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* ''Film/AWedding1978'': Regina has been addicted to heroin for almost twenty years and has clammy hands, a nervous and distant disposition, and a habit of getting lost in nostalgic tangents.

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* ''Film/AWedding1978'': Regina has been addicted ''Film/TwelveHourShift'': Nurse Mandy is snorting drugs in the middle of her shift and resorts to heroin ''[[OrganTheft stealing organs for almost twenty years and has clammy hands, a nervous and distant disposition, and a habit of getting lost in nostalgic tangents.trafficking ring]]'' to finance her habit.


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* ''Film/AWedding1978'': Regina has been addicted to heroin for almost twenty years and has clammy hands, a nervous and distant disposition, and a habit of getting lost in nostalgic tangents.
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* ''Series/ChappellesShow'': The recurring character Tyrone Biggums was a crackhead whose cocaine addiction made him willing to absolutely debase himself in every way possible so that he could get drugs. In one sketch, he goes on ''Series/FearFactor'' and is absolutely unfazed by the show's challenges, much to the host Creator/JoeRogan's shock, since they were far from the most disgusting things he'd ever done.


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* Music/{{Afroman}}'s "Because I Got High" is a comedy song in which the singer lists off all the ways he screwed up his life because, instead of taking responsibility, he chose to [[TheStoner smoke weed]] instead.
-->''I messed up my entire life because I got high\\
I lost my kids and wife because I got high\\
Now I'm sleeping on the sidewalk and I know why\\
(Why, man?)\\
Because I got high, because I got high, because I got high''
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* Invoked in ''Literature/BlueCore''. The Anell house takes advantage of Void user's proclivity to addictive behavior, due to the inherent quirks of their affinity, to get their Ell sub-branch assassins strung out on drugs. In fact, the first of the Ells Shayma manages to wrest free of their evil grip is a man strung out on an extremely dangerous herb known as Heartroot, and can only think of where he's going to get his next fix. His handler ''actually hides'' the herb in question and then gives it back to him as "reward" for carrying out assassinations. Guiles is so addled, he has to be given the herb so he's clear-headed enough to ''attempt escaping capture'' when Nivir's royal guard, tipped off about an attempt on the entire royal family, comes at him.
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* Discussed in ''[[https://archiveofourown.org/works/42531735 Empty Arms]]''. Slade notes that [[VillainRespect Laurel has a sharp mind]], and that he's grateful she dulled it for the past few months with alcohol, giving everyone else cause to doubt her. After [[spoiler:arranging for him to arrested by the Australian government]], she throws this back in Oliver's face:
-->'''Oliver:''' He might tell them my identity when they question him. Sara’s, too.
-->'''Laurel:''' And what reason would they have to believe him? He’s been high on some drugs for half a decade. As you may recall, the word of an addict isn’t taken all that seriously.
* ''Fanfic/WhatItTakes'': It is indicated that if Quentin was drinking less, he'd be able to recognize that Darhk is a villain. It's also preventing him from doing his job effectively. In Chapter 9, he tries to draw his gun on Laurel (again), only for her to flatly state "You're too drunk to aim".
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* ''Film/AWedding1978'': Regina has been addicted to heroin for almost twenty years and has clammy hands, a nervous and distant disposition, and a habit of getting lost in nostalgic tangents.
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* In ''Film/{{Traffic}}'', Caroline goes from straight-A student to crack whore after she is introduced to freebasing cocaine.

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* In ''Film/{{Traffic}}'', ''Film/Traffic2000'', Caroline goes from straight-A student to crack whore after she is introduced to freebasing cocaine.

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* ''Literature/GoToSleepAJeffTheKillerRewrite'': Randy is an utter mess as an adult drug dealer. He looks aged and has ExhaustedEyebags from the harder drugs he's been taking, his dyed hair is unkempt with the natural roots growing back, and he's spent quite some time in jail.



* ''Literature/YouOnlyLiveTwice'': In this book, Literature/JamesBond is a wreck who can barely keep his job as a 00-agent, going off the rails after [[TheLostLenore Tracy's death]] in ''Literature/OnHerMajestysSecretService'' by [[DrowningMySorrows consuming a lot of booze]] and getting ''multiple hangovers'' on a daily basis.



* Literature/SherlockHolmes is portrayed like this in some pastiches, most notably ''Literature/TheSevenPercentSolution''.

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* %%* Literature/SherlockHolmes is portrayed like this in some pastiches, most notably ''Literature/TheSevenPercentSolution''.''Literature/TheSevenPercentSolution''.
* ''Literature/YouOnlyLiveTwice'': In this book, Literature/JamesBond is a wreck who can barely keep his job as a 00-agent, going off the rails after [[TheLostLenore Tracy's death]] in ''Literature/OnHerMajestysSecretService'' by [[DrowningMySorrows consuming a lot of booze]] and getting ''multiple hangovers'' on a daily basis.
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* In ''ComicBook/{{Cruelty}}'', Reis Northcotte's mother is implied to be this; certainly, she is a MissingMom due to her frequent arrests. His dad takes this to the LogicalExtreme, having [[DisappearedDad died of an overdose]].

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* In ''ComicBook/{{Cruelty}}'', Reis Northcotte's mother is implied to be this; certainly, she is a MissingMom due to her frequent arrests. His dad takes this to the LogicalExtreme, having [[DisappearedDad died of an overdose]]. [[spoiler: In the sequel, his mom dies as well.]]
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[[folder:Web Comics]]

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[[folder:Web Comics]][[folder:Webcomics]]
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* ''Wiki/SCPFoundation'': SCP-1481 is a genie who is utterly useless at granting wishes because he is perpetually stoned out of his mind and addicted to practically every recreational drug imaginable. He typically alternates between begging for more drugs and conjuring up food to satisfy his own munchies (when asked why he doesn't just conjure up drugs for himself too, he broke down in tears, apparently having never thought of this before). During one of his drug-fueled incoherent ramblings, he reveals that [[BenevolentGenie he just wants to grant wishes and make people happy]], but can't, because some {{Jerkass}} wished him into his current state, and then made a ''second'' wish to make the first wish ''irreversible'', purely ForTheEvulz.

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* ''Wiki/SCPFoundation'': ''Website/SCPFoundation'': SCP-1481 is a genie who is utterly useless at granting wishes because he is perpetually stoned out of his mind and addicted to practically every recreational drug imaginable. He typically alternates between begging for more drugs and conjuring up food to satisfy his own munchies (when asked why he doesn't just conjure up drugs for himself too, he broke down in tears, apparently having never thought of this before). During one of his drug-fueled incoherent ramblings, he reveals that [[BenevolentGenie he just wants to grant wishes and make people happy]], but can't, because some {{Jerkass}} wished him into his current state, and then made a ''second'' wish to make the first wish ''irreversible'', purely ForTheEvulz.
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''Choking back, till life gets more thrilling,''\\

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''Choking back, till 'til life gets more thrilling,''\\
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* Tim from ''Film/FragmentOfFear'' is a RecoveredAddict who occasionally sees some of his old friends, including a miserable-looking junkie shooting up in an alley while curious teenager watch him from the street.
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* ''Series/TheFirstLady'': Betty Ford is increasingly affected by her drinking and pill use, having panic attacks that scare her family or flubbing her words in a public speech. Finally they stage an intervention to get her help.
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* In ''Theatre/JasperInDeadland'', Jasper father is a drug addict who's life has clearly been ruined by the addiction. In the song "The Killing", Jasper implies that his father is just waiting to die.
-->''He's a human after a killing''\\
''Filling his days with hope to score.''\\
''Choking back, till life gets more thrilling,''\\
''Chilling his drinks, knowing not who for.''
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* In ''Literature/{{Metaltown}}'', Colin's brother Hayden is addicted to alcohol and drugs, can't hold a job down or find places to stay, and is willing to betray those close to him to get a steady supply.

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* ''Literature/TheElenium'':
** Kragar, one of Martel's minions, is a none-too-bright alcoholic easily controlled with promises of his favorite wine. While the sequel series intially presented him as a FunctionalAddict who had been playing up his addiction, he soon lost his battle with the addiction and by the end of the books had lost his mind and was facing death to liver failure.
** King Wargun is said to have gone insane from drink between the two series and is locked in one wing of the palace at the beginning of the sequel, where he ultimately dies.



* King Wargun and Krager in ''Literature/TheTamuli''. Wargun (who is still sane in ''Literature/TheElenium'') is said to be insane from drink and locked in one wing of the palace at the beginning, and Krager has lost his mind and is dying at the end. It's mentioned that, by the end of ''The Tamuli'', Wargun is dead as well.
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* ''VideoGame/ReKuroi'': [[spoiler:Ether medicine is highly addictive and can give the user magic powers. However, the medicine can drive them mad and turn them into monsters. Worse yet, if the user doesn't keep taking it, they'll run out of ether, lose their powers, and go blind. In Act 11, Asha betrays Kaito and steals the Black Pearl shard in the hopes that it can provide an alternate ether supply to her.]]
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Added entry for El Internado Las Cumbres
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Added entry for El Internado Las Cumbres

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* While many students from ''Series/ElInternadoLasCumbres'' dabble in drugs/alcohol, Eva takes the cake at the school. She is seen huffing spray and by her own description, has a whole pharmacy in her mattress. She is so dependent on pills that at one point, she implores Adèle for assistance because she is no longer able to convince the school doctor to issue her any kind of downers.
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* Dr. Rockzo, the deranged "[[VillainousHarlequin Rock-and-Roll Clown]]" from ''WesternAnimation/{{Metalocalypse}}'', has cocaine addiction as one of his primary character traits. He was once a [[FamedInStory famous rock star]], but has since deteriorated into a drug-addicted mess.
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Knife Nut is now a disambiguation.


* In the ''Manga/BlackLagoon'' story arc involving [[http://en.wikipedia.org/wiki/Abu_Sayyaf Abu Sayyaf]], the Triad enlists as Revy and Rock's chauffeur to the US military base a KnifeNut assassin named Shenhua and a driver named Leigarch who is continuously snorting coke. A previous overdose resulted in frequent hallucinations, and between then and Shenhua's next appearance in the Greenback Jane arc, he apparently OD'd again and wrecked his brain to the point where he had to be institutionalized.

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* In the ''Manga/BlackLagoon'' story arc involving [[http://en.wikipedia.org/wiki/Abu_Sayyaf Abu Sayyaf]], the Triad enlists as Revy and Rock's chauffeur to the US military base a KnifeNut an assassin named Shenhua and a driver named Leigarch who is continuously snorting coke. A previous overdose resulted in frequent hallucinations, and between then and Shenhua's next appearance in the Greenback Jane arc, he apparently OD'd again and wrecked his brain to the point where he had to be institutionalized.
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* In ''VideoGame/FarCry5'', Bliss is a powerfully psychoactive drug that, in addition to its euphoric effects, can be used to condition and brainwash people. While even moderate exposure can be recovered from, long-term, severe addicts are little more than zombies, their higher functions seeming to be completely gone.
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* In 1996, Natalie from ''Series/{{Yellowjackets}}'' drinks and uses drugs but is also an athlete. When she first appears in the pilot episode, set in the current day, she's about to exit rehab (paid by her former teammate Taissa) and not for the first time. When another teammate forcibly prevents her from using cocaine, she resorts to snorting the residue that fell on the carpet.
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* ''Film/AdamAndPaul'' is about two homeless heroin addicts who have lost the ability to care about almost anything except their next fix. They'll do anything for it, including mugging a teenager with Down syndrome, who turns out not to have anything valuable. [[spoiler:When Adam overdoses, Paul takes what's left of the heroin from his jacket pocket.]]
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* ''WesternAnimation/{{Arcane}}'': In the deepest pit of what will one day be [[WretchedHive Zaun]], a colony of addicts to Shimmer live in rags and beg for money. [[spoiler: The incentive of more Shimmer drives Huck, who otherwise wanted to help Vi to repay Vander, to sell her location out to Silco.]]
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* ''Series/{{Hightown}}'': Many characters, including one sad example with the mother of a young baby, are seriously affected due to their alcohol or drug abuse. Jackie herself commits DUI and gets into a car accident. She gets into trouble with the law over it, threatening her career, though usually she's a FunctionalAddict.

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* ''Series/{{Hightown}}'': Many characters, including one sad example with the mother of a young baby, are very seriously affected due to their alcohol or drug abuse. Jackie herself commits DUI and gets into a car accident. She gets into trouble with the law over it, threatening her career, though usually she's a FunctionalAddict.
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* ''Series/{{Hightown}}'': Many characters, including one sad example with the mother of a young baby, are seriously affected due to their alcohol or drug abuse. Jackie herself commits DUI and gets into a car accident. She gets into trouble with the law over it, threatening her career, though usually she's a FunctionalAddict.
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* ''Literature/YouOnlyLiveTwice'': In this book, Literature/JamesBond is a wreck who can barely keep his job as a 00-agent, going off the rails after [[TheLostLenore Tracy's death]] in ''Literature/OnHerMajestysSecretService'' by [[DrowningMySorrows consuming a lot of booze]] and getting ''multiple hangovers'' on a daily basis.

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* Lloyd from ''Film/BloodyMama'' is a morphine addict who seems more or less functional at first, but becomes increasingly dopey and out of it until [[spoiler:he OD's, becoming the first Barker to die]].



* In ''Little Laura and Big John'', very near the end of the film we see that the eponymous Laura has drunk herself stupid after [[spoiler:John's death]].
* Kyle and Dusty in ''Meth Head''. They struggled to find money and suffered some bad side effects from all the meth they snorted.

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* In ''Little Laura and Big John'', ''Film/LittleLauraAndBigJohn'', very near the end of the film we see that the eponymous Laura has drunk herself stupid after [[spoiler:John's death]].
* Kyle and Dusty in ''Meth Head''.''Film/MethHead''. They struggled to find money and suffered some bad side effects from all the meth they snorted.
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** Sarah Lynn is a great example from a TV show about a horse. Her drug addiction spawned from a TraumaCongaLine including the burden of being a [[FormerChildStar child star]] who'd once had dreams outside of that realm, a [[TeenIdol sensation]] [[ThatSoundsFamiliar pop princess]] who was left isolated, strongly implied [[PaedoHunt inappropriate contact]] with her stepfather, [[AntiAdvice horrible advice]] from [=BoJack=] whom she looked to as a [[ParentalSubstitute father figure]] in light of her unexplained DisappearedDad, etc., etc., etc. By the time she was 30, she had become the typical starlet case–druggie whom no one cared for anymore. [[spoiler: She died at only 32 years old after nine months of sobriety due to a heroin overdose.]]

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** Sarah Lynn is a great example from a TV show about a horse. Her drug addiction spawned from a TraumaCongaLine including the burden of being a [[FormerChildStar child star]] who'd once had dreams outside of that realm, a [[TeenIdol sensation]] [[ThatSoundsFamiliar pop princess]] who was left isolated, strongly implied [[PaedoHunt inappropriate contact]] with her stepfather, [[AntiAdvice horrible advice]] from [=BoJack=] whom she looked to as a [[ParentalSubstitute father figure]] in light of her unexplained DisappearedDad, etc., etc., etc. By the time she was 30, she had become the typical starlet case–druggie whom no one cared for anymore. [[spoiler: She died at only 32 31 years old after nine months of sobriety due to a heroin overdose.]]

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