History GameBreaker / TheBindingOfIsaac

So good luck. You'll need them in order to take down hard bosses such as Mother, Delirium or The Beast. Especially with The Lost. Or it's Tainted counterpart.

* The Ghost Pepper gives you a chance to shoot blue flames, similarly to the Blue Candle active item, the chance of which scales with luck. On its own, it is nice but not too overpowered. However, there also exists a trinket called Perfection, which gives an insane amount of luck but requires the player to play a NoDamageRun[[note]]For it to spawn, you need to play a few floors without taking damage, and taking damage with it equipped makes you lose it[[/note]]. Playing as The Lost or the Tainted Lost? Enjoy your tear flamethrower that deals insane damage and also blocks shots.

* Psy Fly is hands down one of the best orbitals in the game. It has the effect of intercepting shots that would hit Isaac and converting them into homing projectiles. It does the former at an ''astounding'' rate, such that even BulletHell bosses will have a hard time getting anywhere near you as long as you make an effort to stay away from heavy bullet spam. Even after Psy Fly was nerfed in November 2021 to only intercept a set number of projectiles before taking a break, it's still an absurdly strong orbital. Even the notes for the patch reassured players that the item is still broken.

* And finally, Death Certificate, unlocked by getting all hard mode marks with all 34 characters, teleports you to a special floor containing '''every item in the game''', separated into a couple dozen different rooms. Even items you haven't unlocked are available. You can pick a single item, then are teleported back to your original location. This is decent as is, but with certain items leads to a lot of exploits.

** The Red Key is also one of a few ways to find Ultra Secret Rooms, which have at least one Angel Room item costing a single key at most. With knowledge on how the Ultra Secret Room is placed and a bit of luck, every floor will grant one new angel item on top of what can already be found through devil deals or angel offerings, and any other special rooms spawned with the Red Key.

* Four words: '''[[https://m.youtube.com/watch?v=B15J81pnpgo Diplopia + Wild Card]]'''. First, find Diplopia and Wild Card in the same run. Second, drop Wild Card in an Angel Room. Third, use Diplopia and duplicate Wild Card. Fourth, use Wild Card to spawn even ''more'' Wild Cards. Repeat step 4 unlimited times to [[SerialEscalation spawn infinite Wild Cards]]. You could use this trick in a Devil Room to duplicate items and get them for free, use it in a shop to get items for free, or use it in an Angel Room and get multiple copies of a powerful item, like Sacred Heart. The possibilities are endless!

* Four words: '''[[https://m.youtube.com/watch?v=B15J81pnpgo Diplopia + Wild Card]]'''. First, find Diplopia. Second, drop Wild Card in an Angel Room. Third, use Diplopia and duplicate Wild Card. Fourth, use Wild Card to spawn even ''more'' Wild Cards. Repeat step 4 unlimited times to [[SerialEscalation spawn infinite Wild Cards]]. You could use this trick in a Devil Room to duplicate items and get them for free, use it in a shop to get items for free, or use it in an Angel Room and get multiple copies of a powerful item, like Sacred Heart. The possibilities are endless!

* Originally, Echo Chamber made it so that when using a pill or card, it activated ''every'' single effect of all of the pills and cards used since obtaining Echo Chamber. Even ignoring effects like Ancient Recall and Vurp which can stack infinite Cards/Pills, having an ever-growing pool of effects for every consumable was beyond busted and could easily carry an entire run. See [[https://www.youtube.com/watch?v=X3JkYcppD9o here]] for more details. Ultimately, Echo Chamber was [[Nerf nerfed]] to only copy the last three effects, which, to be clear, is still a ''really'' broken effect.

** 1.7.7 patch: While Echo Chamber was nerfed to only copy the last 3 card/pill effects, it can store copies of the same effect. This means that card/pill effects that spawn pickups can be stacked on top of each other. You know how the "Vurp!" pill creates another "Vurp!" when you have not previously taken any pills yet? Echo Chamber creates ''infinite multiple copies'' of "Vurp!" pills when taken repeatedly with the new Echo Chamber. [[https://www.youtube.com/watch?v=bfKIlzW3isY See here for more game-breaking details]].

* Originally, Echo Chamber made it so that when using a pill or card, it activated ''every'' single effect of all of the pills and cards used since obtaining Echo Chamber. Even ignoring effects like Ancient Recall and Vurp which can stack infinite Cards/Pills, having an ever-growing pool of effects for every consumable was beyond busted and could easily carry an entire run. See [[https://www.youtube.com/watch?v=X3JkYcppD9o here]] for more details. Ultimately, Echo Chamber was nerfed to only copy the last three effects, which, to be clear, is still a ''really'' broken effect.

* The D1, Isaac's Greedier Mode unlock, has the simple property of duplicating a random pickup in the room. In addition to all the normal pickups, this includes chests. However, if you remove all but one pickup from a room, then the D1 will duplicate it without fail. This essentially allows you to mimic the functions of the Blank Card and Placebo in a single item, albeit more tediously, or spawn as many chests as the floor will allow. Mix it with the Car Battery and a battery consumable to create infinite batteries and thus infinite charge for a floor, since it will create two batteries for every one consumed.

* Echo Chamber makes it so that when using a pill or card, it activates ''every'' single effect of all of the pills and cards used since obtaining Echo Chamber. Combining this with Ancient Recall (spawns 3 random cards) makes it so that you can draw and use as many cards as you want! (You can alternatively use Vurp! for infinite pills). If you can find runes like Jera or Perthro, you can throw those into the mix too and effectively have another Death Certificate-lite. See [[https://www.youtube.com/watch?v=X3JkYcppD9o here]] for more details.

* Mom's Ring. [[https://www.youtube.com/watch?v=wYBe5vWBcis&t=58s Swapping out and picking up again Mom's Ring as Tainted Isaac Tainted Isaac will always spawn an additional Rune/Soul Stone, allowing him to farm infinite runes if his inventory is full.]]

* Revelation. Imagine you took a pre-nerf Brimstone, then add in flight ''plus'' soul hearts, and what do you get? Something that makes angel rooms a '''lot''' more appealing.

* Psy Fly is hands down one of the best fly orbitals in the game. It has the effect of intercepting shots that would hit Isaac and converting them into homing projectiles. It does the former at an ''astounding'' rate, such that even BulletHell bosses will have a hard time getting anywhere near you as long as you make an effort to stay away from heavy bullet spam.

* Tainted Judas cannot have any regular hearts. Converter will try to give regular hearts but instead will just refund the black heart. When Converter consumes a black heart it deals 40 damage to all enemies and gives him another black heart, enabling an infinite loop that ''deals infinite mass damage to all enemies''.
** Tainted Bethany has a similar interaction, see [[[[https://www.youtube.com/watch?v=Z8TFx8e-aRQ here]].
* Dark Arts is an extraordinarily powerful item. To start with, it provides a one-second invulnerability period and speedup on an 8 second cooldown, which can be used to avoid difficult attack waves, skip puzzles, and open curse rooms with impunity. However, what it also does is mark enemies and projectiles, and once the invulnerability ends, you blitz through everything you touched, gaining increasing damage buffs for everything hit. With practice, you can exploit enemy attacks to become immensely powerful, to the point where bullet-spamming bosses like Hush and Mega Satan can be completely decimated if you take 20-30 shots in that brief period. In addition, the shadow strike scales off of damage, so if you manage to find Ipecac, your melee strikes can shred some bosses in a single hit if a few bullets are tagged first. It's very easy to practice with as well, as Tainted Judas starts with it in every run.

** Play as Tainted Samson, collect Berserker! and the Schoolbag, or Use a Soul of Samson, and collect Suplex. Now, grab ''anything enemy or bosses whatsoever'' while you're berserk. And watch them as they are instantly ''deleted'' after your berserk state expires. It can work on absolutely anything: from [[HarmlessEnemy a Black]] [[AwesomeButImpractical Fly]] to ''[[FinalBoss The Beast]]''. Just be careful to not use it against Dogma, as [[UnintentionallyUnwinnable you'll be trapped in the boss room if it's deleted]].

* In general across Rebirth and all its DLC, any item combination that allows Isaac to spawn and/or gain infinite items is certain to qualify, especially in Greed Mode. Blank Card/Clear Rune + Jera, D20 in Greed Mode, and Blank Card + 2 of Diamonds are just a few of the popular options.

* The R Key is a very rare but VERY powerful one-time use item that resets your run with your stats and items intact. It can allow the player to clear multiple routes in one run, such as getting a good break in the Chest, rerolling secret room items to the R Key, then blowing up the more difficult alternate path with a full prior run's worth of equipment to trivialize Mother.

** Come ''Repentance'', this combination is now rendered [[{{Nerf}} completely moot]], as combining Soy Milk and Libra will reduce your tear rate back to normal. But what Soy Milk ''does'' do, however, is make most charging shots, such as Brimstone, Monstro's Lung, and Tech X, fire '''constantly''' as long as you are holding down the attack button. If you're able to grab Soy Milk and a decent charging item early on in the run, you can handle most enemies and bosses quite well. And coupled with damage upgrades, the synergy is even more efficient.

* Cursed Eye allows you to shoot 4 charged tears, but the fact that it teleports you away if you're hit while charging it outweighs the benefits. Take it after taking Chocolate Milk (normal charged shots), and the game will combine the 4 tears into a single giant one, with quadruple damage ''and quadruple charge bonuses''.

** Come ''Repentance'', this combination is now rendered [[{{Nerf}} completely moot]], as combining Soy Milk and Libra will reduce your tear rate back to normal. But what it ''does'' do, however, is make most charging shots, such as Brimstone, Monstro's Lung, and Tech X, fire '''constantly''' as long as you are holding down the attack button. If you're able to grab Soy Milk and a decent charging item early on in the run, you can handle most enemies and bosses quite well. And coupled with damage upgrades, the synergy is even more efficient.

** Come ''Repentance'', this combination is now rendered [[Nerf completely moot]], as combining Soy Milk and Libra will reduce your tear rate back to normal. But what it ''does'' do, however, is make most charging shots, such as Brimstone, Monstro's Lung, and Tech X, fire '''constantly''' as long as you are holding down the attack button. If you're able to grab Soy Milk and a decent charging item early on in the run, you can handle most enemies and bosses quite well. And coupled with damage upgrades, the synergy is even more efficient.

** Play as Tainted Samson, collect Berserker! and the Schoolbag, or Use a Soul of Samson, and collect Suplex. Now, grab ''anything enemy or bosses whatsoever'' while you're berserk. And watch them as they are instantly ''deleted'' after your berserk state expires. It can work on absolutely anything: from [[HarmlessEnemy a Black]] [[AwesomeButImpractical Fly]] to ''[[FinalBoss The Beast]]''. Just be careful to not use it against Dogma, as [[UnwinnableByMistake you'll be trapped in the boss room if it's deleted]].

* Plan C seems to be something of a last resort item, as it deals [[NoKillLikeOverkill 9,999,999 damage]] to every enemy in the room...but then kills Isaac three seconds later, meaning you'll lose if the exit doesn't spawn right where you're standing. However, if you have a character that can come back from the dead, like Lazarus, or have an item that can revive you, like Dead Cat, it's effectively a button to instantly deal with any boss you don't like. It is most useful during the fight with The Beast and the 4 horsemen, which if used immediately wins you the run without dying 3 seconds later. It'll even take out Delirium, but this only works for Lazarus or if you have Inner Child in ''Repentance''.