History Main / HybridsAreACrapshoot

* The ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' fanfic ''[[https://www.fimfiction.net/story/19341/alicorn Alicorn]]'' explains that alicorns are born with just wings, and then grow a horn in a quick but painful process known as Unity in their first few months of life. Celestia's daughter with an unnamed Earth Pony, Aurora, was born with wings but did not grow a horn and it was assumed that she was born a regular pegasus. After 17 years, however, Aurora, now going by Rainbow Dash, grows a horn (proportionate to her adult body) in an ''excruciatingly'' painful process that lasts an entire week. Celestia believes the delayed maturing is because Rainbow is only a quarter alicorn.

* ''Manga/MyHeroAcademia'': [[spoiler:Dabi]] inherited a much stronger version of his father's fire powers. However, he inherited his mother's constitution, making him resistant to ice but weak to heat. So every time he uses his powers, he risks severely injuring himself, and when we first meet him, much of his flesh is falling off.

* The ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' fanfic ''[[https://www.fimfiction.net/story/19341/alicorn Alicorn]]'' explains that alicorns are born with just wings, and then grow a horn in a quick but painful process known as Unity in their first few months of life. Rainbow Dash, on the other hand, grows a horn as an adult, which takes a whole week and is ''excruciatingly'' painful because she's growing a horn proportionate to her body, which is of course much larger than a newborn. Her mother, Princess Celestia, attributes this delayed maturing to Rainbow being only a quarter alicorn.

* The ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' fanfic ''[[https://www.fimfiction.net/story/19341/alicorn Alicorn]]'' explains that alicorns are born with just wings, and then grow a horn in a quick but painful process known as Unity in their first few months of life. Rainbow Dash, on the other hand, grows a horn as an adult, which takes a whole week and is ''excruciatingly'' painful because she's growing a horn proportionate to her body, which is of course much larger than a typical filly. Her mother, Princess Celestia, attributes this delayed maturing to Rainbow being only a quarter alicorn.

** ''Film/JurassicWorldFallenKingdom'' The Indoraptor is the I. Rex taken to obscene levels. Possibly one of the most dangerous dinosaurs in the franchise, it relentlessly chases and stalks its prey throughout the entire last third of the movie, while being more sadistic and intelligent then the Indominus.

** In one cutaway gag, Kermit the Frog and Miss Piggy have children which are suffering abominations begging for death.

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* ''Fanfic/AbraxasHrodvitnon'': In this ''Franchise/{{Godzilla}}'' Franchise/MonsterVerse fanfiction, it turns out that Ghidorah's DNA doesn't mix well with human DNA. Initial experiments which fuse Ghidorah's DNA to humans end up creating a chaotic UndeadAbomination before the process is refined to create [[spoiler:the Zmeyevich]]. Even Monster X, which is technically created by a Ghidorah head doing the merging himself rather than relying on human experiments, is initially a BodyHorror-crippled monstrosity with the inverted form of PowerIncontinence [[spoiler:(it gets better)]].

* There exists a ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' fanverse titled [[https://www.deviantart.com/starryoak/gallery/58828968/miracleverse "The Miracleverse"]] with one of the FanCreatedOffspring being a child of Spike (Dragon) and Rarity (Pony), named Miracle. Miracle is extremely sickly and weak, and the doctors weren't even sure if she would survive birth. Averted with the other hybrid children, including the centaur/pony offspring of Iron Will and Fluttershy, and the Dragonequus/Alicorn offspring of Celestia and Discord, which are healthy enough (although this may be likely due to other factors).

* ''Film/JurassicWorld'': The Indominus rex is a genetically modified dinosaur that combines the DNA of multiple species. It is stronger and more violent than other dinosaurs and even kills for sport (although being raised alone while having the raptor's social instincts didn't help).
* ''Film/JurassicWorldFallenKingdom'' The Indoraptor is the I. Rex taken to obscene levels. Possibly one of the most dangerous dinosaurs in the franchise, it relentlessly chases and stalks its prey throughout the entire last third of the movie, while being more sadistic and intelligent then the Indominus.
* ''Film/{{Species}}''. Sil is the product of genetic combination of human and alien DNA. She is a HalfHumanHybrid {{Shapeshifter}} whose base form is BodyHorror. She is compelled to mate with human males (and then kill them) in order to reproduce.

* In ''Series/{{Farscape}}'', major character Scorpius (BigBad in Seasons 2 and 3, ExBigBad TokenEvilTeammate in Season 4) is an experimentally produced hybrid of Sebacean (HumanAliens) and Scarran (DraconicHumanoid). He is a GeniusBruiser, but suffers from assorted painful health problems from the conflicts between his ancestral species - the worst is that he is unable to control his own body temperature and is in danger of dying from heatstroke whenever he exerts himself. As a result, he has to wear a scary-looking coolant suit, which includes a heat sink that is driven through the side of his skull and into his cranial cavity.

* Series/TheXFiles: [[spoiler: Scully's daughter,]] Emily, is an alien-human hybrid. She develops a rare form of anemia and [[spoiler:dies at the end of her two-episode arc.]]

* The Myrmecoleon (a literal ant-lion) starves to death shortly after it is born, due to neither of its halves being able to digest the other's food.

* ''TabletopGame/DarkSun'': The Mul are a magically-created hybrid race that have the stature of a human and the fortitude of a Dwarf. Although they are popular in the arenas and the slave pits, they are completely sterile and more often than not kill their own mother during childbirth.
* ''TabletopGame/LeviathanTheTempest'': Hybrids are required to take one or more Genetic Conditions to represent the side effects of their inhuman heritage, these can be anything from sterility to having a fish-tail instead of legs. Lahmassu (Hybrids who derive their inhuman ancestry from only a single Strain of Leviathan) are somewhat more stable and take fewer conditions.
* While it's seemingly blanketly impossible in the [[TabletopGame/ChroniclesOfDarkness new]], in ''[[TabletopGame/OldWorldOfDarkness The Old World Of Darkness]]'' it is technically possible, if very hard, to make a werecreature-vampire. However, it's a ''very'' bad idea. The exact result depends on the breed, but the ''best case'' scenario is "psychologically broken abomination". The less good results include "feral monster in [[UnstoppableRage constant frenzy"]], "being that spontaneously bursts into flames in 24 hours or even immediately" or, perhaps worst of all, [[AndIMustScream "fully conscious rotting corpse"]].

[[folder:Toys]]
* ''ComicBook/BeastWarsUprising:'' The Triple-Threat Masters, a combination of Headmaster, Targetmaster and Powermaster technology which results in a Cybertronian with greatly boosted intelligence, firepower and fuel economy. The downside is that the process drained years off a mech's life. Since one of the two Cybertronians who underwent it was Galvatron, nobody was going to complain that much.

[[/folder]]

* ''Videogame/HeroesOfMightAndMagicAshan'': The wizards of the Silver Cities have conducted various experiments into artificially creating {{Half Human Hybrid}}s and MixAndMatchCritters, with varying degrees of success. One of the most notable failed experiments are the [[SheduAndLammasu Lamasu]], [[BeastWithAHumanFace sphinx-like hybrids of human and manticore]], who have no immunity to the manticore venom in their own bodies - as a result, their bodies are highly unstable and almost all of them die within a short time of being born.
* ''VideoGame/PokemonSwordAndShield'': The Galarian fossil Pokemon (Dracovish, Arctovish, Dracozolt, and Arctozolt) are MixAndMatchCritters that CameBackWrong because they're created by combining incompatible fossil parts of various extinct Pokemon. As a result, their Pokedex entries suffer from a massive case of UnreliableNarrator as they try to claim what their original lives were like in their current states, and their merged body parts have unpleasant side effects to their overall health (like Dracovish having difficulty breathing and Arctozolt perpetually shivering from constant cold exposure).

** In one episode of the original series, Ben accidentally removes the faceplate from the Omnitrix, which results in his aliens being fused together, often with disastrous results, such as a combination of Fourarms and Stinkfly that is much weaker than Fourarms but too heavy to fly.

* ''WesternAnimation/BoyGirlDogCatMouseCheese'': The episode "Cat Confessions" has Mouse revealing that he secretly tried to create a being from the DNA of all the siblings designed to be the perfect family unit. It was a failure, with the resulting abomination inheriting all of their worst traits instead.
* ''[[WesternAnimation/DNAce D.N.Ace]]'': The episode "Tropic Blunder" has Ace deciding to create a Scrammer partially made from a sample of one of Huxley's genetically-engineered plants despite Mendel's warning that doing so would be a bad idea. Sure enough, the created Scrammer has an uncontrollable AxCrazy demeanor and causes chaos all over town with the protagonists trying to figure out a way to stop it.

** The episode "Stewie Is Enceinte" features Stewie giving birth to dog/human hybrids (courtesy of him artificially impregnating himself using Brian's DNA). The resultant hybrids have multiple health issues and genetic abnormalities, such as having a loose bone structure and being deaf.

** The two-part episode "Pinkeye’s Revenge" has Roger Pinkeye inadvertently making a clone of Abby that is also part rat due to contamination of the sample. While the clone proves to be just as skilled and intelligent as the original, the rat DNA gradually starts taking over, mutating her into a giant feral rat.

* ''WesternAnimation/RickAndMorty'': The episode "Ricksy Business" introduces Abradolf Lincler, an entity created by Rick from the DNA of Adolf Hitler and Abraham Lincoln in an attempt to make a morally neutral super leader. It didn't work as planned, as Lincler turned out to be an awkward being of ambiguous moral standings, or in his own words, "an abomination tortured by the duality of his own being."
* ''WesternAnimation/SouthPark'': The episode "Douche and Turd" has a PETA member conceiving a child with an ostrich. Said child is hideously malformed and begging for someone to kill it.

* ''VideoGame/PokemonSwordAndShield'': The Galarian fossil Pokemon (Dracovish, Arctovish, Dracozolt, and Arctozolt) are MixAndMatchCritters that CameBackWrong because they were created by combining incompatible fossil parts of various extinct Pokemon. As a result, their Pokedex entries suffer from a massive case of UnreliableNarrator as it tries to claim what their lives have been in their current states, and their merged body parts have unpleasant side effects to their overall health (like Dracovish having difficulty breathing and Arctozolt perpetually shivering from constant cold exposure).
* ''Videogame/TrialsOfMana'': Two of the protagonists, Kevin and Charlotte, are HalfHumanHybrids, with Kevin being part BeastMan and Charlotte being a half-elf. Their genetics give them significant abilities (impressive strength for Kevin, and ChildProdigy magical abilities for Charlotte), but it also seems to have affected both of their mental development, with Kevin talking extremely informally and often lapsing into BeigeProse, and Charlotte talking in ElmuhFuddSyndwome and having both the body and mindset of a child despite being chronologically fifteen.

* ''Anime/YuGiOh'': To weaken Kaiba's Blue-Eyes Ultimate Dragon, Yugi fused it with his Mammoth Graveyard. Being fused with a Zombie-type caused Blue-Eyes Ultimate to lose ATK every turn by being rotted from the inside. By the time Yugi was ready to destroy it, Blue-Eyes Ultimate Dragon was just a pile of goop in the vague shape of a Dragon.

* ''Manga/DeliciousInDungeon'': [[spoiler:Marcille is revealed to be the daughter of an elf mother and a human father. As a result, her physical and mental development as a child didn’t happen steadily or [[AgeDissonantIndex synchronously]], and she’s unlikely to have children of her own, but on the other hand her health is more robust than any human and her lifespan is expected to exceed even the LongLived elves. Laios compares her, [[InnocentlyInsensitive somewhat insensitively]], to a mule: sterile but superior to either parent. However, that “superiority” is exactly what Marcille fears — if she can outlive elves, that means she’s going to outlive ''all'' her loved ones, too.]]

* ''Film/JurassicWorld'': The Indominus rex is a genetically modified dinosaur that combines the DNA of multiple species. It is stronger and more violent than other dinosaurs and even kills for sport.

* ''Series/StarTrekEnterprise'': Zigzagged in a two-part story arc towards the end of the series. A baby is created from the DNA of Trip (a human) and T'Pol (a [[HumanAliens Vulcan]]) such as that she's essentially their daughter even though T'Pol was never pregnant. Throughout the episodes, the baby has a fever and high white blood cell count [[spoiler:which ultimately kills her]], and other characters wonder if it's because humans and Vulcans have incompatible chromosomes. As it turns out, however, the baby was just created imperfectly; humans and Vulcans are indeed capable of safely interbreeding.

* ''LightNovel/HorizonInTheMiddleOfNowhere'': Elves can live upwards of a thousand years, [[ProportionalAging so they age and mature slowly]]. Half-elves, elf-human hybrids, age mentally at the same rate as elves but physically at the same rate as humans, so most half-elves never develop beyond the mental capacity of children. The few exceptions are more akin to child geniuses than adults.

This is TruthInTelevision. Two different species of animals can sometimes produce offspring if they're similar enough (such as a mule, a cross between a horse and a donkey, or a liger, a lion-tiger hybrid). However, their offspring will ''by definition'' by infertile. The traditional definition of "species" is a set of organisms that are similar enough that they can produce offspring which are themselves capable of reproduction.[[note]]This has come into scrutiny in recent years due to an increased understanding of hybridisation's role in evolution, from cervid species to hominids [[https://en.wikipedia.org/wiki/Sturddlefish to fish separated by over 300 million years]]. Still, it's still true that the average hybrid is infertile, just not ''necessarily'' so.[[/note]]

* In ''Fanfic/TheTwilightMan'', the different physiology between normal humans and the [[Manga/JoJosBizarreAdventure Pillar Men's race]] means that not only are hybrids extremely rare, but they are born DelicateAndSickly and rarely reach to adulthood. [[spoiler:Mary Joestar, despite being taller than even her husband Goerge, was quite frail before her death [[HeroicSacrifice saving her son Jonathan from a carriage accident]]]]. [[SubvertedTrope The same can't be said]] for their [[UnevenHybrid mixed-ancestry descendants]], who have the strength of both races without much in their weakness.

* ''Anime/MyHeroAcademia'': [[spoiler: Dabi]] inherited a much stronger version of his father's fire powers. However, he inherited his mother's resistance to ice. So every time he uses his powers, he risks severely injuring himself, and when we first meet him, much of his flesh is falling off.

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* While it's seemingly blanketly impossible in the [[TabletopGame/ChroniclesOfDarkness new]], in ''[[TabletopGame/OldWorldOfDarkness The Old World Of Darkness]]'' it is technically possible, if very hard, to make a werecreature-vampire. However, it's a ''very'' bad idea. The exact result depends on the breed, but the ''best case'' scenario is "psychologically broken abomination". The less good results include "feral monster in [[UnstoppableRage constant frenzy"]], "being that spontaneously bursts into flames in 24 hours or even immediately" or, perhaps worst of all, [[AndIMustScream "fully conscious rotting corpse"]]. [[/folder]]

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