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* What Akito Sohma did to Kana in ''FruitsBasket''. After Akito blinded Hatori for asking her for permission to marry Kana, she turned against the poor nurse and blamed her so much for Hatori's partial blindness that she drove her mad. It was so bad that Hatori had to delete Kana's memories of their relationship.
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[[folder: Anime and Manga]]
* In ''{{Naruto}}'' Madara's talk with Sasuke about Itachi's true intentions ultimately led to Sasuke becoming AxCrazy and joining Madara's side.
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* The {{Touhou}} FanVid series WebOriginal/KoishiKomeijisHeartThrobbingAdventure uses this as the prime plot driver: SOMETHING is driving all of Gensokyo insane, and the few sane people left ([[AnyoneCanDie well...sane and still living]]) have to figure out who and how to stop it.
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* In {{Euripides}}'s tragedy, ''{{Bacchae}}'', the [[ClassicalMythology god Dionysus]] drives his aunts --and many of the women of Thebes-- mad because they dishonored his mother and refused to acknowledge his divinity. The play ends with [[DownerEnding tragic results]].

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* In {{Euripides}}'s tragedy, ''{{Bacchae}}'', ''Theatre/{{Bacchae}}'', the [[ClassicalMythology god Dionysus]] drives his aunts --and many of the women of Thebes-- mad because they dishonored his mother and refused to acknowledge his divinity. The play ends with [[DownerEnding tragic results]].

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** Accordingly, the Warner Kids of ''{{Animaniacs}}'' almost invariably manage to do this to anyone they have adopted as their "Special Friend" (generally someone who is being a jerk to start with).

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** Accordingly, the Warner Kids of ''{{Animaniacs}}'' ''WesternAnimation/{{Animaniacs}}'' almost invariably manage to do this to anyone they have adopted as their "Special Friend" (generally someone who is being a jerk to start with).



* ''WesternAnimation/SamAndMaxFreelancePolice'': Sam and Max do this to MoralGuardian [[PunnyName Kent Standit]] in "The Glazed MacGuffin Affair". When he banned the titular snack food, Sam and Max went on a crusade to make him lift by getting him to taste one, following him everywhere he went and trying to trick him into eating one. This escalates into a cross-country chase, ending when Kent realizes he's arrived at the factory where Glazed MacGuffins are made and snaps.

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* ''WesternAnimation/SamAndMaxFreelancePolice'': Sam and Max do this to MoralGuardian [[PunnyName Kent Standit]] in "The Glazed MacGuffin Affair". When he banned the titular snack food, Sam and Max went on a crusade to make him lift by getting him to taste one, following him everywhere he went and trying to trick him into eating one. This escalates into a cross-country chase, ending when Kent realizes he's arrived at the factory where Glazed MacGuffins {{MacGuffin}}s are made and snaps.



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<<|MadnessTropes|>>
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* ''MyLittlePonyFriendshipIsMagic'''s Discord favors this as a method of BreakTheCutie.

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* ''MyLittlePonyFriendshipIsMagic'''s ''WesternAnimation/MyLittlePonyFriendshipIsMagic'''s Discord favors this as a method of BreakTheCutie.
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** The Chameleon was '''frightened into a coma'' when he unknowingly built robot duplicates of Peter Parker's dead parents. It ended up being a case of BewareTheNiceOnes.

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** The Chameleon was '''frightened into a coma'' coma''' when he unknowingly built robot duplicates of Peter Parker's dead parents. It ended up being a case of BewareTheNiceOnes.

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* Incidently, SpiderMan is very good at this even if he doesn't entirely mean to do it.
** Kraven was so confounded by Spider-Man's humiliating defeats that he went nuts and eventually committed suicide.
** Electro started off as a typical JerkAss criminal but years of verbal and physical torment had enough of a toll that he is now relegated to asking his mutant girlfriend to shapeshift into Spidey during sex so he could feel in control.
** While Dr. Otopus was driven insane by the accident that turned him into a villain, it has been noted that Spider-Man's constant taunts and beatings drove him farther over the edge. Also, in two separate incidents, he was mentally scarred after pissing Spider-Man off. One of those times involved Spidey ripping his mechanical arms off.
** The Chameleon was '''frightened into a coma'' when he unknowingly built robot duplicates of Peter Parker's dead parents. It ended up being a case of BewareTheNiceOnes.
** Titania of SheHulk fame first fought Spidey back in ''SecretWars'' and instantly acquired a deep fear of Spidey and spiders in general due to the beating/embarrassment she recieved.
** NormanOsborn, like Dr. Octopus, was also already crazy when he first went up against the wall-crawler but after his first defeat, he essentially dedicated his entire life to ruining Peter's. In fact, since he was behind the ''CloneSaga'', it was an inverted case since it mentally broke Peter Parker for about a year or two.
** Spidey drove Eddie Brock (aka Venom) insane by exposing the real identity of a killer after Brock had identitifed an innocent man. This was the only case in which Peter drove someone insane without meeting him.
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* Happens to [[WhiteCollarCrime Warren White]], a white collar criminal who [[OnlySaneMan finds himself in Arkham Asylum]] in the limited series ''Arkham Asylum: Living Hell''. [[HighOctaneNightmareFuel As the story progresses, Warren is continually tortured, abused and terrorized by the other inmates, until finally, he is locked inside Mr Freeze's empty cell by an inmate trying to steal his identity, where he loses his nose, his lips, some of his fingers, and his ears to frostbite.]] Now a "freak" himself, Warren transforms himself into the villain The Great White Shark.
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* This is what the main character of ''Film/TheCube'' has to contend with for the teleplay's entire duration.
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* ''MyLittlePonyFriendshipIsMagic'''s Discord favors this as a method of BreakTheCutie.
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* The Black Spiral Dancers of ''WerewolfTheApocalypse'' force their captives to walk the Black Spiral and go as mad as they have.

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* The Black Spiral Dancers of ''WerewolfTheApocalypse'' ''TabletopGame/WerewolfTheApocalypse'' force their captives to walk the Black Spiral and go as mad as they have.
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** Not to mention the show's ''{{High Octane Nightmare Fuel}}''a.k.a the Reavers, who will occasionally keep one victim alive and force that said victim to watch their shipmates be raped to death, skinned and eaten. The survivor will ultimately go mad from the experience and will only cope by becoming a reaver themselves.

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** Not to mention the show's ''{{High Octane Nightmare Fuel}}''a.k.a the Reavers, who will occasionally keep one victim alive and force that said victim to watch their shipmates be raped to death, skinned and eaten. The survivor will ultimately go mad from the experience and will only cope by becoming a reaver themselves.
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** Not to mention the show's ''{{High Octane Nightmare Fuel}}''a.k.a the Reavers, who will occasionally keep one victim alive and force that said victim to watch their shipmates be raped to death, skinned and eaten. The survivor will ultimately go mad from the experience and will only cope by becoming a reaver themselves.
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* TheNostalgiaChick is usually driven crazy by things in movies she could easily switch off.
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** Arguably not a completely straight case as the goal wasn't to drive her insane, madness being a side-effect from the abuse and what she saw, the point was to enhance her psychic powers. Admittedly the end goal was left in the air and Simon even explains to Book that if the point was just hurting her then they wouldn't want her back.
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* [[CompleteMonster Dr. Prospect]] does this to Daido Katsumi in ''[[KamenRiderDouble W Returns: Eternal]]'' by [[spoiler:slaughtering the entire village he was trying to save and then rubbing salt in the wound by explaining how this happened because [[NiceJobBreakingItHero NEVER took them out of the village in the first place]]. Katsumi ''snaps'' completely as a result.]]
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* ''SamAndMax'' do this to MoralGuardian [[PunnyName Kent Standit]] in "The Glazed MacGuffin Affair." When he banned the titular snack food, Sam and Max went on a crusade to make him lift by getting him to taste one, following him everywhere he went and trying to trick him into eating one. This escalates into a cross-country chase, ending when Kent realizes he's arrived at the factory where Glazed MacGuffins are made and snaps.

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* ''SamAndMax'' ''WesternAnimation/SamAndMaxFreelancePolice'': Sam and Max do this to MoralGuardian [[PunnyName Kent Standit]] in "The Glazed MacGuffin Affair." Affair". When he banned the titular snack food, Sam and Max went on a crusade to make him lift by getting him to taste one, following him everywhere he went and trying to trick him into eating one. This escalates into a cross-country chase, ending when Kent realizes he's arrived at the factory where Glazed MacGuffins are made and snaps.
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* In ''MyNameIsEarl'' the episode "Crazy Witch Lady" has the titular Lady driven to madness by the citizens of Camden treating her like an evil witch. It is implied she was just a regular quirky [[EccentricTownsfolk Camden resident]] before this.
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* [[HalfLife Gordon Freeman]], in ''FreemansMind'', starts to behave more and more erratically as time passes and things happen (not that he wasn't a bit of a CloudCuckooLander to begin with). He has a ''dead serious'' monologue about how he's probably going insane and in need of psychological assistance after it's all over.



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* The film ''Sleep, My Love'' with Claudette Colbert.
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** Unfortunately, a detective who has the misfortune of overseeing Joker being processed through to jail in Batman Confident is indeed driven to madness, ultimately turning into a cop-killing psychopath who ultimately commits suicide when he realizes how Joker turned him into a monster.

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** Unfortunately, a detective who has the misfortune of overseeing Joker being processed through to jail in Batman Confident is indeed driven to madness, ultimately turning into a cop-killing psychopath who ultimately commits suicide when he realizes how Joker turned him into a monster.

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* ''The Screaming Skull'': In which a man attempts to drive his wife insane in order to get unrestrained access to her money.
** It shares [[AdaptationDecay very little]] with the F. Marion Crawford short story of that name besides the title.

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* ''The Screaming Skull'': In which a man attempts to drive his wife insane in order to get unrestrained access to her money.
**
money. It shares [[AdaptationDecay [[InNameOnly very little]] with the F. Marion Crawford short story of that name besides the title.
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* This is the final fate of the protagonists in AlexanderPushkin's ''The Copper Rider'' and ''The Queen of Spades''.
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  • Arguably not a completely straight case as the goal wasn't to drive her insane, madness being a side-effect from the abuse and what she saw, the point was to enhance her psychic powers. Admittedly the end goal was left in the air and Simon even explains to Book that if the point was just hurting her then they wouldn't want her back.

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**Arguably not a completely straight case as the goal wasn't to drive her insane, madness being a side-effect from the abuse and what she saw, the point was to enhance her psychic powers. Admittedly the end goal was left in the air and Simon even explains to Book that if the point was just hurting her then they wouldn't want her back.
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There are many varied reasons for someone to attempt to drive another person to madness. Perhaps they seek to break the character's will in order to make them more pliable, or it may be an attempt to induce a FreakOut or HeelFaceTurn. They may wish to punish the character or torment them by attacking their loved ones in such a fashion. They may try doing so in order to have someone discredited or declared incompetent. [[CompleteMonster Maybe they're]] [[ForTheEvulz just jerks.]]

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There are many varied reasons for someone to attempt to drive another person to madness. Perhaps they seek to break the character's will in order to make them more pliable, or it may be an attempt to induce a FreakOut or HeelFaceTurn. [[RevengeByProxy They may wish to punish the character or torment them by attacking their loved ones in such a fashion.fashion]]. They may try doing so in order to have someone discredited or declared incompetent. [[CompleteMonster Maybe they're]] [[ForTheEvulz just jerks.]]
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* ''SamAndMax'' do this to MoralGuardian [[PunnyName Kent Standit]] in "The Glazed MacGuffin Affair." When he banned the titular snack food, Sam and Max went on a crusade to make him lift by getting him to taste one, following him everywhere he went and trying to trick him into eating one. This escalates into a cross-country chase, ending when Kent realizes he's arrived at the factory where Glazed MacGuffins are made and snaps.

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** The Joker also ''successfully'' drives Harley Quinn nuts in her origin story.

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** The Unfortunately, a detective who has the misfortune of overseeing Joker also ''successfully'' drives being processed through to jail in Batman Confident is indeed driven to madness, ultimately turning into a cop-killing psychopath who ultimately commits suicide when he realizes how Joker turned him into a monster.
***Subverted with
Harley Quinn nuts in Quinn, who was pretty much was insane but functional when she first met the Joker; Joker simply gave her origin story.an excuse to give up control to her crazy side.
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They really do the job better than the gophers.


* Many LooneyTunes characters end up doing this to their antagonists - of particular note are the Goofy Gophers.

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* Many LooneyTunes characters end up doing this to their antagonists - of particular note are the Goofy Gophers.mice Hubie and Bertie.

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