History MadScientist / Comics

* Samantha Argus of ''ComicBook/SafeHavens'' is a personable, enthusiastic grad student who has unlocked the genetic code. She has the power to transform practically any living creature.

* ''ComicBookThe/TransformersAllHailMegatron'' makes Brainstorm into one. He seemingly has no qualms about [[spoiler: putting suggestion ideas inside Kup's mind]] at Prowl's request to exert more control over the army. In ''ComicBook/TheTransformersLastStandOfTheWreckers'' Brainstorm works at the Kimia Facility, an R & D lab full of mad scientists. And Brainstorm in particular is considered especially insane even by ''their'' standards. He makes a hobby of creating weapons so horrible, they're classified as unmentionable by the Ethics Committee. In ''ComicBook/TheTransformersMoreThanMeetsTheEye'' he builds all sorts of weapons [[spoiler: and a holding cell]] for the crew [[spoiler: and to hold Overlord]], including a gun designed to shrink people, a bomb designed to break the fourth wall, an overpowered laser gun labelled My First Blaster (complete with flashing lights and sounds), and a gun that turns Cybertronians into ''Spark-devouring monsters''. Tellingly, when someone asks him about one of his inventions snuffing out a sun, he dismisses it as "filthy, stinking lies"... because they got a small detail wrong. The sun in question did get snuffed out.

** Hugo Strange is the most archetypal mad scientist. He's an expert in everything from chemistry and genetics to psychology, and uses it for evil.

* ''ComicBookThe/TransformersAllHailMegatron'' makes Brainstorm into one. He seemingly has no qualms about [[spoiler: putting suggestion ideas inside Kup's mind]] at Prowl's request to exert more control over the army. In ''ComicBook/TheTransformersLastStandOfTheWreckers'' Brainstorm works at the Kimia Facility, an R & D lab full of mad scientists. And Brainstorm in particular is considered especially insane even by ''their'' standards. He makes a hobby of creating weapons so horrible, they're classified as unmentionable by the Ethics Committee. In ''ComicBook/TheTransformersMoreThanMeetsTheEye'' he builds all sorts of weapons [[spoiler: and a holding cell]] for the crew [[spoiler: and to hold Overlord]], including a gun designed to shrink people, a bomb designed to break the fourth wall, and a overpowered laser gun labelled My First Blaster (complete with flashing lights and sounds). Tellingly, when someone asks him about one of his inventions snuffing out a sun, he dismisses it as "filthy, stinking lies"... because they got a small detail wrong. The sun in question did get snuffed out.

* ComicBook/BladeTheVampireHunter's arch-enemy Deacon Frost was an amoral scientist that performed experiments to gain immortality and upon and injected himself with vampire blood, becoming a unusual type of vampire. He continued to perform his experiments such as producing clones of his victims (one of the special powers he gained) all so he could usurp Dracula's position as Lord of the Vampires.

* Mr. Freeze used to be one of these, with no real backstory, just the whole freezing schtick. Then came ''WesternAnimation/BatmanTheAnimatedSeries'' which gave him [[IncrediblyLamePun chillingly]] tragic backstory and motivation, turning him more into a villainous [[TheWoobie Woobie.]] This new version of the character was {{Retcon}}[[CanonImmigrant ned]] into the main DCU.

* Franchise/{{Batman}} rogue Scarecrow is an expert psychologist who creates fear gas that preys on the target's most deeply seeded phobias.

* Hugo Strange from ''Franchise/{{Batman}}'' is an archetypal mad scientist. He's an expert in everything from chemistry and genetics to psychology, and uses it for evil.

* ''ComicBook/RequiemVampireKnight'' features an ''entire faction'' of these with the Archeologists. They were originally scientists who made disastrous inventions in life, and were damned to become [[{{mummy}} mummy-like beings]] on [[PlanetHeck Résurrection]]. The Archeologists are the only beings allowed [[FantasyGunControl to control human technology]] in order to keep it out of the hands of the lower masses in the setting and the "mad" part comes from the fact they wear [[GenuineHumanHide other people's skin when they come out from their sarcophagus]].

* Escariano Avieso from ''ComicBook/{{Superlopez}}''.

* ''ComicBook/RequiemVampireKnight'' features an ''entire faction of these'' with the Archeologists. They were originally scientists who made disastrous inventions in life, and were damned to become [[{{mummy}} mummy-like beings]] on [[PlanetHeck Résurrection]]. The Archeologists are the only beings allowed [[FantasyGunControl to control human technology]] in the setting and the "mad" part comes from the fact they wear [[GenuineHumanHide other people's skin when they come out from their sarcophagus]].

* In ''YTheLastMan'' geneticist Dr Allison Mann claims she was illegally cloning a nephew who needed a bone transplant. She later admits this story was fictional to gain Agent 355's sympathy rather than be thought of as a 'mad scientist'; her actual motive was to spite her father who was nearing success in cloning the first human. [[spoiler: After several red herrings we discover the REAL mad scientist is in fact Allison's father, who was seeking to clone his daughter so he could be a better parent the next time round, yet who also sabotaged Allison's cloning experiment out of sheer spite and may have accidentally caused the plague that all but wiped out all males.]]

** Is this the same Mandarin who wielded the [[NinjaPirateZombieRobot Ten Rings of Power that were the power source of a spaceship belonging to alien dragons]]? It's like the writers aren't sure if they want him to be an [[EvilOverlord evil sorcerer overlord]], a Mad Scientist, or both.
*** Yes, some of his inventions were adaptations of said aliens' technology. Depending on the writers, the Mandarin has varying levels of superhuman martial arts, too, so he really is some kind of every-villain.
*** The Mandarin is Dr. Frankenstein and Remo Williams in one man.

* {{ComicBook/Spider-Man}}'s ArchEnemy, ComicBook/DoctorOctopus.

** Dr. Mindbender was originally a benevolent orthodontist named Dr. Binder, who in researching ways to alleviate dental pain, used an experimental brainwave device on himself, which turned him twisted and evil. He auditioned for the role of Cobra scientist by creating the [[MechaMooks Battle Android Troopers]] and [[ManEatingPlants creeper vine spores]], and went on to create Serpentor[[note]]though, unlike in the [[WesternAnimation/GIJoeARealAmericanHero cartoon]], Cobra Commander commissioned Mindbender to create a SuperSoldier to serve as a field general, and only later realized too late that Serpentor would have the ambition to usurp the Commander[[/note]]. Mindbender is incredibly vain, usually going shirtless to show off his well-developed pectorals. He was also paranoid enough to [[spoiler: have a clone backup of himself in the event of his own demise, and create mind-control chips for high-ranking Cobra officers that, in conjunction with a Brainwave Scanner treatment, would ensure their loyalty]].

* Dr Mindbender from ''GIJoe'' is particularly mad. Cloner, Genetic Engineer, Robot designer and master of mind control and inventor of many of Cobra's bizarre superweapons. That he's bald, usually shirtless and has pecs like melons only enhances his image of insanity. He even [[spoiler: installed mind control chips in several prominent Cobra members, and prepared for his own death by creating a clone backup]]. Oh, and before he became a mad scientist, he was a... benevolent orthodontist. Until his freak orthodontics accident (seriously).

* The original incarnations of Franchise/{{Superman}}'s archenemy, SelfDemonstrating/LexLuthor. In the years since, he's also been a CorruptCorporateExecutive and a [[PresidentEvil villainous politician]].

* SelfDemonstrating/DoctorDoom is an interesting case, as he is both a MadScientist ''and'' an EvilSorcerer. [[SorcerousOverlord As well as the leader]] [[EmperorScientist of a country]].

* There is a double subversion in ''UniversalWarOne''. [[spoiler: The scientist who invented the wormhole is the only one to care about a possible TimeParadox, so he kills the fools who want to 'go home' even if it endangers the universe. However, when Kalish explains to him there is no way to create a time paradox, the scientist becomes mad.]]

* ''ComicBookThe/TransformersAllHailMegatron'' makes Brainstorm into one. He seemingly has no qualms about [[spoiler: putting suggestion ideas inside Kup's mind]] at Prowl's request to exert more control over the army. In ''ComicBook/TransformersLastStandOfTheWreckers'' Brainstorm works at the Kimia Facility, an R & D lab full of mad scientists. And Brainstorm in particular is considered especially insane even by ''their'' standards. He makes a hobby of creating weapons so horrible, they're classified as unmentionable by the Ethics Committee. In ''ComicBook/TransformersMoreThanMeetsTheEye'' he builds all sorts of weapons [[spoiler: and a holding cell]] for the crew [[spoiler: and to hold Overlord]], including a gun designed to shrink people, a bomb designed to break the fourth wall, and a overpowered laser gun labelled My First Blaster (complete with flashing lights and sounds). Tellingly, when someone asks him about one of his inventions snuffing out a sun, he dismisses it as "filthy, stinking lies"... because they got a small detail wrong. The sun in question did get snuffed out.

* ComicBook/TransformersAllHailMegatron makes Brainstorm into one. He seemingly has no qualms about [[spoiler: putting suggestion ideas inside Kup's mind]] at Prowl's request to exert more control over the army. In ComicBook/TransformersLastStandOfTheWreckers Brainstorm works at the Kimia Facility, an R & D lab full of mad scientists. And Brainstorm in particular is considered especially insane even by ''their'' standards. He makes a hobby of creating weapons so horrible, they're classified as unmentionable by the Ethics Committee. In ComicBook/TransformersMoreThanMeetsTheEye he builds all sorts of weapons [[spoiler: and a holding cell]] for the crew [[spoiler: and to hold Overlord]], including a gun designed to shrink people, a bomb designed to break the fourth wall, and a overpowered laser gun labelled My First Blaster (complete with flashing lights and sounds). Tellingly, when someone asks him about one of his inventions snuffing out a sun, he dismisses it as "filthy, stinking lies"... because they got a small detail wrong. The sun in question did get snuffed out.

* ''TheAwesomeSlapstick'' had Dr. Denton, Destroyer of Worlds, a five-year-old genius who built a giant robotic teddy bear.

* Profesor Bacterio from ''MortadeloYFilemon''. Both T.I.A. agents have ''very good'' reasons to run away really fast when ordered to test one of his inventions.