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[[folder: Original Game]]
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* The UpdatedRerelease, ''Binding of Isaac: Rebirth'', lets you break the game in hilarious new ways! Combining Mom's Knife + Mom's Eye + Loki's Horns + Triple Shot + My Reflection + Tiny Planet could accurately be described as a "death blender", because this item combination ''(that Edmund McMillan says is so rare, you should probably go out and buy a lottery ticket after tearing through everything in your path)'' flings out three knives in each of the four cardinal directions (for a total of ''twelve knives'') that quickly spin around you before returning. [[http://bindingofisaac.com/post/82762252439/thats-not-a-knife It has to be seen to be believed.]]
** One of the new items shown off is [[https://www.youtube.com/watch?v=IW4CiNmfgL4 Monstro's Lung]]. By itself, it doesn't seem to be that bad, considering it just allows you to shoot multiple blood tears in one charged shot. And then you get the [[StuffBlowingUp IPECAC]]. A combination of this with being able to fire multiple shots at once pretty much guarantees a OneHitKill on most enemies. And then you get an unknown item that ''increases the amount of explosions''. And then you get another unknown item that '''''[[NoKillLikeOverkill leaves behind a wall of fire for each explosion]]'''''.
** One of the new items shown off is [[https://www.youtube.com/watch?v=IW4CiNmfgL4 Monstro's Lung]]. By itself, it doesn't seem to be that bad, considering it just allows you to shoot multiple blood tears in one charged shot. And then you get the [[StuffBlowingUp IPECAC]]. A combination of this with being able to fire multiple shots at once pretty much guarantees a OneHitKill on most enemies. And then you get an unknown item that ''increases the amount of explosions''. And then you get another unknown item that '''''[[NoKillLikeOverkill leaves behind a wall of fire for each explosion]]'''''.
[[/folder]]
[[folder: Rebirth]]
* Combining Mom's Knife + Mom's Eye + Loki's Horns + Triple Shot + My Reflection + Tiny Planet could accurately be described as a "death blender", because this item combination ''(that Edmund McMillan says is so rare, you should probably go out and buy a lottery ticket after tearing through everything in your path)'' flings out three knives in each of the four cardinal directions (for a total of ''twelve knives'') that quickly spin around you before returning. [[http://bindingofisaac.com/post/82762252439/thats-not-a-knife It has to be seen to be believed.]]
** One of the new items shown off is [[https://www.youtube.com/watch?v=IW4CiNmfgL4 Monstro's Lung]]. By itself, it doesn't seem to be that bad, considering it just allows you to shoot multiple blood tears in one charged shot. And then you get the [[StuffBlowingUp IPECAC]]. A combination of this with being able to fire multiple shots at once pretty much guarantees a OneHitKill on most enemies. And then you get an unknown item that ''increases the amount of explosions''. And then you get another unknown item that '''''[[NoKillLikeOverkill leaves behind a wall of fire for each explosion]]'''''.
[[folder: Rebirth]]
* Combining Mom's Knife + Mom's Eye + Loki's Horns + Triple Shot + My Reflection + Tiny Planet could accurately be described as a "death blender", because this item combination ''(that Edmund McMillan says is so rare, you should probably go out and buy a lottery ticket after tearing through everything in your path)'' flings out three knives in each of the four cardinal directions (for a total of ''twelve knives'') that quickly spin around you before returning. [[http://bindingofisaac.com/post/82762252439/thats-not-a-knife It has to be seen to be believed.]]
** One of the new items shown off is [[https://www.youtube.com/watch?v=IW4CiNmfgL4 Monstro's Lung]]. By itself, it doesn't seem to be that bad, considering it just allows you to shoot multiple blood tears in one charged shot. And then you get the [[StuffBlowingUp IPECAC]]. A combination of this with being able to fire multiple shots at once pretty much guarantees a OneHitKill on most enemies. And then you get an unknown item that ''increases the amount of explosions''. And then you get another unknown item that '''''[[NoKillLikeOverkill leaves behind a wall of fire for each explosion]]'''''.
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* And then there's the [[AnimalCrossing Gnawed Leaf]]. It makes Isaac immune to all damage when he stands still for two seconds, but that immunity goes away when he moves or shoots a tear. If you couple this with an item that does damage by itself without any player input, it makes it impossible to lose under most circumstances. Especially if you have a level 3 or 4 Meat Boy or Bandage Girl. Then, as long as no enemy is behind an obstacle, you just sit back and let Meat Boy or Bandage Girl kill everything.
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* And then there's the [[AnimalCrossing Gnawed Leaf]]. It makes Isaac immune to all damage when he stands still for two seconds, but that immunity goes away when he moves or shoots a tear. If you couple this with an item that does damage by itself without any player input, it makes it impossible to lose under most circumstances. Especially if you have a level 3 or 4 Meat Boy or Bandage Girl. Then, as long as no enemy is behind an obstacle, you just sit back and let Meat Boy or Bandage Girl kill everything. Even with just a damaging orbital it can trivialize a lot of rooms.
* Brimstone and the Ludevico Technique. Any player who knows what they do individually would expect Brimstone, mostly limited by the recharge time between deadly blasts, to synergize well with an ability to create a single permanent manually controlled tear. But most would expect it to create a segment of Brimstone, larger than a standard tear but not by that much. Instead, it creates a ''giant hoop of doom'' that takes up a substantial portion of the screen and can be swept across to destroy all in its path.
[[/folder]]
* Brimstone and the Ludevico Technique. Any player who knows what they do individually would expect Brimstone, mostly limited by the recharge time between deadly blasts, to synergize well with an ability to create a single permanent manually controlled tear. But most would expect it to create a segment of Brimstone, larger than a standard tear but not by that much. Instead, it creates a ''giant hoop of doom'' that takes up a substantial portion of the screen and can be swept across to destroy all in its path.
[[/folder]]
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* Two words: [[http://platinumgod.co.uk/dark-bum Dark Bum]]. It used to every Red Heart that it picks up into a Soul Heart. Considering that there are a ton of Red Heart drops throughout the game, this effectively ensured that you wouldn't be able to die unless you tried. It got nerfed into every 1.5 Red Hearts for a Soul Heart soon, however.
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* Two words: [[http://platinumgod.co.uk/dark-bum Dark Bum]]. It used to convert every Red Heart that it picks up into a Soul Heart. Considering that there are a ton of Red Heart drops throughout the game, this effectively ensured that you wouldn't be able to die unless you tried. It got nerfed into every 1.5 Red Hearts for a Soul Heart soon, however.but it is still considered pretty powerful.
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* Two words: [[http://platinumgod.co.uk/dark-bum Dark Bum]]. It used to every Red Heart that it picks up into a Soul Heart. Considering that there are a ton of Red Heart drops throughout the game, this effectively ensured that you wouldn't be able to die unless you tried. It got nerfed into every two Red Hearts for a Soul Heart soon, however.
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* Two words: [[http://platinumgod.co.uk/dark-bum Dark Bum]]. It used to every Red Heart that it picks up into a Soul Heart. Considering that there are a ton of Red Heart drops throughout the game, this effectively ensured that you wouldn't be able to die unless you tried. It got nerfed into every two 1.5 Red Hearts for a Soul Heart soon, however.
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* Two words: [[http://platinumgod.co.uk/dark-bum Dark Bum]]. It used to every Red Heart that it picks up into a Soul Heart. Considering that there are a ton of Red Heart drops throughout the game, this effectively ensured that you wouldn't be able to die unless you tried. It got nerfed into every two Red Hearts for a Soul Heart soon, however.
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* Two words: [[http://platinumgod.co.uk/dark-bum Dark Bum]]. It used to every Red Heart that it picks up into a Soul Heart. Considering that there are a ton of Red Heart drops throughout the game, this effectively ensured that you wouldn't be able to die unless you tried. It got nerfed into every two Red Hearts for a Soul Heart soon, however.however.
* And then there's the [[AnimalCrossing Gnawed Leaf]]. It makes Isaac immune to all damage when he stands still for two seconds, but that immunity goes away when he moves or shoots a tear. If you couple this with an item that does damage by itself without any player input, it makes it impossible to lose under most circumstances. Especially if you have a level 3 or 4 Meat Boy or Bandage Girl. Then, as long as no enemy is behind an obstacle, you just sit back and let Meat Boy or Bandage Girl kill everything.
* And then there's the [[AnimalCrossing Gnawed Leaf]]. It makes Isaac immune to all damage when he stands still for two seconds, but that immunity goes away when he moves or shoots a tear. If you couple this with an item that does damage by itself without any player input, it makes it impossible to lose under most circumstances. Especially if you have a level 3 or 4 Meat Boy or Bandage Girl. Then, as long as no enemy is behind an obstacle, you just sit back and let Meat Boy or Bandage Girl kill everything.
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* Two words: [[http://platinumgod.co.uk/dark-bum Dark Bum]]. It converts every Red Heart that it picks up into a Soul Heart. Considering that there are a ton of Red Heart drops throughout the game, this effectively ensures that you won't be able to die unless you try.
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* Two words: [[http://platinumgod.co.uk/dark-bum Dark Bum]]. It converts used to every Red Heart that it picks up into a Soul Heart. Considering that there are a ton of Red Heart drops throughout the game, this effectively ensures ensured that you won't wouldn't be able to die unless you try.tried. It got nerfed into every two Red Hearts for a Soul Heart soon, however.
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* Azazel, by himself, is considered to be overpowered by the fanbase [starting off with both flight and Brimstone (albeit, an extremely short ranged version)]. Add in the Tiny Planet as well, and you get a massive, 360 degree barrier of powerful, acidic blood on top of that.
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* Azazel, by himself, is considered to be overpowered by the fanbase [starting off with both flight and Brimstone (albeit, an extremely short ranged version)]. Add in the Tiny Planet as well, and you get a massive, 360 degree barrier of powerful, acidic blood on top of that.that.
* Two words: [[http://platinumgod.co.uk/dark-bum Dark Bum]]. It converts every Red Heart that it picks up into a Soul Heart. Considering that there are a ton of Red Heart drops throughout the game, this effectively ensures that you won't be able to die unless you try.
* Two words: [[http://platinumgod.co.uk/dark-bum Dark Bum]]. It converts every Red Heart that it picks up into a Soul Heart. Considering that there are a ton of Red Heart drops throughout the game, this effectively ensures that you won't be able to die unless you try.
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* And then there's the literal GameBreaker: Scapular+Habit+either reroll item. By bringing yourself to half of a red heart, running into a level hazard (such as a torch, some spikes, or a Curse Room door), and then leaving and re-entering the room (to reset Scapular), you can generate infinite rerolls. The usual outcome tends to be gigantic tears firing in four directions that home in on enemies, pierce them, and follow Isaac around to just destroy everything, with Guppy's flies on top of that. If the player lucks out and gets a God Room for the floor, the potential for firing bullets ''backwards'' is possible. Where it becomes literal is that you can generate so many items that if you pick up too many spacebar items the game just gives up and crashes.
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* And then there's the literal GameBreaker: Scapular+Habit+either reroll item. By bringing yourself to half of a red heart, running into a level hazard (such as a torch, some spikes, or a Curse Room door), and then leaving and re-entering the room (to reset Scapular), you can generate infinite rerolls. The usual outcome tends to be gigantic tears firing in four directions that home in on enemies, pierce them, and follow Isaac around to just destroy everything, with Guppy's flies on top of that. If the player lucks out and gets a God Room for the floor, the potential for firing bullets ''backwards'' is possible. Where it becomes literal is that you can generate so many items that if you pick up too many spacebar items the game just gives up and crashes.crashes.
* Azazel, by himself, is considered to be overpowered by the fanbase [starting off with both flight and Brimstone (albeit, an extremely short ranged version)]. Add in the Tiny Planet as well, and you get a massive, 360 degree barrier of powerful, acidic blood on top of that.
* Azazel, by himself, is considered to be overpowered by the fanbase [starting off with both flight and Brimstone (albeit, an extremely short ranged version)]. Add in the Tiny Planet as well, and you get a massive, 360 degree barrier of powerful, acidic blood on top of that.
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** One of the new items shown off is [[https://www.youtube.com/watch?v=IW4CiNmfgL4 Monstro's Lung]]. By itself, it doesn't seem to be that bad, considering it just allows you to shoot multiple blood tears in one charged shot. And then you get the [[StuffBlowingUp IPECAC]]. A combination of this with being able to fire multiple shots at once pretty much guarantees a OneHitKill on most enemies. And then you get an unknown item that ''increases the amount of explosions''. And then you get another unknown item that '''''[[NoKillLikeOverkill leaves behind a wall of fire for each explosion]]'''''.
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** Master nothing. Add Bobby-Bomb (homing bombs), and who needs aiming? Additional items like Ouija Board (bombs pass through walls), flight (so you can too), and Mr. Mega (HUGE bomb) makes the entire game a cakewalk. Even [[spoiler:Isaac]] goes down like nothing.
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** Master nothing. Add Bobby-Bomb (homing bombs), and who needs aiming? Additional items like Ouija Board (bombs pass through walls), flight (so you can too), and Mr. Mega (HUGE bomb) makes the entire game a cakewalk. Even [[spoiler:Isaac]] goes down like nothing. The best part about these extras? Collecting Dr. Fetus actually ''rigs the item rooms'', making it more likely that Bobby-Bomb and Mr. Mega will appear.
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* The UpdatedRerelease, ''Binding of Isaac: Rebirth'', lets you break the game in hilarious new ways! Combining Mom's Knife + Mom's Eye + Loki's Horns + Triple Shot + My Reflection + Tiny Planet could accurately be described as a "death blender", because this item combination ''(that Edmund McMillan says is so rare, you should probably go out and buy a lottery ticket after tearing through everything in your path)'' flings out three knives in each of the four cardinal directions (for a total of ''twelve knives'') that quickly spin around you before returning. [[http://bindingofisaac.com/post/82762252439/thats-not-a-knife It has to be seen to be believed.]]
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* The Guppy transformation. It requires touching any three of Guppy's Paw, Guppy's Head, Guppy's Tail, and the Dead Cat items, meaning that you'll likely have to spend a lot of heart containers to transform unless you get very lucky with Red Chests. The transformation itself grants flight and causes every tear that hits to spawn a kamikaze fly. These flies deal twice as much damage as the player's tears, and one is spawned for ANY tear that hits. Add in any tear-firing familiars (or just a high fire rate), and just watch as anything before you gets cut down by an army of flies.
* The UpdatedRerelease, ''Binding of Isaac: Rebirth'', lets you break the game in hilarious new ways! Combining Mom's Knife + Mom's Eye + Loki's Horns + Triple Shot + My Reflection + Tiny Planet could accurately be described as a "death blender", because this item combination ''(that Edmund McMillan says is so rare, you should probably go out and buy a lottery ticket after tearing through everything in your path)'' flings out three knives in each of the four cardinal directions (for a total of ''twelve knives'') that quickly spin around you before returning. [[http://bindingofisaac.com/post/82762252439/thats-not-a-knife It has to be seen to be believed.]]]]
* And then there's the literal GameBreaker: Scapular+Habit+either reroll item. By bringing yourself to half of a red heart, running into a level hazard (such as a torch, some spikes, or a Curse Room door), and then leaving and re-entering the room (to reset Scapular), you can generate infinite rerolls. The usual outcome tends to be gigantic tears firing in four directions that home in on enemies, pierce them, and follow Isaac around to just destroy everything, with Guppy's flies on top of that. If the player lucks out and gets a God Room for the floor, the potential for firing bullets ''backwards'' is possible. Where it becomes literal is that you can generate so many items that if you pick up too many spacebar items the game just gives up and crashes.
* The UpdatedRerelease, ''Binding of Isaac: Rebirth'', lets you break the game in hilarious new ways! Combining Mom's Knife + Mom's Eye + Loki's Horns + Triple Shot + My Reflection + Tiny Planet could accurately be described as a "death blender", because this item combination ''(that Edmund McMillan says is so rare, you should probably go out and buy a lottery ticket after tearing through everything in your path)'' flings out three knives in each of the four cardinal directions (for a total of ''twelve knives'') that quickly spin around you before returning. [[http://bindingofisaac.com/post/82762252439/thats-not-a-knife It has to be seen to be believed.
* And then there's the literal GameBreaker: Scapular+Habit+either reroll item. By bringing yourself to half of a red heart, running into a level hazard (such as a torch, some spikes, or a Curse Room door), and then leaving and re-entering the room (to reset Scapular), you can generate infinite rerolls. The usual outcome tends to be gigantic tears firing in four directions that home in on enemies, pierce them, and follow Isaac around to just destroy everything, with Guppy's flies on top of that. If the player lucks out and gets a God Room for the floor, the potential for firing bullets ''backwards'' is possible. Where it becomes literal is that you can generate so many items that if you pick up too many spacebar items the game just gives up and crashes.
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The luck stat or the lucky foot has no effect on item drops
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* Cain, due to the fact that he starts out with The Lucky Foot. By having an item that boosts luck, he is MUCH more likely to get any combination of items listed here.
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Elaborating on this because the combo simply kicks ass.
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* Speaking of Polyphemus, it synergises insanely with Brimstone. See DifficultButAwesome.
** Or with any weapon where the tears stat matters little (Dr Fetus, Ipecac, Tech2, Mom's Knife, etc)
** Or with any weapon where the tears stat matters little (Dr Fetus, Ipecac, Tech2, Mom's Knife, etc)
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* Speaking of Polyphemus, it synergises insanely with Brimstone. See DifficultButAwesome.
Polybrim, as it is sometimes called, deals insane amounts of damage (that can be more than doubled via the Brimsnap glitch) and its only draw, the long charging time, can be bypassed, at least for one shot, by charging it up before entering a room with enemies. With this combo, you can one-shot all enemies ''and most bosses'' within seconds.
**Or Polyphemus also synergises well with any weapon where the tears stat matters little (Dr Fetus, Ipecac, Tech2, Mom's Knife, etc)
**
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* If you can, getting two or more "baby" items (Brother Bobby, Sister Maggy, etc...) allows for a ton of damage to be done, especially if you can get variations with special abilities.
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* If you can, getting two or more "baby" items (Brother Bobby, Sister Maggy, etc...) allows for a ton of damage to be done, especially if you can get variations with special abilities.abilities.
* The UpdatedRerelease, ''Binding of Isaac: Rebirth'', lets you break the game in hilarious new ways! Combining Mom's Knife + Mom's Eye + Loki's Horns + Triple Shot + My Reflection + Tiny Planet could accurately be described as a "death blender", because this item combination ''(that Edmund McMillan says is so rare, you should probably go out and buy a lottery ticket after tearing through everything in your path)'' flings out three knives in each of the four cardinal directions (for a total of ''twelve knives'') that quickly spin around you before returning. [[http://bindingofisaac.com/post/82762252439/thats-not-a-knife It has to be seen to be believed.]]
* The UpdatedRerelease, ''Binding of Isaac: Rebirth'', lets you break the game in hilarious new ways! Combining Mom's Knife + Mom's Eye + Loki's Horns + Triple Shot + My Reflection + Tiny Planet could accurately be described as a "death blender", because this item combination ''(that Edmund McMillan says is so rare, you should probably go out and buy a lottery ticket after tearing through everything in your path)'' flings out three knives in each of the four cardinal directions (for a total of ''twelve knives'') that quickly spin around you before returning. [[http://bindingofisaac.com/post/82762252439/thats-not-a-knife It has to be seen to be believed.]]
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* Dollar (max cash) + Money Is Power [[ExactlyWhatItSaysOnTheTin (boosts damage proportional to money total)]]= Total Annhilation.
* Cain, due to the fact that he starts out with The Lucky Foot. By having an item that boosts luck, he is MUCH more likely to get any combination of items listed here.
* Cain, due to the fact that he starts out with The Lucky Foot. By having an item that boosts luck, he is MUCH more likely to get any combination of items listed here.
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** He's even more broken during the "Meat 4 Evar" challenge; the challenge starts you with 1 fully assembled Meatboy and allows you to ''build another one.''
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* Judas, if he finds Blood of the Martyr, will flatten the early game and have a distinct advantage through the final floors. His starting item, the Book of Belial, already stacks with Judas's inherent 4/3 damage multiplier, but with the Blood of the Martyr, the Book of Belial multiplies his damage by 1.5 ''in addition'' to its effects. Mitigated slightly because other 1.5 multipliers will cancel the active effects, it still can turn him into the ultimate GlassCannon.
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* Judas, if he finds Blood of the Martyr, will flatten the early game and have a distinct advantage through the final floors. His starting item, the Book of Belial, already stacks with Judas's inherent 4/3 damage multiplier, but with the Blood of the Martyr, the Book of Belial multiplies his damage by 1.5 ''in addition'' to its effects. Mitigated slightly because other 1.5 multipliers will cancel the active effects, it still can turn him into the ultimate GlassCannon.GlassCannon.
* If you can, getting two or more "baby" items (Brother Bobby, Sister Maggy, etc...) allows for a ton of damage to be done, especially if you can get variations with special abilities.
* If you can, getting two or more "baby" items (Brother Bobby, Sister Maggy, etc...) allows for a ton of damage to be done, especially if you can get variations with special abilities.
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** Especially if you consider that the Blood Bag's cooldown is slightly shorter than the MercyInvincibility. Which means that, with a single half-heart (on the first 6 floors), you can get 3-4 coins, which in turn can give you 1-2 hearts on average. So, even without a slot machine, you can get infinite coins and hearts.
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** Especially if you consider that the Blood Bag's cooldown is slightly shorter than the MercyInvincibility. Which means that, with a single half-heart (on the first 6 floors), you can use it twice and get 3-4 coins, coins on average, which in turn can give you 1-2 hearts on average. So, even without a slot machine, you can get infinite coins and hearts.
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** Especially if you consider that the Blood Bag's cooldown is slightly shorter than the MercyInvincibility. Which means that, with a single half-heart (on the first 6 floors), you can get 3-4 coins, which in turn can give you 1-2 hearts on average. So, even without a slot machine, you can get infinite coins and hearts.
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* Polyphemus+Mom's Knife, [[http://www.youtube.com/watch?v=uKEhs2Di9Oc&feature=plcp Northernlion approved (skip to 45:00)]] (for those who didn't watch the video, it allowed him to take down [[spoiler:[[DamageSpongeBoss Blue]] [[BulletHell Baby]]]] in a few seconds).
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* Polyphemus+Mom's Knife, [[http://www.youtube.com/watch?v=uKEhs2Di9Oc&feature=plcp [[http://youtu.be/uKEhs2Di9Oc?t=44m55s Northernlion approved (skip to 45:00)]] approved]] (for those who didn't watch the video, it allowed him to take down [[spoiler:[[DamageSpongeBoss Blue]] [[BulletHell Baby]]]] in a few seconds).
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* Technology (piercing shots with unlimited range) + Chocolate Milk (charge shots) = Win [[http://www.youtube.com/watch?v=Si-4xJsPOxc (Northernlion approved, skip to 26:00).]]
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* Technology (piercing shots with unlimited range) + Chocolate Milk (charge shots) = Win [[http://www.youtube.com/watch?v=Si-4xJsPOxc [[http://youtu.be/Si-4xJsPOxc?t=26m1s (Northernlion approved, skip to 26:00).approved).]]
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* Not too game breaking, but have the bloody penny on hand when you find a blood bank.
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* Not too game breaking, Finding the Bloody Penny allows one to convert money drops into red hearts. Blood donation machines do the reverse, but have can pay out nickels or dimes. In tandem, this can produce infinite money and consumable health for a floor. If found in an arcade, the bloody penny on hand when you find a combo can be exploited for infinite keys, bombs and Skatole. Even if the blood bank.donation machine happens pay out, it will droop the Blood Bag, which fills heart containers and gives an HP up, or the IV Bag, which acts as a portable, more reliable blood donation machine.
* Judas, if he finds Blood of the Martyr, will flatten the early game and have a distinct advantage through the final floors. His starting item, the Book of Belial, already stacks with Judas's inherent 4/3 damage multiplier, but with the Blood of the Martyr, the Book of Belial multiplies his damage by 1.5 ''in addition'' to its effects. Mitigated slightly because other 1.5 multipliers will cancel the active effects, it still can turn him into the ultimate GlassCannon.
* Judas, if he finds Blood of the Martyr, will flatten the early game and have a distinct advantage through the final floors. His starting item, the Book of Belial, already stacks with Judas's inherent 4/3 damage multiplier, but with the Blood of the Martyr, the Book of Belial multiplies his damage by 1.5 ''in addition'' to its effects. Mitigated slightly because other 1.5 multipliers will cancel the active effects, it still can turn him into the ultimate GlassCannon.
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** TakenUpToEleven if you buy Guppy's Paw with those new heart containers. Guppy's Paw destroys one heart container in exchange for three soul/spirit hearts. Tough choice, right? Not if you already have 5 or 6 heart containers. Use up four or five of them, and that's an instant 12 or 15 spirit hearts!
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** TakenUpToEleven Taken UpToEleven if you buy Guppy's Paw with those new heart containers. Guppy's Paw destroys one heart container in exchange for three soul/spirit hearts. Tough choice, right? Not if you already have 5 or 6 heart containers. Use up four or five of them, and that's an instant 12 or 15 spirit hearts!
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* Polythemus+Mom's Knife, [[http://www.youtube.com/watch?v=uKEhs2Di9Oc&feature=plcp Northernlion approved (skip to 45:00)]] (for those who didn't watch the video, it allowed him to take down [[spoiler:[[DamageSpongeBoss Blue]] [[BulletHell Baby]]]] in a few seconds).
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* Polythemus+Mom's Polyphemus+Mom's Knife, [[http://www.youtube.com/watch?v=uKEhs2Di9Oc&feature=plcp Northernlion approved (skip to 45:00)]] (for those who didn't watch the video, it allowed him to take down [[spoiler:[[DamageSpongeBoss Blue]] [[BulletHell Baby]]]] in a few seconds).
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* Scratch that, WotL brings in the [=D20=] from ''DungeonsAndDragons'' fame. It rerolls every single pick up in the room, so you can reroll marginally useful items like pennies and half hearts and get pills, soul hearts, faith hearts, tarot and poker cards, nickels, dimes, the whole spectrum of trinkets and chests with several pickups inside, possibly even a powerup. Chances of getting great stuff are low per pickup, but then you go to an Arcade and pile up a huge stack of half hearts, keys, etc from the machines to polymorph at once. Good thing it has a 6 room recharge...
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* Scratch that, WotL [=WotL=] brings in the [=D20=] from ''DungeonsAndDragons'' fame. It rerolls every single pick up in the room, so you can reroll marginally useful items like pennies and half hearts and get pills, soul hearts, faith hearts, tarot and poker cards, nickels, dimes, the whole spectrum of trinkets and chests with several pickups inside, possibly even a powerup. Chances of getting great stuff are low per pickup, but then you go to an Arcade and pile up a huge stack of half hearts, keys, etc from the machines to polymorph at once. Good thing it has a 6 room recharge...
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** Becomes even more powerful if you have A Pony. If you use the pony's charge attack, but not choose a direction, you will be completly invencible, so you can aim Epic Fetus's missiles with the mouse and clear any room with impunity.
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** Becomes even more powerful if you have A Pony. If you use the pony's charge attack, but not choose a direction, you will be completly invencible, completely invincible, so you can aim Epic Fetus's missiles with the mouse and clear any room with impunity.
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* The Ankh. who revives you as [[spoiler:???/Blue Baby]] if you die. In terms of Steam Achievements and game content, you ARE [[spoiler:him]]. This nullifies half of the challenge of beating the game with [[spoiler:him]] if you get the Ankh on a lucky run with another character and die on purpose. It also makes it entirely possible to unlock the Forget Me Now and the Rainbow Baby before obtaining the D6.
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* The Ankh. who Ankh, which revives you as [[spoiler:???/Blue Baby]] if you die. In terms of Steam Achievements and game content, you ARE [[spoiler:him]]. This nullifies half of the challenge of beating the game with [[spoiler:him]] if you get the Ankh on a lucky run with another character and die on purpose. It also makes it entirely possible to unlock the Forget Me Now and the Rainbow Baby before obtaining the D6.
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** Sadly, this one seems to be patched.
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** Sadly, this one seems to be patched.patched.
* Not too game breaking, but have the bloody penny on hand when you find a blood bank.
* Not too game breaking, but have the bloody penny on hand when you find a blood bank.
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* Sacred Heart. It is basically a slightly weaker Polyphemus with a faster fire rate, plus the ability to home in on enemies. Upon taking it, Sacred Heart also instantly restores you to max health plus an additional soul heart. Unlike Polyphemus, taking Mutant Spider with Sacred Heart will not reduce Sacred Heart's damage, making Mutant Spider + Sacred Heart a very viable combo.
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* Technology (piercing shots with unlimited range) + Chocolate Milk (charge shots) = Win [[http://www.youtube.com/watch?v=Si-4xJsPOxc (Northernlion approved).]]
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* Technology (piercing shots with unlimited range) + Chocolate Milk (charge shots) = Win [[http://www.youtube.com/watch?v=Si-4xJsPOxc (Northernlion approved).approved, skip to 26:00).]]
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* Polythemus+Mom's Knife, [[http://www.youtube.com/watch?v=uKEhs2Di9Oc&feature=plcp Northernlion approved]] (for those who didn't watch the video, it allowed him to take down [[spoiler:[[DamageSpongeBoss Blue]] [[BulletHell Baby]]]] in a few seconds.
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* Polythemus+Mom's Knife, [[http://www.youtube.com/watch?v=uKEhs2Di9Oc&feature=plcp Northernlion approved]] approved (skip to 45:00)]] (for those who didn't watch the video, it allowed him to take down [[spoiler:[[DamageSpongeBoss Blue]] [[BulletHell Baby]]]] in a few seconds.seconds).
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*** Additionally, if you use a fully charged item, the 3 charges per room limit ''resets''. This means entering a room with 3 charges, waiting to use the item and waiting ''again'' with an enemy still present will yield a total of six bars per room, no 9-volt required. Find a room with an easy enemy (like a single doppelganger in the womb or utero) and your supply of bombs can be entirely converted to a supply of blue hearts by combining the battery with a nail or book of revelations. With Ipecac, fetus in a jar or epic fetus, you can create as many blue hearts as you have the patience to generate!!!
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*** Additionally, if you use a fully charged item, the 3 charges per room limit ''resets''. This means entering a room with 3 charges, waiting to use the item and waiting ''again'' with an enemy still present will yield a total of six bars per room, no 9-volt required. Find a room with an easy enemy (like a single doppelganger in the womb or utero) and your supply of bombs can be entirely converted to a supply of blue hearts by combining the battery with a nail or book of revelations. With Ipecac, fetus in a jar or epic fetus, you can create as many blue hearts as you have the patience to generate!!!generate!
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** Flight. It lets you fly over pits, bypassing the challenges many rooms create with limited space, and prevents numerous enemy types from messing with you. This makes fighting [[DemonicSpiders the Knights]] a LOT easier. The Ladder works as a poor substitute, letting you pass over a pit if it's only a square long in the direction you're going, but is almost as useful and can be found early on consistently.
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* Liberty Cap for [[spoiler:???]]. The Liberty Cap, whenever the player enters a room, gives the effect of a random mushroom (Mini Mushroom or both Odd Mushrooms). One of the Odd Mushrooms adds a heart container. When the Liberty Cap uses that effect, the heart container goes away after the player leaves the room. However, for [[spoiler:???]], the mushroom adds one spirit heart. This spirit heart doesn't go away after leaving the room, so the player can just walk back and forth between two rooms and watch his spirit hearts go way up after a while.
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* Liberty Cap for [[spoiler:???]]. The Liberty Cap, whenever the player enters a room, gives the effect of a random mushroom (Mini Mushroom or both Odd Mushrooms). One of the Odd Mushrooms adds a heart container. When the Liberty Cap uses that effect, the heart container goes away after the player leaves the room. However, for [[spoiler:???]], the mushroom adds one spirit heart. This spirit heart doesn't go away after leaving the room, so the player can just walk back and forth between two rooms and watch his spirit hearts go way up after a while.while.
** Sadly, this one seems to be patched.
** Sadly, this one seems to be patched.
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Note that any game breaker may be balanced simply being hard to find/get. Due to the random nature of the game there may not be a single one listed during a run, but also due to the difficulty the game has it may be required to have at least one of the game breakers to simply get through. Put simply: despite the number of game breakers you may not find one, or they may be balanced during the later levels of the game.
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** Not only that, but it can even reroll Troll Bombs. So basically, you just have to either use the Tower tarot card or when fighting War or Pride, you can use it to change all the Troll Bombs they summon into items.
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* The X-Ray glasses. As noted above, they synergize with the battery for unlimited item charges. On their own, not only do they reveal secret room entrances, they also open them for you without needing bombs. Bombs are very important in the early game. They can also save you keys to enter a shop or item room if it happens to border a secret room.
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* The X-Ray glasses. As noted above, they synergize with the battery for unlimited item charges. On their own, not only do they reveal secret room entrances, they also open them for you without needing bombs. Bombs are very important in the early game. They can also save you keys to enter a shop or item room if it happens to border a secret room.room.
* Liberty Cap for [[spoiler:???]]. The Liberty Cap, whenever the player enters a room, gives the effect of a random mushroom (Mini Mushroom or both Odd Mushrooms). One of the Odd Mushrooms adds a heart container. When the Liberty Cap uses that effect, the heart container goes away after the player leaves the room. However, for [[spoiler:???]], the mushroom adds one spirit heart. This spirit heart doesn't go away after leaving the room, so the player can just walk back and forth between two rooms and watch his spirit hearts go way up after a while.
* Liberty Cap for [[spoiler:???]]. The Liberty Cap, whenever the player enters a room, gives the effect of a random mushroom (Mini Mushroom or both Odd Mushrooms). One of the Odd Mushrooms adds a heart container. When the Liberty Cap uses that effect, the heart container goes away after the player leaves the room. However, for [[spoiler:???]], the mushroom adds one spirit heart. This spirit heart doesn't go away after leaving the room, so the player can just walk back and forth between two rooms and watch his spirit hearts go way up after a while.
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There are a lot of ways to break this game.
* Meatboy at level 3 and beyond. He chases down enemies with a cheery smile and blocks bullets. It takes a while to get him, but he'll wipe out most enemies without your input. On the other hand, he can also sometimes push bombs away from where you place them.
* The Battery, which regenerates three points on a spacebar item if you wait in a room with enemies long enough. This means a charged item every two rooms, even on the longest charging items. If you can blow the doors open or exit through a secret door (x-ray glasses, for example), it's effectively an infinite charge. Combine this with the 9-volt (plus two charge points automatically) and it works for every single room. Now combine it with My Little Unicorn for invincibility, Prayer Card for limitless health, or a myriad of other items for all sorts of awesome abilities.
*** Additionally, if you use a fully charged item, the 3 charges per room limit ''resets''. This means entering a room with 3 charges, waiting to use the item and waiting ''again'' with an enemy still present will yield a total of six bars per room, no 9-volt required. Find a room with an easy enemy (like a single doppelganger in the womb or utero) and your supply of bombs can be entirely converted to a supply of blue hearts by combining the battery with a nail or book of revelations. With Ipecac, fetus in a jar or epic fetus, you can create as many blue hearts as you have the patience to generate!!!
** And then there's the Habit upgrade, which lets you trade damage for three bars worth of charges.
** Flight. It lets you fly over pits, bypassing the challenges many rooms create with limited space, and prevents numerous enemy types from messing with you. This makes fighting [[DemonicSpiders the Knights]] a LOT easier. The Ladder works as a poor substitute, letting you pass over a pit if it's only a square long in the direction you're going, but is almost as useful and can be found early on consistently.
** Better yet, flight plus the Ouija board (which lets you shoot through rocks), or the Spirit of the Night item which combines them. Projectiles and most enemies will not be able to touch you if you're floating over an obstacle, and their projectiles can't penetrate the rocks, but yours will still hit them. You could theoretically beat some bosses (like Chad) and many other rooms by hovering over a rock and holding down the fire button.
* Mom's Bra or the Book of Shadows can basically win a room by themselves or put the serious hurt on a boss during their duration and can be used once every three rooms. The Book of Shadows gets a special mention because if you have Poison Touch from The Virus to go with it, you've essentially got My Little Unicorn with a faster recharge rate. Mom's Bra (or Mom's Contacts, though not as reliably) ''does'' protect you from collision damage, only with it the bosses won't be running away while you drain two thirds of their lifebar with The Virus.
* If you've mastered fighting Wrath's ability to kick bombs, Dr. Fetus becomes this, giving you the ability to shoot ''infinite bombs.''
** Master nothing. Add Bobby-Bomb (homing bombs), and who needs aiming? Additional items like Ouija Board (bombs pass through walls), flight (so you can too), and Mr. Mega (HUGE bomb) makes the entire game a cakewalk. Even [[spoiler:Isaac]] goes down like nothing.
** If you know how to use it, then the base skill can become this. If you can avoid enemies and get them hit by the bombs, then you can kill every enemy in the game with basic bombs.
** That all pales in comparison to the Fetus+Bra combo. Activate the bra and fling bombs from the proper distance for the entire duration, and almost every boss in the game (even Mom) can be killed before it even gets an attack off. It'll even take half the life off of the Cathedral boss if you have four power or so, rather less the mega bomb and/or maximum power. And unlike a lot of boss combos, it's also ridiculously effective in the levels too, since the fetus all but guarantees that the stun time is enough to dispatch every enemy in the room without risk once every three rooms.
** It's not only useful in battles; you will essentially get a free secret room and super secret room each level if you take the time to look for them, which can have a massive impact depending on what they contain.
** Dr Fetus + Remote Detonator. Not only do you have an unlimited supply of bombs at your disposal, but the remote detonator gives you the ability to ''time'' your bombs' explosions; effectively negating the Dr. Fetus item's greatest downfall.
* The Nail. When used, it gives a spirit heart, increases damage, and lets player walk over rocks among with the other benefits. This was even more broken in earlier versions, where it gave ''two'' spirit hearts.
* Technology (piercing shots with unlimited range) + Chocolate Milk (charge shots) = Win [[http://www.youtube.com/watch?v=Si-4xJsPOxc (Northernlion approved).]]
* Steam Sale (everything in shops half off) + dollar (maximized cash) = shops being very useful.
* After the Halloween update, Brimstone. It replaces your previous attack with an extremely powerful and wide beam which can fire through obstacles but must be charged beforehand. Properly mastered, you'll be a killing machine. Get damage powerups and it becomes even more awesome.
* Whore of Babylon [[DifficultButAwesome (the item that puts you in a One Winged Angel state which maxes out your attack so long as, regular heart-wise, you're only a single hit away from death)]] is this when used by [[spoiler:Blue Baby]]. As he has no regular hearts (and can never get any), the effect is permanent.
* Mom's Knife + Mom's Contact. Mom's knife does rapid high-powered damage. Mom's contact has a chance of turning the target to stone per hit. Rapid hit + stone chance = stone enemy. Now, keep in mind Isaac can then just walk up to said immobile enemy with the knife, which will continue to do rapid damage plus turn them back to stone -- so only enemies with backup will survive once that first stone hit kicks in.
* Mom's Bottle of Pills + PHD. PHD removes all negative effect pills (damage, stat reduction), while the bottle lets you generate, at minimum, one pill every six rooms (with enemies). You may occasionally get neutral pills like Bombs Are Key, but (especially if you get it early) over time you're guaranteed to get a lot of tear/damage/range boosts, especially in the bigger levels. You can even use it with the Battery (plus [[SerialEscalation the 9-Volt]]) to speed up your stat-increasing even more! If you're playing as Cain, you don't even need the PHD, since his innate Lucky Foot pill has the same effect.
* The Prayer Card is the Game Breaker to end all Game Breakers. Once per six rooms, it allows you to create half of a Prayer/Eternal Heart. If you finish the stage with one of these, or manage to obtain a second one, you get a full heart container. To put it simply, if you're skilled, it lets you pull entirely new heart containers straight out of your ass, ''for free'', every twelve rooms. It gets even more hideously broken if you manage to get the Battery with it, giving you the opportunity to give you a new heart container ''every two rooms''. Naturally, this tends to make you able to completely buy out the Devil Room shops, making you an unstoppable force with insane power and health that doesn't even fit on the screen.
** TakenUpToEleven if you buy Guppy's Paw with those new heart containers. Guppy's Paw destroys one heart container in exchange for three soul/spirit hearts. Tough choice, right? Not if you already have 5 or 6 heart containers. Use up four or five of them, and that's an instant 12 or 15 spirit hearts!
* Technology 2 (which shoots a laser that is [[DeathOfAThousandCuts weak as all hell but hits constantly]]). Because it hits very quickly, it will almost always activate items with on-hit properties such as Mom's Contact (which gives your shots a chance to freeze enemies), The Mulligan (which gives you a chance to spawn a kamikaze attack fly whenever you shoot an enemy) or the Common Cold (Which gives shots a chance to poison).
** It's even more overpowered with Polythemus, which does ridiculous damage but sets tears to minimum. It's balanced, but with Technology 2 will down all bosses in seconds and one shot enemies.
* Speaking of Polyphemus, it synergises insanely with Brimstone. See DifficultButAwesome.
** Or with any weapon where the tears stat matters little (Dr Fetus, Ipecac, Tech2, Mom's Knife, etc)
* The Nun's Habit charge your item bar whenever you are hit. Doesn't seems so gamebreaking so far? [[http://youtu.be/1JSaG3zw38E?t=13m25s Well...]]
* The Crystal Ball is yet another item which breaks the game wide open when combined with the battery. Even on its own, however, it's rather overpowered: once every six rooms, you may reveal the map (if you have not done so already) AND receive either a spirit heart or an extra tarot card. This makes the final few levels of the game much quicker.
* Polythemus+Mom's Knife, [[http://www.youtube.com/watch?v=uKEhs2Di9Oc&feature=plcp Northernlion approved]] (for those who didn't watch the video, it allowed him to take down [[spoiler:[[DamageSpongeBoss Blue]] [[BulletHell Baby]]]] in a few seconds.
* The [=D6=] allows you to reroll powerups. Combine this with the battery for half charge per room and a room with green bomb spitters to blow the doors open, and you can reroll (tediously) until you get what you want.
* Scratch that, WotL brings in the [=D20=] from ''DungeonsAndDragons'' fame. It rerolls every single pick up in the room, so you can reroll marginally useful items like pennies and half hearts and get pills, soul hearts, faith hearts, tarot and poker cards, nickels, dimes, the whole spectrum of trinkets and chests with several pickups inside, possibly even a powerup. Chances of getting great stuff are low per pickup, but then you go to an Arcade and pile up a huge stack of half hearts, keys, etc from the machines to polymorph at once. Good thing it has a 6 room recharge...
* Epic Fetus, which launches guided missiles almost as fast as Dr. Fetus launches unguided bombs. If you get this, the only thing likely to kill you other than the final boss is hilarious incompetence. Perhaps in recognition of the fact, the unlock image has the fetus giving the finger while missiles fall all around it.
** Becomes even more powerful if you have A Pony. If you use the pony's charge attack, but not choose a direction, you will be completly invencible, so you can aim Epic Fetus's missiles with the mouse and clear any room with impunity.
* The Scapular gives you a soul heart one per room once you are on the last half heart (normal) or, on [[spoiler:???]], when you lose your last heart. Done right, you can use this to get lots of money from a heart donation machine by going to low health, exiting the room and going back after getting the extra soul heart, and use the machine twice, once in later levels, giving you another one. Exit, repeat. It also helps that it's basically regenerating health, allowing you more error. That ratio for error is small, but it's better than not being able to make error, but that part isn't really breaking.
* The Ankh. who revives you as [[spoiler:???/Blue Baby]] if you die. In terms of Steam Achievements and game content, you ARE [[spoiler:him]]. This nullifies half of the challenge of beating the game with [[spoiler:him]] if you get the Ankh on a lucky run with another character and die on purpose. It also makes it entirely possible to unlock the Forget Me Now and the Rainbow Baby before obtaining the D6.
* The X-Ray glasses. As noted above, they synergize with the battery for unlimited item charges. On their own, not only do they reveal secret room entrances, they also open them for you without needing bombs. Bombs are very important in the early game. They can also save you keys to enter a shop or item room if it happens to border a secret room.
* Meatboy at level 3 and beyond. He chases down enemies with a cheery smile and blocks bullets. It takes a while to get him, but he'll wipe out most enemies without your input. On the other hand, he can also sometimes push bombs away from where you place them.
* The Battery, which regenerates three points on a spacebar item if you wait in a room with enemies long enough. This means a charged item every two rooms, even on the longest charging items. If you can blow the doors open or exit through a secret door (x-ray glasses, for example), it's effectively an infinite charge. Combine this with the 9-volt (plus two charge points automatically) and it works for every single room. Now combine it with My Little Unicorn for invincibility, Prayer Card for limitless health, or a myriad of other items for all sorts of awesome abilities.
*** Additionally, if you use a fully charged item, the 3 charges per room limit ''resets''. This means entering a room with 3 charges, waiting to use the item and waiting ''again'' with an enemy still present will yield a total of six bars per room, no 9-volt required. Find a room with an easy enemy (like a single doppelganger in the womb or utero) and your supply of bombs can be entirely converted to a supply of blue hearts by combining the battery with a nail or book of revelations. With Ipecac, fetus in a jar or epic fetus, you can create as many blue hearts as you have the patience to generate!!!
** And then there's the Habit upgrade, which lets you trade damage for three bars worth of charges.
** Flight. It lets you fly over pits, bypassing the challenges many rooms create with limited space, and prevents numerous enemy types from messing with you. This makes fighting [[DemonicSpiders the Knights]] a LOT easier. The Ladder works as a poor substitute, letting you pass over a pit if it's only a square long in the direction you're going, but is almost as useful and can be found early on consistently.
** Better yet, flight plus the Ouija board (which lets you shoot through rocks), or the Spirit of the Night item which combines them. Projectiles and most enemies will not be able to touch you if you're floating over an obstacle, and their projectiles can't penetrate the rocks, but yours will still hit them. You could theoretically beat some bosses (like Chad) and many other rooms by hovering over a rock and holding down the fire button.
* Mom's Bra or the Book of Shadows can basically win a room by themselves or put the serious hurt on a boss during their duration and can be used once every three rooms. The Book of Shadows gets a special mention because if you have Poison Touch from The Virus to go with it, you've essentially got My Little Unicorn with a faster recharge rate. Mom's Bra (or Mom's Contacts, though not as reliably) ''does'' protect you from collision damage, only with it the bosses won't be running away while you drain two thirds of their lifebar with The Virus.
* If you've mastered fighting Wrath's ability to kick bombs, Dr. Fetus becomes this, giving you the ability to shoot ''infinite bombs.''
** Master nothing. Add Bobby-Bomb (homing bombs), and who needs aiming? Additional items like Ouija Board (bombs pass through walls), flight (so you can too), and Mr. Mega (HUGE bomb) makes the entire game a cakewalk. Even [[spoiler:Isaac]] goes down like nothing.
** If you know how to use it, then the base skill can become this. If you can avoid enemies and get them hit by the bombs, then you can kill every enemy in the game with basic bombs.
** That all pales in comparison to the Fetus+Bra combo. Activate the bra and fling bombs from the proper distance for the entire duration, and almost every boss in the game (even Mom) can be killed before it even gets an attack off. It'll even take half the life off of the Cathedral boss if you have four power or so, rather less the mega bomb and/or maximum power. And unlike a lot of boss combos, it's also ridiculously effective in the levels too, since the fetus all but guarantees that the stun time is enough to dispatch every enemy in the room without risk once every three rooms.
** It's not only useful in battles; you will essentially get a free secret room and super secret room each level if you take the time to look for them, which can have a massive impact depending on what they contain.
** Dr Fetus + Remote Detonator. Not only do you have an unlimited supply of bombs at your disposal, but the remote detonator gives you the ability to ''time'' your bombs' explosions; effectively negating the Dr. Fetus item's greatest downfall.
* The Nail. When used, it gives a spirit heart, increases damage, and lets player walk over rocks among with the other benefits. This was even more broken in earlier versions, where it gave ''two'' spirit hearts.
* Technology (piercing shots with unlimited range) + Chocolate Milk (charge shots) = Win [[http://www.youtube.com/watch?v=Si-4xJsPOxc (Northernlion approved).]]
* Steam Sale (everything in shops half off) + dollar (maximized cash) = shops being very useful.
* After the Halloween update, Brimstone. It replaces your previous attack with an extremely powerful and wide beam which can fire through obstacles but must be charged beforehand. Properly mastered, you'll be a killing machine. Get damage powerups and it becomes even more awesome.
* Whore of Babylon [[DifficultButAwesome (the item that puts you in a One Winged Angel state which maxes out your attack so long as, regular heart-wise, you're only a single hit away from death)]] is this when used by [[spoiler:Blue Baby]]. As he has no regular hearts (and can never get any), the effect is permanent.
* Mom's Knife + Mom's Contact. Mom's knife does rapid high-powered damage. Mom's contact has a chance of turning the target to stone per hit. Rapid hit + stone chance = stone enemy. Now, keep in mind Isaac can then just walk up to said immobile enemy with the knife, which will continue to do rapid damage plus turn them back to stone -- so only enemies with backup will survive once that first stone hit kicks in.
* Mom's Bottle of Pills + PHD. PHD removes all negative effect pills (damage, stat reduction), while the bottle lets you generate, at minimum, one pill every six rooms (with enemies). You may occasionally get neutral pills like Bombs Are Key, but (especially if you get it early) over time you're guaranteed to get a lot of tear/damage/range boosts, especially in the bigger levels. You can even use it with the Battery (plus [[SerialEscalation the 9-Volt]]) to speed up your stat-increasing even more! If you're playing as Cain, you don't even need the PHD, since his innate Lucky Foot pill has the same effect.
* The Prayer Card is the Game Breaker to end all Game Breakers. Once per six rooms, it allows you to create half of a Prayer/Eternal Heart. If you finish the stage with one of these, or manage to obtain a second one, you get a full heart container. To put it simply, if you're skilled, it lets you pull entirely new heart containers straight out of your ass, ''for free'', every twelve rooms. It gets even more hideously broken if you manage to get the Battery with it, giving you the opportunity to give you a new heart container ''every two rooms''. Naturally, this tends to make you able to completely buy out the Devil Room shops, making you an unstoppable force with insane power and health that doesn't even fit on the screen.
** TakenUpToEleven if you buy Guppy's Paw with those new heart containers. Guppy's Paw destroys one heart container in exchange for three soul/spirit hearts. Tough choice, right? Not if you already have 5 or 6 heart containers. Use up four or five of them, and that's an instant 12 or 15 spirit hearts!
* Technology 2 (which shoots a laser that is [[DeathOfAThousandCuts weak as all hell but hits constantly]]). Because it hits very quickly, it will almost always activate items with on-hit properties such as Mom's Contact (which gives your shots a chance to freeze enemies), The Mulligan (which gives you a chance to spawn a kamikaze attack fly whenever you shoot an enemy) or the Common Cold (Which gives shots a chance to poison).
** It's even more overpowered with Polythemus, which does ridiculous damage but sets tears to minimum. It's balanced, but with Technology 2 will down all bosses in seconds and one shot enemies.
* Speaking of Polyphemus, it synergises insanely with Brimstone. See DifficultButAwesome.
** Or with any weapon where the tears stat matters little (Dr Fetus, Ipecac, Tech2, Mom's Knife, etc)
* The Nun's Habit charge your item bar whenever you are hit. Doesn't seems so gamebreaking so far? [[http://youtu.be/1JSaG3zw38E?t=13m25s Well...]]
* The Crystal Ball is yet another item which breaks the game wide open when combined with the battery. Even on its own, however, it's rather overpowered: once every six rooms, you may reveal the map (if you have not done so already) AND receive either a spirit heart or an extra tarot card. This makes the final few levels of the game much quicker.
* Polythemus+Mom's Knife, [[http://www.youtube.com/watch?v=uKEhs2Di9Oc&feature=plcp Northernlion approved]] (for those who didn't watch the video, it allowed him to take down [[spoiler:[[DamageSpongeBoss Blue]] [[BulletHell Baby]]]] in a few seconds.
* The [=D6=] allows you to reroll powerups. Combine this with the battery for half charge per room and a room with green bomb spitters to blow the doors open, and you can reroll (tediously) until you get what you want.
* Scratch that, WotL brings in the [=D20=] from ''DungeonsAndDragons'' fame. It rerolls every single pick up in the room, so you can reroll marginally useful items like pennies and half hearts and get pills, soul hearts, faith hearts, tarot and poker cards, nickels, dimes, the whole spectrum of trinkets and chests with several pickups inside, possibly even a powerup. Chances of getting great stuff are low per pickup, but then you go to an Arcade and pile up a huge stack of half hearts, keys, etc from the machines to polymorph at once. Good thing it has a 6 room recharge...
* Epic Fetus, which launches guided missiles almost as fast as Dr. Fetus launches unguided bombs. If you get this, the only thing likely to kill you other than the final boss is hilarious incompetence. Perhaps in recognition of the fact, the unlock image has the fetus giving the finger while missiles fall all around it.
** Becomes even more powerful if you have A Pony. If you use the pony's charge attack, but not choose a direction, you will be completly invencible, so you can aim Epic Fetus's missiles with the mouse and clear any room with impunity.
* The Scapular gives you a soul heart one per room once you are on the last half heart (normal) or, on [[spoiler:???]], when you lose your last heart. Done right, you can use this to get lots of money from a heart donation machine by going to low health, exiting the room and going back after getting the extra soul heart, and use the machine twice, once in later levels, giving you another one. Exit, repeat. It also helps that it's basically regenerating health, allowing you more error. That ratio for error is small, but it's better than not being able to make error, but that part isn't really breaking.
* The Ankh. who revives you as [[spoiler:???/Blue Baby]] if you die. In terms of Steam Achievements and game content, you ARE [[spoiler:him]]. This nullifies half of the challenge of beating the game with [[spoiler:him]] if you get the Ankh on a lucky run with another character and die on purpose. It also makes it entirely possible to unlock the Forget Me Now and the Rainbow Baby before obtaining the D6.
* The X-Ray glasses. As noted above, they synergize with the battery for unlimited item charges. On their own, not only do they reveal secret room entrances, they also open them for you without needing bombs. Bombs are very important in the early game. They can also save you keys to enter a shop or item room if it happens to border a secret room.
