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* The Card Against Humanity, when used in a large room with lots of ground tiles, will spawn an absolute mountain of poop, and breaking that many poops has a good chance of dropping money and hearts (normal and soul). If a Petrified Turd drops, then almost every poop destroyed will drop a pickup. Even if a Petrified Turd doesn't drop, you'll still come out with a fatter wallet and some soul hearts (especially if you have a Dark Bum to convert all the red hearts).
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* The Red Key. Using it can create an entirely new room. This room can be anything from a regular enemy-filled room, to an item room (even on floors where they wouldn't normally spawn), to a [[DealWithTheDevil Devil Deal]], and so on. By creating enough rooms to leave an invisible 13 x 13 grid, the player can even create an I AM ERROR room, and skip to the next floor.
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* The Red Key. Using it can create an entirely new room. This room can be anything from a regular enemy-filled room, to an item room (even on floors where they wouldn't normally spawn), to a [[DealWithTheDevil Devil Deal]], and so on. By creating enough rooms to leave an invisible 13 x 13 grid, the player can even create an I AM ERROR room, and skip to the next floor. When combined with certain charge-restoring items, it is possible to explore the entirety of the 13X13 grid, gathering numerous items along the way.
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* Finding the Bloody Penny allows one to convert money drops into red hearts. Blood donation machines do the reverse, but can pay out nickels or dimes. In tandem, this can produce infinite money and consumable health for a floor. If found in an arcade, the combo can be exploited for infinite keys, bombs, and Skatole. Even if the blood donation machine happens to pay out, it will drop the Blood Bag, which fills heart containers and gives an HP up, or the IV Bag, which acts as a portable, more reliable blood donation machine.
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* Finding the Bloody Penny allows one to convert money drops into red hearts. Blood donation machines do the reverse, but can pay out nickels or dimes. In tandem, this can produce infinite money and consumable health for a floor. If found in an arcade, the combo can be exploited for infinite keys, bombs, and Skatole. Even if the blood donation machine happens to pay out, it will drop the Blood Bag, which fills heart containers and gives an HP up, or the IV Bag, which acts as a portable, more reliable blood donation machine. If you happen to also carry Swallowed Penny and/or Piggy Bank, infinite money is much more easily achieved.
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** Damocles: Upon use, summons a sword that hangs directly above Isaac. As long as the sword hangs above Isaac, all item pedestals and items spawned from Machines and Beggars are doubled, spawning an additional, free item next to them. After Isaac gets hit once with the item activated, at any time without warning, the sword may fall, instantly killing Isaac regardless of his health. If used with Magic Skin or Genesis, it eventually spawns more items.
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** Damocles: Upon use, summons a sword that hangs directly above Isaac. As long as the sword hangs above Isaac, all item pedestals and items spawned from Machines and Beggars are doubled, spawning an additional, free item next to them. After Isaac gets hit once with the item activated, at any time without warning, the sword may fall, instantly killing Isaac regardless of his health. If used with Magic Skin or Genesis, it eventually spawns more items. For most characters, this item is very risky, unless getting an extra life. However, Lazarus starts with extra life every new floor, making it much safer to take. Meanwhile, for both normal Lost and Tainted Lost, getting hit equals death anyway so downsides of Damocles are naturally inconsequential.
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* Tainted Judas cannot have any regular hearts. Converter will try to give regular hearts but instead will just refund the black heart. When Converter consumes a black heart it deals 40 damage to all enemies and gives him another black heart, enabling an infinite loop that ''deals infinite mass damage to all enemies''. Tainted Bethany had a similar interaction, see [[https://www.youtube.com/watch?v=Z8TFx8e-aRQ here]]. This led to Converter sadly being ''heavily'' nerfed from an infinite use item to a 3-room charge.
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* Tainted Judas cannot have any regular hearts. Converter will try to give regular hearts but instead will just refund the black heart. When Converter consumes a black heart it deals 40 damage to all enemies and gives him another black heart, enabling an infinite loop that ''deals infinite mass damage to all enemies''. Tainted Bethany had a similar interaction, see [[https://www.youtube.com/watch?v=Z8TFx8e-aRQ here]]. This led to Converter sadly being ''heavily'' [[ObviousRulePatch nerfed from an infinite use item to a 3-room charge.charge]].
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** The Red Key is also one of a few ways to find Ultra Secret Rooms, which have at least one Angel Room item costing a single key at most. With knowledge on how the Ultra Secret Room is placed and a bit of luck, every floor will grant one new angel item on top of what can already be found through devil deals or angel offerings, and any other special rooms spawned with the Red Key. Ultra Secret Rooms were eventually changed, the item pool it draws from was changed from angel rooms to a unique item pool. The new Ultra Secret Room item pool consists of "Red" items. (Any item with a primarily red color scheme) While this increases the chance of getting low quality items like Sister Maggy and Angry Fly, there are still run winning items in the pool. Brimstone, Sacred Heart, D6, D20, Abyss, Magic Mushroom, and other great items are available .
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** The Red Key is also one of a few ways to find Ultra Secret Rooms, which have at least one Angel Room red-colored item costing a single key at most. With knowledge on how the Ultra Secret Room is placed and a bit of luck, every floor will grant one new angel item on top of what can already be found through devil deals or angel offerings, and any other special rooms spawned with the Red Key. Ultra Secret Rooms were eventually changed, the item pool it draws from was changed from angel rooms to a unique item pool. The new Ultra Secret Room item pool consists of "Red" items. (Any item with a primarily red color scheme) While this increases the chance of getting low quality items like Sister Maggy and Angry Fly, there are still run winning items in the pool. Brimstone, Sacred Heart, D6, D20, Abyss, Magic Mushroom, and other great items are available .
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* Tainted Cain is one of the most frustrating characters in the game but also one of, if not THE strongest character in the game. If he touches a pedestal item, it bursts into a bunch of consumables based on the item pool it's from. These can then be picked up by the Bag of Crafting, which can store 8 consumables, such as hearts, coins, keys and bombs. When the bag has 8 items you can hold down the activate button for 2 seconds to craft yourself a brand new item, including some of the game-breakers here.
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* Tainted Cain is one of the most [[DifficultButAwesome frustrating characters in the game but also one of, if not THE strongest character in the game. game.]] If he touches a pedestal item, it bursts into a bunch of consumables based on the item pool it's from. These can then be picked up by the Bag of Crafting, which can store 8 consumables, such as hearts, coins, keys and bombs. When the bag has 8 items you can hold down the activate button for 2 seconds to craft yourself a brand new item, including some of the game-breakers here.
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** For those who are disappointed by the [[GlassCannon relative fragility]] of the Book of Virtues wisps, Box of Spiders works wonders. It spawns a whopping ''six wisps'' when activated, with each of these wisps spawning friendly blue spiders when destroyed. Even better, this synergy has a measly two room recharge, which can easily be reduced to one room with any item that reduces active item charge. Combined with Bethany's innate soul charge mechanic ensuring a full charge is on standby every time she gains a soul heart, and you can spam wisp summons as easily as they're destroyed, allowing you to constantly [[ZergRush swarm the enemy with both attack spiders and a healthy quantity of wisp projectiles.]]
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Seriously this trinket is downright busted.
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* The 'M trinket causes the held active item to be rerolled to another active item whenever it's used, and rerolls it over and over so long as the trinket is held. Unless it is obtained late in the run, this means that the player can effectively have almost any active item in the game that they want, as most actives charge within only a few rooms. The biggest downside is that one time-use items still disappear rather than being rerolled, but it is easy enough to find another active item, and most of the one time-use items are supremely powerful on their own. Even after getting a good item, the player can simply drop the trinket and keep a hold on to it. It is possible to even turn something like the Bean in to items such as R Key or Death Certificate with this if fortune shines bright enough. 'M's effects also ignore if an item is taken out of a pool or not, so multiple copies of the same active can be rerolled in one run.
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* The Scapular gives you a soul heart one per room once you are on the last half heart (normal) or, on [[spoiler:???]], when you lose your last heart. Done right, you can use this to get lots of money from a heart donation machine by going to low health, exiting the room and going back after getting the extra soul heart, and use the machine twice, once in later levels, giving you another one. Exit, repeat. It also helps that it's basically regenerating health, allowing you more error. That ratio for error is small, but it's better than not being able to make error, but that part isn't really breaking.
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* The Scapular gives you a soul heart one once per room once you are on the your last half heart (normal) or, on [[spoiler:???]], when you lose your last heart. Done right, you can use this to get lots of money from a heart donation machine by going to low health, exiting the room and going back after getting the extra soul heart, and use the machine twice, once in later levels, giving you another one. Exit, repeat. It also helps that it's basically regenerating health, allowing you more error. That ratio for error is small, but it's better than not being able to make error, but that part isn't really breaking.
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* The Guppy transformation. It requires touching any three of Guppy's Paw, Guppy's Head, Guppy's Tail, Guppy's Collar, Guppy's Hairball, and the Dead Cat items, meaning that you'll likely have to spend a lot of heart containers to transform unless you get very lucky with Red Chests. The transformation itself grants flight and causes every tear that hits to spawn a kamikaze fly. These flies deal twice as much damage as the player's tears, and one is spawned for ''any'' tear that hits. Add in any tear-firing familiars (or just a high fire rate), and just watch as anything before you gets cut down by an army of flies.
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* The Guppy transformation. It requires touching any three of Guppy's Paw, Guppy's Head, Guppy's Tail, Guppy's Collar, Guppy's Hairball, and the Dead Cat items, meaning that you'll likely have to spend a lot of heart containers to transform unless you get very lucky with Red Chests. The transformation itself grants flight and causes every tear that hits an enemy to spawn a kamikaze fly. These flies deal twice as much damage as the player's tears, and one is spawned for ''any'' tear that hits. Add in any tear-firing familiars (or just a high fire rate), and just watch as anything before you gets cut down by an army of flies.
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* In a mechanic example, Mom's Knife, Epic Fetus, and Brimstone, items which override most other forms of tears, can break the challenges by potentially replacing your worthless loadout with a far superior normal weapon. The remake gets around this with the Blindfolded mechanic present in some challenges, which completely disables tears.
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* In a mechanic example, Mom's Knife, Epic Fetus, and Brimstone, items which override most other forms of tears, can break the challenges by potentially replacing your worthless loadout with a far superior normal weapon. The remake gets around this with the Blindfolded mechanic present in some challenges, which completely disables tears.tears (though you can still use Mom's Knife as a melee weapon if you're daring).
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* And then there's the [[VideoGame/SuperMarioBros3 Gnawed Leaf]]. It makes Isaac immune to all damage when he stands still for two seconds, but that immunity goes away when he moves or shoots a tear. If you couple this with an item that does damage by itself without any player input (of which there are quite a few), it makes it impossible to lose under most circumstances. Especially if you have a level 3 or 4 Meat Boy or Bandage Girl or the Pinked Shears. Then, as long as no enemy is behind an obstacle, you just sit back and let Meat Boy, Bandage Girl, or Isaac's body kill everything. Even with just a damaging orbital it can trivialize a lot of rooms. And if you get Daddy Longlegs together with this, every room in the game (without a Host in it at least) turns into "Isaac WinsByDoingAbsolutelyNothing". [[note]]''Repentance'' [[ObviousRulePatch nerfed this]] for the [[spoiler:Hush]] fight by giving him RegeneratingHealth that kicks in if he isn't attacked at all for several seconds while at low health, but everything else is still fair game.[[/note]]
* The Broken Remote trinket turns the effect of your spacebar item into a teleport. Combine with any zero-charge spacebar item for [[TeleportSpam unlimited teleports]]. With patience, this combination guarantees access to every room visible on the map, including each floor's shop, Item Room, rarer rooms like the Dice Room/Library/Bedroom... and removes the need to spend keys and bombs to get there. That you get to escape/skip problematic rooms is a nice bonus.
* The Broken Remote trinket turns the effect of your spacebar item into a teleport. Combine with any zero-charge spacebar item for [[TeleportSpam unlimited teleports]]. With patience, this combination guarantees access to every room visible on the map, including each floor's shop, Item Room, rarer rooms like the Dice Room/Library/Bedroom... and removes the need to spend keys and bombs to get there. That you get to escape/skip problematic rooms is a nice bonus.
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* And then there's the [[VideoGame/SuperMarioBros3 Gnawed Leaf]]. It makes Isaac immune to all damage when he stands still for two seconds, but that immunity goes away when he moves or shoots a tear. If you couple this with an item that does damage by itself without any player input (of which there are quite a few), it makes it impossible to lose under most circumstances. Especially if you have a level 3 or 4 Meat Boy or Bandage Girl or the Pinked Shears. Then, as long as no enemy is behind an obstacle, you just sit back and let Meat Boy, Bandage Girl, or Isaac's body kill everything. Even with just a damaging orbital orbital, it can trivialize a lot of rooms. And if you get Daddy Longlegs together with this, every room in the game (without a Host in it at least) turns into "Isaac WinsByDoingAbsolutelyNothing". [[note]]''Repentance'' [[ObviousRulePatch nerfed this]] for the [[spoiler:Hush]] fight by giving him RegeneratingHealth that kicks in if he isn't attacked at all for several seconds while at low health, but everything else is still fair game.[[/note]]
* The Broken Remote trinket turns the effect of your spacebar item into a teleport. Combine with any zero-charge spacebar item for [[TeleportSpam unlimited teleports]]. With patience, this combination guarantees access to every room visible on the map, including each floor's shop, Item Room, rarer rooms like the Dice Room/Library/Bedroom... and removes the need to spend keys and bombs to get there. That you get to escape/skip problematic rooms is a nice bonus. And since the Broken Remote is a trinket, you can just drop it if you need your active item for something (such as using How To Jump to grab a pickup behind a rock or a pit), then pick it back up when you're done.
* The Broken Remote trinket turns the effect of your spacebar item into a teleport. Combine with any zero-charge spacebar item for [[TeleportSpam unlimited teleports]]. With patience, this combination guarantees access to every room visible on the map, including each floor's shop, Item Room, rarer rooms like the Dice Room/Library/Bedroom... and removes the need to spend keys and bombs to get there. That you get to escape/skip problematic rooms is a nice bonus. And since the Broken Remote is a trinket, you can just drop it if you need your active item for something (such as using How To Jump to grab a pickup behind a rock or a pit), then pick it back up when you're done.
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** Add Parasite to Ludovico and Strange Attractor and you'll be creating ''multiple'' gravity wells that will pull the enemy around ''so fast'' that they will appear to be torn apart not from damage but from cycling through quantum states until you observe them dead and collapse the waveform as a bloodstain on the floor.
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** Add Parasite to Ludovico and Strange Attractor and you'll be creating ''multiple'' gravity wells that will pull the enemy around ''so fast'' that they will appear to be torn apart not from damage damage, but from cycling through quantum states until you observe them dead and collapse the waveform as a bloodstain on the floor.
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** Even better: Combine it with [[WhyAmITicking Kamikaze!]] Once you do, congratulations -- you now have a means of gaining free health ''on demand'' that's also an offensive maneuver. Victory by this point is pretty much a given.
** Many non-bullet attacks by end-game bosses count as explosions. In other words, both Mom's/Satan's stomping attacks and Mega Satan's hand smashes will ''heal'' you if you have a Pyromaniac. And yes, this includes the constant stomping you get from picking up the Broken Shovel, which makes unlocking the Forgotten ''much'' easier.
** Many non-bullet attacks by end-game bosses count as explosions. In other words, both Mom's/Satan's stomping attacks and Mega Satan's hand smashes will ''heal'' you if you have a Pyromaniac. And yes, this includes the constant stomping you get from picking up the Broken Shovel, which makes unlocking the Forgotten ''much'' easier.
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** Even better: Combine it with [[WhyAmITicking Kamikaze!]] Once you do, congratulations -- you now have a means of gaining free health ''on demand'' that's also an offensive maneuver. Victory by this point is pretty much a given.
given.[[note]]There is a challenge that gives you both Kamikaze and Pyromaniac. Needless to say, it has you play as ??? just so that there's a non-zero chance for you to lose.[[/note]]
** Many non-bullet attacks by end-game bosses count as explosions. In other words, both Mom's/Satan's stomping attacks and Mega Satan's hand smashes will ''heal'' you if you have a Pyromaniac. And yes, this includes the constant stomping you get from picking up the Broken Shovel, which makes unlocking the Forgotten ''much'' easier. Unfortunately, this was changed in ''Repentance''.
** Many non-bullet attacks by end-game bosses count as explosions. In other words, both Mom's/Satan's stomping attacks and Mega Satan's hand smashes will ''heal'' you if you have a Pyromaniac. And yes, this includes the constant stomping you get from picking up the Broken Shovel, which makes unlocking the Forgotten ''much'' easier. Unfortunately, this was changed in ''Repentance''.
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* Mr. ME! is a great asset in normal play, but utterly BREAKS Greed mode. You can use it to nab items in Shops or Devil Rooms without paying, and since Greed Mode lets you recharge items pretty quickly and has a shop that always restocks, you can gain a bunch of items for free.
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* Mr. ME! is a great asset ''devastatingly'' effective asset, as he pretty much allows you to sidestep almost ''every'' barrier between you and the good stuff without actually meeting the criteria to get it. He can open any locked door and steal any item for free. That is ''any'' locked door, including Boss Challenge Rooms which you're expected to go into with only 1 heart, and ''the door to Mega Satan'' so you don't have to screw around with Angel Rooms. Also ''any'' item, including ''Devil Room'' deals which doesn't lock you out of Angel Rooms either. This is all in normal play, but addition to also being able to open bombable walls to secret rooms, grabbing any out-of-reach item or chest and bringing it to you, and even attacking enemies if you'd like. His only real drawback is he has a chance of not stealing an item. Furthermore, he utterly BREAKS Greed mode. You can use it to nab items in Shops or Devil Rooms without paying, and since Greed Mode lets you recharge items pretty quickly and has a shop that always restocks, you can gain a bunch of items for free.free really quickly and just tank Ultra Greed. The thing that ''really'' makes this guy so broken though, is his cost and rarity: he's a ''common'' passive item in the shop and Key Master item pools and costs only a paltry 15 coins, meaning you can almost rely on getting this guy unlike Brimstone or Mama MEGA! which only pop up once in a blue moon. And, if none of that was enough, he ''also'' only has a 4 room charge time.
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* Tainted Bethany: Instead of the Book of Virtues, she wields the Lemegeton, whose wisps instead summon a wisp depicting a random passive item. As long as that wisp is kept alive, you get to ''keep'' that item. And since the Book is charged by the much more plentiful red hearts, you'll soon amass a ton of items to steamroll the rest of the game. Combine it was Car Battery (or even getting one ''from'' Lemegeton)? She can rip through practically everything.
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* Tainted Bethany: Instead of the Book of Virtues, she wields the Lemegeton, whose wisps instead summon a wisp depicting a random passive item. As long as that wisp is kept alive, you get to ''keep'' that item. And since the Book is charged by the much more plentiful red hearts, you'll soon amass a ton of items to steamroll the rest of the game. Combine it was with Car Battery (or even getting get one ''from'' Lemegeton)? She Lemegeton) and she can rip through practically everything.
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** The real kicker comes in when you do this in The Void, which ''resets the floor'', allowing the player to get more items and repeat the process, ad infinitum. If used in The Chest or the Dark Room, it teleports you to The Void, allowing you to fight Delirium.
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** The real kicker comes in when you do this in The Void, which ''resets the floor'', allowing the player to get more items and repeat the process, ad infinitum. ''ad infinitum''. If used in The Chest or the Dark Room, it teleports you to The Void, allowing you to fight Delirium.Delirium without having to rely on the chance of a portal.
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* The freeze effect[[note]]not to be confused with the petrifying effect, which is sometimes called "freezing"[[/note]] is insanely good for crowd control. Enemies killed by freeze damage become ice statues (this prevents on-death effects like releasing tear bursts or exploding), and they can be kicked by the player and sent sliding, leaving a trail of damaging blue creep behind them and, upon hitting an enemy[[note]]in which case, the frozen enemy deals a good 35 points of impact damage[[/note]], wall or obstacle, shattering in a starburst of icicles that deal high damage and can slow or petrify living enemies. The kicker is, any enemies killed by those icicles ''also freeze'', [[DisasterDominoes in a self-repeating cycle that spells doom for entire groups of foes]]. And of the four items[[labelnote:list]]Cube Baby, Freezer Baby, Uranus and the Ice Cube trinket[[/labelnote]] that deal freeze damage (not counting random tear effects like Fruit Cake or Playdough Cookie), Uranus stands above all: it gives the ice effect to ''all'' of your tears, and it synergizes well with many strong items, ''including Brimstone and Technology''. Ice and freezing only falter against bosses, who are naturally immune to freezing; that said, they have no immunity to the damage or slow/petrify effects of icicles from shattered enemies in case [[FlunkyBoss they spawn with or summon backup]].
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* Tainted Bethany: Instead of the Book of Virtues, she wields the Lemegeton, whose wisps instead summon a wisp depicting a random passive item. As long as that wisp is kept alive, you get to ''keep'' that item. And since the Book is charged by the much more plentiful red hearts, you'll soon amass a ton of items to steamroll the rest of the game.
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* Tainted Bethany: Instead of the Book of Virtues, she wields the Lemegeton, whose wisps instead summon a wisp depicting a random passive item. As long as that wisp is kept alive, you get to ''keep'' that item. And since the Book is charged by the much more plentiful red hearts, you'll soon amass a ton of items to steamroll the rest of the game. Combine it was Car Battery (or even getting one ''from'' Lemegeton)? She can rip through practically everything.
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* A Pound of Flesh spends a lot of its time being a relatively balanced item, simply swapping the mechanics of Shops and Devil Rooms. Even when playing as [[OneHitPointWonder The Lost]], you can only freely buy one Shop pedestal item via the Pound of Flesh. However, if The Lost has both that and Restock[[note]]replaces a bought shop item with another of the same kind[[/note]], they can not only buy infinite pickups[[note]]keys, bombs, cards, etc.[[/note]] for free, but also infinite collectibles from at least one pedestal. Combine that with at least one reroll machine, and The Lost essentially has a free win with just two items.
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* Tainted Judas cannot have any regular hearts. Converter will try to give regular hearts but instead will just refund the black heart. When Converter consumes a black heart it deals 40 damage to all enemies and gives him another black heart, enabling an infinite loop that ''deals infinite mass damage to all enemies''. Tainted Bethany had a similar interaction, see [[[[https://www.youtube.com/watch?v=Z8TFx8e-aRQ here]]. This led to Converter sadly being ''heavily'' nerfed from an infinite use item to a 3-room charge.
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* Tainted Judas cannot have any regular hearts. Converter will try to give regular hearts but instead will just refund the black heart. When Converter consumes a black heart it deals 40 damage to all enemies and gives him another black heart, enabling an infinite loop that ''deals infinite mass damage to all enemies''. Tainted Bethany had a similar interaction, see [[[[https://www.[[https://www.youtube.com/watch?v=Z8TFx8e-aRQ here]]. This led to Converter sadly being ''heavily'' nerfed from an infinite use item to a 3-room charge.
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Up To Eleven is a defunct trope
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** Taken UpToEleven if you buy Guppy's Paw with those new heart containers. Guppy's Paw destroys one heart container in exchange for three soul/spirit hearts. Tough choice, right? Not if you already have 5 or 6 heart containers. Use up four or five of them, and that's an instant 12 or 15 spirit hearts!
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** Taken UpToEleven up to eleven if you buy Guppy's Paw with those new heart containers. Guppy's Paw destroys one heart container in exchange for three soul/spirit hearts. Tough choice, right? Not if you already have 5 or 6 heart containers. Use up four or five of them, and that's an instant 12 or 15 spirit hearts!
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** Isaac's Heart. This spawns a heart familiar that takes damage for you while making your character ''NighInvulnerable''. Curse Rooms? Free access to them. Blood Donation Machines? Infinite money with no cost whatsoever [[labelnote:Explanation]][[LetsPlay/TearOfGrace Ladies and Gentlemen, Isaac's Heart. Making an Item that is typically a absolute bag of fucking soggy bollocks, probably the next thing since freshly sucked nob!]][[/labelnote]]. Devil Beggars? Free items, as well as a few neat pickups. Items that require touching enemies, such as Midas' Touch? Abuse it as much as you like! Blood Rights? ''[[UpToEleven A guaranteed clear for every room and boss]]'', as you can freely abuse it with no health cost. The only downside is that every enemy and boss targets the heart instead of you, but as long as you can protect it, you've gotten yourself one hell of an item.
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** Isaac's Heart. This spawns a heart familiar that takes damage for you while making your character ''NighInvulnerable''. Curse Rooms? Free access to them. Blood Donation Machines? Infinite money with no cost whatsoever [[labelnote:Explanation]][[LetsPlay/TearOfGrace Ladies and Gentlemen, Isaac's Heart. Making an Item that is typically a absolute bag of fucking soggy bollocks, probably the next thing since freshly sucked nob!]][[/labelnote]]. Devil Beggars? Free items, as well as a few neat pickups. Items that require touching enemies, such as Midas' Touch? Abuse it as much as you like! Blood Rights? ''[[UpToEleven A ''A guaranteed clear for every room and boss]]'', boss'', as you can freely abuse it with no health cost. The only downside is that every enemy and boss targets the heart instead of you, but as long as you can protect it, you've gotten yourself one hell of an item.
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* Soy Milk is a kinda bad item at first. It gives you a huge tear rate, but piddling damage. But if you get Libra? Then the game is over, because all of your stats get balanced with your high tear rate, giving you huge damage, as well as everything else, including a still high tear rate. [[UpToEleven Also, feel free to get Guppy if you want.]] [[https://www.youtube.com/watch?v=w4Pzb8snKnc Omgarrett shows off this broken combo here.]]
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* Soy Milk is a kinda bad item at first. It gives you a huge tear rate, but piddling damage. But if you get Libra? Then the game is over, because all of your stats get balanced with your high tear rate, giving you huge damage, as well as everything else, including a still high tear rate. [[UpToEleven Also, feel free to get Guppy if you want.]] want. [[https://www.youtube.com/watch?v=w4Pzb8snKnc Omgarrett shows off this broken combo here.]]
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* Speaking of Lilith, the Incubus familiar itself qualifies. It is a familiar that almost completely copies your tear stats and effects, having one on a character without a blindfold will basically give you 20/20, except it can also [[UpToEleven copy]] ''[[UpToEleven that]]''.
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* Speaking of Lilith, the Incubus familiar itself qualifies. It is a familiar that almost completely copies your tear stats and effects, having one on a character without a blindfold will basically give you 20/20, except it can also [[UpToEleven copy]] ''[[UpToEleven that]]''.copy ''that''.
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* For your consideration: Sad Bombs cause 8 tears to fly out in the cardinal directions from every bomb you use. Proptosis causes your tears to do huge damage on close-range targets, but die off farther away. Bomber Boy causes your explosions to detonate in a huge cross shape, similar to the bombs from {{VideoGame/Bomberman}}. Bobby-Bomb causes your bombs to home in on enemies. Mix these together (adding a damage boost for optimum effect), and boss fights are no longer an issue. Forget wiping out rooms full of enemies; if used properly, one of these bombs can one-shot most ''bosses'', up to and including '''[[Main/UpToEleven Mom's Heart]]'''.
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* For your consideration: Sad Bombs cause 8 tears to fly out in the cardinal directions from every bomb you use. Proptosis causes your tears to do huge damage on close-range targets, but die off farther away. Bomber Boy causes your explosions to detonate in a huge cross shape, similar to the bombs from {{VideoGame/Bomberman}}. Bobby-Bomb causes your bombs to home in on enemies. Mix these together (adding a damage boost for optimum effect), and boss fights are no longer an issue. Forget wiping out rooms full of enemies; if used properly, one of these bombs can one-shot most ''bosses'', up to and including '''[[Main/UpToEleven Mom's Heart]]'''.'''Mom's Heart'''.
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* The Nail. When used, it gives a spirit heart, increases damage, and lets player walk over rocks among with the other benefits. This was even more broken in earlier versions, where it gave ''two'' spirit hearts.
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* The Nail. When used, it gives a spirit heart, increases damage, and lets the player walk over rocks among along with the other benefits. This was even more broken in earlier versions, where it gave ''two'' spirit hearts.
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** It's even more overpowered with Polyphemus, which does ridiculous damage but sets tears to minimum. It's balanced, but with Technology 2 will down all bosses in seconds and one shot enemies.
* Speaking of Polyphemus, it synergises insanely with Brimstone. Polybrim, as it is sometimes called, deals insane amounts of damage (that can be more than doubled via the Brimsnap glitch[[labelnote:explanation]]Named after its discoverer, ''The Binding of Isaac'' [[Website/YouTube YouTuber]] streamer [[https://www.youtube.com/channel/UCyHqXCNrWYWq2DksYJzwciQ Bisnap]], this glitch allowed you to fire off multiple invisible fully-charged Brimstone lasers by tapping a direction key multiple times after releasing the initial charge, without needing to charge again. This glitch was fixed in ''Rebirth''.[[/labelnote]]) and its only draw, the long charging time, can be bypassed, at least for one shot, by charging it up before entering a room with enemies. With this combo, you can one-shot all enemies ''and most bosses'' within seconds.
** Polyphemus also synergises well with any weapon where the tears stat matters little (Dr Fetus, Ipecac, Tech 2, Mom's Knife, etc)
* Speaking of Polyphemus, it synergises insanely with Brimstone. Polybrim, as it is sometimes called, deals insane amounts of damage (that can be more than doubled via the Brimsnap glitch[[labelnote:explanation]]Named after its discoverer, ''The Binding of Isaac'' [[Website/YouTube YouTuber]] streamer [[https://www.youtube.com/channel/UCyHqXCNrWYWq2DksYJzwciQ Bisnap]], this glitch allowed you to fire off multiple invisible fully-charged Brimstone lasers by tapping a direction key multiple times after releasing the initial charge, without needing to charge again. This glitch was fixed in ''Rebirth''.[[/labelnote]]) and its only draw, the long charging time, can be bypassed, at least for one shot, by charging it up before entering a room with enemies. With this combo, you can one-shot all enemies ''and most bosses'' within seconds.
** Polyphemus also synergises well with any weapon where the tears stat matters little (Dr Fetus, Ipecac, Tech 2, Mom's Knife, etc)
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** It's even more overpowered with Polyphemus, which does ridiculous damage but sets tears to minimum. It's balanced, but with Technology 2 2, it will down all bosses in seconds and one shot one-shot enemies.
* Speaking of Polyphemus, it synergises insanely with Brimstone. Polybrim, as it is sometimes called, deals insane amounts of damage (that can be more than doubled via the Brimsnap glitch[[labelnote:explanation]]Named after its discoverer, ''The Binding of Isaac'' [[Website/YouTube YouTuber]] streamer [[https://www.youtube.com/channel/UCyHqXCNrWYWq2DksYJzwciQ Bisnap]], this glitch allowed you to fire off multiple invisible fully-charged Brimstone lasers by tapping a direction key multiple times after releasing the initial charge, without needing to charge again. This glitch was fixed in ''Rebirth''.[[/labelnote]]) and its onlydraw, drawback, the long charging time, can be bypassed, at least for one shot, by charging it up before entering a room with enemies. With this combo, you can one-shot all enemies ''and most bosses'' within seconds.
** Polyphemus also synergises well with any weapon where the tears stat matters little(Dr (Dr. Fetus, Ipecac, Tech 2, Mom's Knife, etc)etc.).
* Speaking of Polyphemus, it synergises insanely with Brimstone. Polybrim, as it is sometimes called, deals insane amounts of damage (that can be more than doubled via the Brimsnap glitch[[labelnote:explanation]]Named after its discoverer, ''The Binding of Isaac'' [[Website/YouTube YouTuber]] streamer [[https://www.youtube.com/channel/UCyHqXCNrWYWq2DksYJzwciQ Bisnap]], this glitch allowed you to fire off multiple invisible fully-charged Brimstone lasers by tapping a direction key multiple times after releasing the initial charge, without needing to charge again. This glitch was fixed in ''Rebirth''.[[/labelnote]]) and its only
** Polyphemus also synergises well with any weapon where the tears stat matters little
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* Scratch that, [=WotL=] brings in the [=D20=] from ''TabletopGame/DungeonsAndDragons'' fame. It rerolls every single pick up in the room, so you can reroll marginally useful items like pennies and half hearts and get pills, soul hearts, faith hearts, tarot and poker cards, nickels, dimes, the whole spectrum of trinkets and chests with several pickups inside, possibly even a powerup. Chances of getting great stuff are low per pickup, but then you go to an Arcade and pile up a huge stack of half hearts, keys, etc from the machines to polymorph at once. Good thing it has a 6 room recharge...
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* Scratch that, [=WotL=] brings in the [=D20=] from ''TabletopGame/DungeonsAndDragons'' fame. It rerolls every single pick up pickup in the room, so you can reroll marginally useful items like pennies and half hearts and get pills, soul hearts, faith hearts, tarot and poker cards, nickels, dimes, the whole spectrum of trinkets and chests with several pickups inside, possibly even a powerup. Chances of getting great stuff are low per pickup, but then you go to an Arcade and pile up a huge stack of half hearts, keys, etc etc. from the machines to polymorph at once. Good thing it has a 6 room recharge...
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* The Ankh, which revives you as [[spoiler:???/Blue Baby]] if you die. In terms of Steam Achievements and game content, you ARE [[spoiler:him]]. This nullifies half of the challenge of beating the game with [[spoiler:him]] if you get the Ankh on a lucky run with another character and die on purpose. It also makes it entirely possible to unlock the Forget Me Now and the Rainbow Baby before obtaining the D6.
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* The Ankh, which revives you as [[spoiler:???/Blue Baby]] if you die. In terms of Steam Achievements and game content, you ARE ''are'' [[spoiler:him]]. This nullifies half of the challenge of beating the game with [[spoiler:him]] if you get the Ankh on a lucky run with another character and die on purpose. It also makes it entirely possible to unlock the Forget Me Now and the Rainbow Baby before obtaining the D6.
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* Finding the Bloody Penny allows one to convert money drops into red hearts. Blood donation machines do the reverse, but can pay out nickels or dimes. In tandem, this can produce infinite money and consumable health for a floor. If found in an arcade, the combo can be exploited for infinite keys, bombs and Skatole. Even if the blood donation machine happens to pay out, it will drop the Blood Bag, which fills heart containers and gives an HP up, or the IV Bag, which acts as a portable, more reliable blood donation machine.
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* Finding the Bloody Penny allows one to convert money drops into red hearts. Blood donation machines do the reverse, but can pay out nickels or dimes. In tandem, this can produce infinite money and consumable health for a floor. If found in an arcade, the combo can be exploited for infinite keys, bombs bombs, and Skatole. Even if the blood donation machine happens to pay out, it will drop the Blood Bag, which fills heart containers and gives an HP up, or the IV Bag, which acts as a portable, more reliable blood donation machine.
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* The Guppy transformation. It requires touching any three of Guppy's Paw, Guppy's Head, Guppy's Tail, Guppy's Collar, Guppy's Hairball, and the Dead Cat items, meaning that you'll likely have to spend a lot of heart containers to transform unless you get very lucky with Red Chests. The transformation itself grants flight and causes every tear that hits to spawn a kamikaze fly. These flies deal twice as much damage as the player's tears, and one is spawned for ANY tear that hits. Add in any tear-firing familiars (or just a high fire rate), and just watch as anything before you gets cut down by an army of flies.
* And then there's the literal GameBreaker: Scapular+Habit+either reroll item. By bringing yourself to half of a red heart, running into a level hazard (such as a torch, some spikes, or a Curse Room door), and then leaving and re-entering the room (to reset Scapular), you can generate infinite rerolls. The usual outcome tends to be gigantic tears firing in four directions that home in on enemies, pierce them, and follow Isaac around to just destroy everything, with Guppy's flies on top of that. If the player lucks out and gets a God Room for the floor, the potential for firing bullets ''backwards'' is possible. Where it becomes literal is that you can generate so many items that if you pick up too many spacebar items the game just gives up and crashes.
* In a mechanic example, Mom's Knife, Epic Fetus, and Brimstone, items which override most other forms of tears, can break the challenge maps by potentially replacing your worthless loadout with a far superior normal weapon. The remake gets around this with the Blindfolded mechanic present in some challenges, which completely disables tears.
* Three Pretty Flies. These can be acquired in a myriad of ways, including passive items, pills, and slot machines, and thus it's pretty reliably easy to get three of them in a run regardless of luck. With three, you become ''immune to all standard enemy projectiles'' (as well as flies). Suddenly a whole lot of things just can't hurt you and the only threats become contact damage, explosions, and beam-type attacks. Ever wanted to beat [[spoiler:Mom's Heart]], [[spoiler:It Lives]], and even ''[[spoiler:Issac]]'' without taking a single hit, well here you go.
* And then there's the literal GameBreaker: Scapular+Habit+either reroll item. By bringing yourself to half of a red heart, running into a level hazard (such as a torch, some spikes, or a Curse Room door), and then leaving and re-entering the room (to reset Scapular), you can generate infinite rerolls. The usual outcome tends to be gigantic tears firing in four directions that home in on enemies, pierce them, and follow Isaac around to just destroy everything, with Guppy's flies on top of that. If the player lucks out and gets a God Room for the floor, the potential for firing bullets ''backwards'' is possible. Where it becomes literal is that you can generate so many items that if you pick up too many spacebar items the game just gives up and crashes.
* In a mechanic example, Mom's Knife, Epic Fetus, and Brimstone, items which override most other forms of tears, can break the challenge maps by potentially replacing your worthless loadout with a far superior normal weapon. The remake gets around this with the Blindfolded mechanic present in some challenges, which completely disables tears.
* Three Pretty Flies. These can be acquired in a myriad of ways, including passive items, pills, and slot machines, and thus it's pretty reliably easy to get three of them in a run regardless of luck. With three, you become ''immune to all standard enemy projectiles'' (as well as flies). Suddenly a whole lot of things just can't hurt you and the only threats become contact damage, explosions, and beam-type attacks. Ever wanted to beat [[spoiler:Mom's Heart]], [[spoiler:It Lives]], and even ''[[spoiler:Issac]]'' without taking a single hit, well here you go.
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* The Guppy transformation. It requires touching any three of Guppy's Paw, Guppy's Head, Guppy's Tail, Guppy's Collar, Guppy's Hairball, and the Dead Cat items, meaning that you'll likely have to spend a lot of heart containers to transform unless you get very lucky with Red Chests. The transformation itself grants flight and causes every tear that hits to spawn a kamikaze fly. These flies deal twice as much damage as the player's tears, and one is spawned for ANY ''any'' tear that hits. Add in any tear-firing familiars (or just a high fire rate), and just watch as anything before you gets cut down by an army of flies.
* And then there's the literal GameBreaker: Scapular+Habit+either reroll item. By bringing yourself to half of a red heart, running into a level hazard (such as a torch, some spikes, or a Curse Room door), and then leaving and re-entering the room (to reset Scapular), you can generate infinite rerolls. The usual outcome tends to be gigantic tears firing in four directions that home in on enemies, pierce them, and follow Isaac around to just destroy everything, with Guppy's flies on top of that. If the player lucks out and gets a God Room for the floor, the potential for firing bullets ''backwards'' is possible. Where it becomes literal is that you can generate so many items that if you pick up too many spacebaritems items, the game just gives up and crashes.
* In a mechanic example, Mom's Knife, Epic Fetus, and Brimstone, items which override most other forms of tears, can break thechallenge maps challenges by potentially replacing your worthless loadout with a far superior normal weapon. The remake gets around this with the Blindfolded mechanic present in some challenges, which completely disables tears.
* Three Pretty Flies. These can be acquired in a myriad of ways, including passive items, pills, and slot machines, and thus it's pretty reliably easy to get three of them in a run regardless of luck. With three, you become practically ''immune to all standard enemy projectiles'' (as well as flies). Suddenly a whole lot of things just can't hurt you and the only threats become contact damage, explosions, and beam-type attacks. Ever wanted to beat [[spoiler:Mom's Heart]], [[spoiler:It Lives]], and even ''[[spoiler:Issac]]'' without taking a single hit,well well, here you go.
* And then there's the literal GameBreaker: Scapular+Habit+either reroll item. By bringing yourself to half of a red heart, running into a level hazard (such as a torch, some spikes, or a Curse Room door), and then leaving and re-entering the room (to reset Scapular), you can generate infinite rerolls. The usual outcome tends to be gigantic tears firing in four directions that home in on enemies, pierce them, and follow Isaac around to just destroy everything, with Guppy's flies on top of that. If the player lucks out and gets a God Room for the floor, the potential for firing bullets ''backwards'' is possible. Where it becomes literal is that you can generate so many items that if you pick up too many spacebar
* In a mechanic example, Mom's Knife, Epic Fetus, and Brimstone, items which override most other forms of tears, can break the
* Three Pretty Flies. These can be acquired in a myriad of ways, including passive items, pills, and slot machines, and thus it's pretty reliably easy to get three of them in a run regardless of luck. With three, you become practically ''immune to all standard enemy projectiles'' (as well as flies). Suddenly a whole lot of things just can't hurt you and the only threats become contact damage, explosions, and beam-type attacks. Ever wanted to beat [[spoiler:Mom's Heart]], [[spoiler:It Lives]], and even ''[[spoiler:Issac]]'' without taking a single hit,
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* One of the new items is [[https://www.youtube.com/watch?v=XNYDFgE9EAM Monstro's Lung]]. By itself, it's a decent upgrade, giving you a charged vomit attack like that of its namesake. And then you get the [[StuffBlowingUp IPECAC]]. A combination of this with being able to fire multiple shots at once pretty much guarantees a OneHitKill on most enemies. And then you get Cricket's Body which causes the tears to split for even more explosions, then Fire Mind so each explosion [[NoKillLikeOverkill leaves behind a wall of fire]].
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* One of the new items is [[https://www.youtube.com/watch?v=XNYDFgE9EAM Monstro's Lung]]. By itself, it's a decent upgrade, giving you a charged vomit attack like that of its namesake. And then you get the [[StuffBlowingUp IPECAC]]. A combination of this with being able to fire multiple shots at once pretty much guarantees a OneHitKill on most enemies. And then you get Cricket's Body Body, which causes the tears to split for even more explosions, then Fire Mind so each explosion [[NoKillLikeOverkill leaves behind a wall of fire]].
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* And then there's the [[VideoGame/SuperMarioBros3 Gnawed Leaf]]. It makes Isaac immune to all damage when he stands still for two seconds, but that immunity goes away when he moves or shoots a tear. If you couple this with an item that does damage by itself without any player input (of which there are quite a few), it makes it impossible to lose under most circumstances. Especially if you have a level 3 or 4 Meat Boy or Bandage Girl or the Pinked Shears. Then, as long as no enemy is behind an obstacle, you just sit back and let Meat Boy, Bandage Girl, or Isaac's body kill everything. Even with just a damaging orbital it can trivialize a lot of rooms. And if you get Daddy Longlegs together with this, every room in the game (without a Host in it at least) turns into "Isaac WinsByDoingAbsolutelyNothing".
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* And then there's the [[VideoGame/SuperMarioBros3 Gnawed Leaf]]. It makes Isaac immune to all damage when he stands still for two seconds, but that immunity goes away when he moves or shoots a tear. If you couple this with an item that does damage by itself without any player input (of which there are quite a few), it makes it impossible to lose under most circumstances. Especially if you have a level 3 or 4 Meat Boy or Bandage Girl or the Pinked Shears. Then, as long as no enemy is behind an obstacle, you just sit back and let Meat Boy, Bandage Girl, or Isaac's body kill everything. Even with just a damaging orbital it can trivialize a lot of rooms. And if you get Daddy Longlegs together with this, every room in the game (without a Host in it at least) turns into "Isaac WinsByDoingAbsolutelyNothing". [[note]]''Repentance'' [[ObviousRulePatch nerfed this]] for the [[spoiler:Hush]] fight by giving him RegeneratingHealth that kicks in if he isn't attacked at all for several seconds while at low health, but everything else is still fair game.[[/note]]
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* The Ludovico Technique. On its face, it just turns your normal tears into a single, player-controlled permanent tear, which is useful but has its disadvantages. [[https://www.youtube.com/watch?v=gNuTqyc7nN4 Then you mix it with Brimstone.]] Instead of a mere tear, you get a giant ring of pure death that you can sweep across the screen to destroy all in your path. The same result can also be found by combining with [[EyeBeams Technology]] -- a crackling beam of energy turns into a circle of desolation. Then combine it with the Lost Contact, which makes your tears destroy enemies bullets. Congratulations, the enemy is now incapable of shooting you. Even [[spoiler:[[BulletHell Mega Satan]]]] can barely manage to sneak a bullet or two through. It does not, however, stop flame attacks. For even more hilarity, combine the normally useless Strange Attractor and your single bullet becomes an enemy-sucking black hole.
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* The Ludovico Technique. On its face, it just turns your normal tears into a single, player-controlled permanent tear, which is useful but has its disadvantages. [[https://www.youtube.com/watch?v=gNuTqyc7nN4 Then you mix it with Brimstone.]] Instead of a mere tear, you get a giant ring of pure death that you can sweep across the screen to destroy all in your path. The same result can also be found by combining with [[EyeBeams Technology]] -- a crackling beam of energy turns into a circle of desolation. Then combine it with the Lost Contact, which makes your tears destroy enemies enemies' bullets. Congratulations, the enemy is now incapable of shooting you. Even [[spoiler:[[BulletHell Mega Satan]]]] can barely manage to sneak a bullet or two through. It does not, however, stop flame attacks. For even more hilarity, combine the normally useless Strange Attractor and your single bullet becomes an enemy-sucking black hole.
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So good luck. You'll need them in order to take down hard bosses such as Mother, Delirium or The Beast. Especially with The Lost. Or its Tainted counterpart.
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So good luck. You'll need them in order to take down hard bosses such as Mother, Delirium Delirium, or The Beast. Especially with [[OneHitPointWonder The Lost. Lost]]. Or [[HarderThanHard its Tainted counterpart.counterpart]].
