInside extradimensional pockets]] built too densely -- enough that they began to interfere, distort magic all around and compromised an originally impenetrable city-scale teleport denial ward -- which becomes Very Bad News during an attack by [[TheLegionsOfHell a whole army of fiends]].
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Added an example of the trope

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* In Literature/{{She}}, Ayesha made herself immortal centuries ago by passing through a magical flame. When she wants her present-day lover to join her in immortality she tries to show him the flame is harmless by passing through it again, something she hadn’t done since the first time. [[spoiler: It turns out even after centuries, a second dose is one too many.]]
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Typo fix


* A gameplay example in the VideoGame/MetalSlug serie: being hit by certain substances will cause your character to transform into a mummy, zombie or ape, the latter two having some advantages (such as subverting OneHitPointWonder and being able to climb on railings). A second dose is however fatal.

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* A gameplay example in the VideoGame/MetalSlug serie: series: being hit by certain substances will cause your character to transform into a mummy, zombie or ape, the latter two having some advantages (such as subverting OneHitPointWonder and being able to climb on railings). A second dose is however fatal.
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None

Added DiffLines:

* Played with in ''{{VideoGame/TAGAP}}''. Normally, the titular drug allows increased combat prowess and regenerative capabilities, at the cost of lower intelligence and higher vulnaribility to brainwashing; however, protagonist Pablo has been altered to resist the drug's drawbacks while keeping all the benefits. It's still possible for him to temporarily "overdose" on the pill, but this just results in a mild MushroomSamba and a very useful BulletTime.
Is there an issue? Send a MessageReason:
None

Added DiffLines:

* In one of the future's in ''Film/XMenDaysOfFuturePast'', three different Sentinels overload Bishop with too much energy to absorb, causing him to explode into a fireball.
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None

Added DiffLines:

** In ''Videogame/DarkSoulsIII'' ''The Ringed City'' we learn more about the Abyss and its connection to humanity. [[spoiler:Humans are only having trouble handling it because of Gwyn placing a seal of fire on humanity that prevented them from properly channeling the Abyss's power through the Dark Soul.]]
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* In ''TheWitcher'', you suffer poisoning when you drink potions. This prevents you from taking too many powerups at once. A justified trope since they ''are'' poisons, many of which are lethal to non-mutated humans, but not to the resistant [[SuperSoldiers Witchers]].

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* In ''TheWitcher'', ''VideoGame/TheWitcher'', you suffer poisoning when you drink potions. This prevents you from taking too many powerups at once. A justified trope since they ''are'' poisons, many of which are lethal to non-mutated humans, but not to the resistant [[SuperSoldiers Witchers]].
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* On ''{{Hero 108}}'', Mystique Sonia can grow [[PowerUpFood magic bean buns]] that give the consumer super strength, but in the episode "Lion Castle" she ate too many and just ended up fat and out of shape.

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* On ''{{Hero ''WesternAnimation/{{Hero 108}}'', Mystique Sonia can grow [[PowerUpFood magic bean buns]] that give the consumer super strength, but in the episode "Lion Castle" she ate too many and just ended up fat and out of shape.
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%% * In one ''FantasyIsland'' a woman was given a potion to become beautiful for a time (an hour??) if she took one drop. Complications ensued and she was forcibly made to drink the whole bottle on the grounds that "if one drop is good the whole bottle is better!" She became a harridan.

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%% * In one ''FantasyIsland'' ''Series/FantasyIsland'' a woman was given a potion to become beautiful for a time (an hour??) if she took one drop. Complications ensued and she was forcibly made to drink the whole bottle on the grounds that "if one drop is good the whole bottle is better!" She became a harridan.
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* While the ''MetroidPrime'' series has the already ToxicPhlebotinum Phazon, ''Corruption'' gives Samus a way to harness it as [[SuperMode Hypermode]]. If Samus is exposed to large amounts of Phazon or she stays in Hypermode for too long, it overloads and she must dump all of the Phazon in the system or she will [[NonstandardGameOver turn into another]] [[EvilTwin Dark Samus]].

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* While the ''MetroidPrime'' ''VideoGame/{{Metroid Prime|Trilogy}}'' series has the already ToxicPhlebotinum Phazon, ''Corruption'' gives Samus a way to harness it as [[SuperMode Hypermode]]. If Samus is exposed to large amounts of Phazon or she stays in Hypermode for too long, it overloads and she must dump all of the Phazon in the system or she will [[NonstandardGameOver turn into another]] [[EvilTwin Dark Samus]].
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** ''TabletopGame/{{Shadowrun}}'': lowers Essence, losing too much causes death
** ''TabletopGame/{{Cyberpunk}} 2020'': lowers Humanity, losing too much causes Cyberpsychosis

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** ''TabletopGame/{{Shadowrun}}'': lowers Getting cyberware and bioware installed damages Essence, losing which is essentially the connection of the body to the soul. While higher grade 'ware can dramatically reduce the impact, having too low essence can, but not always, result in sociopathic tendencies, cyberpsychosis, dissociation, personality loss, and other physical maladies like becoming resistant to cloned replacement parts and picking up a laundry list of allergies along the way. Essence also provides a solid cap on how much causes death
modification somebody can take: if Essence reaches zero for whatever reason, the person in question dies.
** ''TabletopGame/{{Cyberpunk}} 2020'': lowers Humanity, losing too much causes CyberpsychosisCyberpsychosis.
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* ''Series/StarTrekTheNextGeneration'' had an episode where an old diplomat takes his wife's share of age-reversing medication as well as his own.

to:

* ''Series/StarTrekTheNextGeneration'' had an episode ("Too Short a Season") where an old diplomat takes his wife's share of age-reversing medication as well as his own.
Is there an issue? Send a MessageReason:
couldn't find a title or even a plot summary fitting that description. Maybe someone else can?


* In one ''FantasyIsland'' a woman was given a potion to become beautiful for a time (an hour??) if she took one drop. Complications ensued and she was forcibly made to drink the whole bottle on the grounds that "if one drop is good the whole bottle is better!" She became a harridan.

to:

%% * In one ''FantasyIsland'' a woman was given a potion to become beautiful for a time (an hour??) if she took one drop. Complications ensued and she was forcibly made to drink the whole bottle on the grounds that "if one drop is good the whole bottle is better!" She became a harridan.
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None

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* In Marc Cabot's novella ''And All His Heart's Desires,'' the Jade Throne, an artifact of the Indian goddess Rati, gives the first worshipper who touches it a small blessing from Rati once per lunar month. When the hero of the story finds it, it hasn't been touched for ''hundreds of years.'' He touches it. Hilarity ensues. (Did we mention that Rati is the Goddess of [[spoiler: Sex]]?)
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ZCE


* This is how the BigBad is defeated in the second {{Hoodwinked}} movie.

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* %%* This is how the BigBad is defeated in the second {{Hoodwinked}} ''WesternAnimation/{{Hoodwinked}}'' movie.
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* A complicated version in ''VideoGame/{{Evolve}}''. Patterson tech gives off minkowski radiation, which is agonizing to monsters. However, with enough exposure monsters can mutate, gaining new abilities and appearances. But if they get too much it comes full circle and kills them. In basic terms, they get hurt by too much phlebotinum ''and'' too little.
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* Spoofed by [[http://www.theonion.com/content/news/sci_fi_writer_attributes this]] [[TheOnion Onion]] article.

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* Spoofed by [[http://www.theonion.com/content/news/sci_fi_writer_attributes this]] [[TheOnion Onion]] Website/TheOnion article.
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* The MagicTheGathering novel Time Spiral, Radha uses this to defeat Greht. She breaks his hold on his horde, he gets if back by starting a ridiculously powerful spell, and Radha starts feeding him more mana. This doesn't end well for him.

to:

* The MagicTheGathering novel Time Spiral, ''Time Spiral'', Radha uses this to defeat Greht. She breaks his hold on his horde, he gets if it back by starting a ridiculously powerful spell, and Radha starts feeding him more mana. This doesn't end well for him.



* Pictured at the top is Bizarro from ''Series/{{Smallville}}'', who reacts in the opposite manner to kryptonite that Clark does. He gains strength from green kryptonite, which depowers and poisons Clark. When exposed to blue kryptonite, which strips Clark of his powers for as long as it's in contact, he gains a massive power boost and explodes.

to:

* Pictured at the top is Bizarro from ''Series/{{Smallville}}'', who reacts in the opposite manner to kryptonite that than Clark does. He gains strength from green kryptonite, which depowers and poisons Clark. When exposed to blue kryptonite, which strips Clark of his powers for as long as it's in contact, he gains a massive power boost and explodes.

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